Processes for detecting toxic substances

ABSTRACT

Biology-based processes for detecting toxic substances are provided. The processes comprise detecting mRNA that is expressed in the presence of toxic substances by a cell comprising a yeast gene as followed, or a gene that is homologous to the yeast genes and is derived from other species, wherein the mRNA corresponds to said yeast gene or said homologous gene thereof.

This application is a Continuation of co-pending application Ser. No.11/722,057 filed Jun. 29, 2007, which is a divisional of applicationSer. No. 10/487,439 filed on May 27, 2004 and now abandoned, and ofwhich priority is claimed under 35 U.S.C. §120; and this applicationclaims priority of International Application No. PCT/JP2002/08494 filedon Aug. 23, 2002 and Application No. JP2001-255380 filed in Japan onAug. 24, 2001 under 35 U.S.C. §119. The entire contents of each of theseapplications is hereby incorporated by reference.

FILED OF THE INVENTION

This invention relates to biology-based processes for detecting toxicsubstances, and specifically to processes for detecting toxic substanceswhich comprises detecting mRNA that is transcribed in the presence oftest materials by a particular gene from yeast.

BACKGROUND ART

Environmental chemical fate search has been conducted every year for 24years from 1974 through 1998 by Environment Agency, and revealed thatabout 40% of 775 chemical substances that have been searched so far areemitted into the environment. Chemical substances that are industriallyproduced at the present in Japan are estimated about 50,000, and theproduction scale and the kinds of chemical substances are increasingyear by year. It is known that chemical substances that are accidentallyproduced by water treatment with chlorine and incineration pollute theenvironment. Although such facts allow us to predict that there are alarge number of chemical substances that have been accumulated in theenvironment, it is extremely difficult to search and examineindividually the all chemical substances.

Conventional bioassays (approaches to evaluate the harmful effects onbiological materials on the basis of their responses) wherein inhibitedgrowth and particular biological responses in individuals and cells offishes, daphnia and shellfish are used as indicators make it possible todetermine the presence or absence of the toxicity of chemical substancesin the environment, but neither possible to evaluate the characters nororigins of the toxicity. The evaluation methods based on the activity ofnitrite-forming bacteria or nitrate-forming bacteria (Japanese PatentPublication (kokai) No. 123705/1994, Japanese Patent Publication (kokai)No. 2000-206087) and the activity of iron bacteria have been proposed,and devices such as Acute toxicants monitor (Fuji Electric CorporateResearch and Development, Ltd. Japan) are marketed in Japan. In foreigncountries, the devices for evaluation based on emission intensity ofluminous bacteria are commercially available (MICROTOX, azur, Co., USA;LUMIS, drlange, Co. Germany). However, those devices still involveconventional bioassays, and never provide any detailed information oftoxic chemical substances.

In Japan, the risk control of chemical substances is reconsidered everytime a chemical substance pollution is newly found, and officialregulations and self-imposed regulations are combined to organize thesystem for risk control. However, any system has not been yet organizedthat could quickly respond to the present complicated and diversifiedconditions including accidental productions and environmental emissionof toxic chemical substance as typified by trihalomethane and dioxin.Animal experiments as used in the method for evaluation of toxicsubstance of “Law Concerning Examination and Manufacture, etc. ofChemical Substances” are expensive and time-consuming, and are notaccepted across the world. Although, as such, the control system hasbeen continuously discussed, it has not been successfully accomplishedbecause there is no way to dissolve the problem. Thus, a method fordetect readily chemical substances occurring in the environment isdesired.

DISCLOSURE OF THE INVENTION

The inventors of the present application found that a toxic substanceinduces the expression of mRNA from particular yeast genes, andaccomplished the present invention.

Specifically, the invention of the present application relates a processfor detecting a toxic substance, which comprises detecting mRNA that isexpressed in the presence of a test material by a cell comprising ayeast gene that is selected from a group consisting of the following, ora gene that is homologous to the yeast genes and is derived from otherspecies, wherein the mRNA corresponds to said yeast gene or saidhomologous gene thereof:

YBR072W, YCR102C, YCR107W, YDL218W, YDL243C, YDR453C, YDR533C, YFL014W,YFL056C, YFL057C, YGR110W, YJR155W, YKL071W, YKR076W, YLL060C, YLR460C,YMR090W, YNL331C, YNL332W, YNL335W, YOL150C, YOL165C, YPL171C, YPR167C,YBL048W, YBL064C, YBL107C, YBR008C, YBR173C, YBR256C, YBR296C, YDL021W,YFL022C, YFL024C, YFL061W, YGL121C, YGL158W, YGR043C, YHR029C, YHR112C,YHR139C, YHR179W, YHR209W, YIR030C, YJR010W, YJR048W, YKL001C, YKL107W,YKR075C, YKR097W, YLL056C, YLR297W, YLR303W, YML087C, YMR096W, YNL274C,YOL151W, YOR226C, YOR338W, YOR391C, YPL280W, YDR406W, YJL153C, YLR346C,YOR049C, YOR153W, YPL088W, YAL034C, YDL124W, YDL174C, YDR476C, YGL156W,YGR035C, YGR157W, YGR213C, YGR281W, YGR284C, YHL047C, YHR043C, YHR044C,YHR054C, YJR073C, YKL165C, YLR008C, YMR315W, YNL211C, YOL031C, YOL101C,YOR303W, YAL005C, YAR031W, YBL005W-A, YBL022C, YBL041W, YBL049W,YBL075C, YBL078C, YBR062C, YBR169C, YBR294W, YCL020W, YCL035C, YCL043C,YCL050C, YCL057W, YCR012W, YCR013C, YCR060W, YDL007W, YDL027C, YDL097C,YDL110C, YDL126C, YDL169C, YDR070C, YDR155C, YDR158W, YDR204W, YDR210W,YDR214W, YDR258C, YDR313C, YDR368W, YDR435C, YER012W, YER037W, YER091C,YER103W, YFL044C, YFR003C, YFR010W, YFR020W, YFR024C, YFR044C, YFR053C,YGL006W, YGL048C, YGL062W, YGL141W, YGL157W, YGL163C, YGL180W, YGL184C,YGR010W, YGR028W, YGR032W, YGR048W, YGR124W, YGR135W, YGR142W, YGR161C,YGR192C, YGR197C, YGR201C, YGR212W, YGR231C, YGR244C, YGR254W, YGR268C,YHL030W, YHR016C, YHR018C, YHR055C, YHR087W, YHR166C, YIL160C, YIR017C,YJL034W, YJL048C, YJL052W, YJL144W, YJL163C, YJR009C, YJR069C, YJR074W,YJR130C, YJR149W, YKL065C, YKL073W, YKL103C, YKL142W, YKL210W, YKL218C,YKR011C, YKR018C, YKR046C, YKR049C, YLL024C, YLL026W, YLR027C, YLR080W,YLR107W, YLR121C, YLR132C, YLR133W, YLR155C, YLR158C, YLR161W, YLR195C,YLR217W, YLR328W, YLR336C, YLR345W, YLR370C, YLR423C, YML004C, YML092C,YML128C, YML130C, YML131W, YMR040W, YMR118C, YMR214W, YMR251W, YMR297W,YMR322C, YNL036W, YNL055C, YNL071W, YNL094W, YNL134C, YNL155W, YNL160W,YNL239W, YNL241C, YOL005C, YOR020C, YOR027W, YOR037W, YOR059C, YOR120W,YOR134W, YOR152C, YOR173W, YOR289W, YOR362C, YPL240C, YPR030W, YAL008W,YAL023C, YAL060W, YAL062W, YAR009C, YBL101C, YBR006W, YBR046C, YBR052C,YBR053C, YBR056W, YBR099C, YBR137W, YBR139W, YBR149W, YBR170C, YBR177C,YBR203W, YBR207W, YBR212W, YBR239C, YBR284W, YBR293W, YCL018W, YCL033C,YCL040W, YCL049C, YCR062W, YCR067C, YCR082W, YDL010W, YDL020C, YDL024C,YDL054C, YDL095W, YDL100C, YDL115C, YDL144C, YDL198C, YDL223C, YDL245C,YDL246C, YDR001C, YDR032C, YDR058C, YDR072C, YDR127W, YDR168W, YDR169C,YDR188W, YDR231C, YDR261C, YDR264C, YDR272W, YDR293C, YDR304C, YDR330W,YDR403W, YDR411C, YDR427W, YDR436W, YDR497C, YDR511W, YDR516C, YDR519W,YDR545W, YEL012W, YEL030W, YER004W, YER009W, YER021W, YER035W, YER053C,YER079W, YER094C, YER096W, YER125W, YER158C, YER163C, YER175C, YER177W,YER178W, YER185W, YFL006W, YFL010C, YFL016C, YFL029C, YFL030W, YFL031W,YFL032W, YFL038C, YFL041W, YFR004W, YFR047C, YFR050C, YFR052W, YGL011C,YGL013C, YGL037C, YGL047W, YGL053W, YGL091C, YGL094C, YGL127C, YGL150C,YGL199C, YGL207W, YGL248W, YGR008C, YGR037C, YGR055W, YGR101W, YGR130C,YGR154C, YGR194C, YGR221C, YGR232W, YGR248W, YGR253C, YGR256W, YHL008C,YHR027C, YHR053C, YHR057C, YHR111W, YHR138C, YHR161C, YHR164C, YHR169W,YHR174W, YHR176W, YHR199C, YIL010W, YIL034C, YIL041W, YIL045W, YIL087C,YIL107C, YIL142W, YIL155C, YIR034C, YIR036C, YIR037W, YIR038C, YIR039C,YJL001W, YJL031C, YJL035C, YJL053W, YJL057C, YJL066C, YJL068C, YJL082W,YJL099W, YJL102W, YJL151C, YJL152W, YJL161W, YJL164C, YJL171C, YJL172W,YJL210W, YJL219W, YJR008W, YJR045C, YJR046W, YJR106W, YJR117W, YJR137C,YKL007W, YKL026C, YKL035W, YKL091C, YKL104C, YKL117W, YKL145W, YKL146W,YKL151C, YKL152C, YKL153W, YKL193C, YKL195W, YKL213C, YKL215C, YLL028W,YLL039C, YLL058W, YLR054C, YLR103C, YLR120C, YLR136C, YLR149C, YLR152C,YLR178C, YLR259C, YLR299W, YLR324W, YLR327C, YLR348C, YLR350W, YLR356W,YLR362W, YLR387C, YLR429W, YML054C, YML070W, YML100W, YML117W, YML125C,YMR004W, YMR008C, YMR009W, YMR020W, YMR067C, YMR089C, YMR097C, YMR102C,YMR105C, YMR107W, YMR152W, YMR180C, YMR184W, YMR191W, YMR219W, YMR271C,YMR275C, YMR295C, YMR314W, YMR316W, YNL006W, YNL007C, YNL012W, YNL044W,YNL045W, YNL074C, YNL092W, YNL093W, YNL104C, YNL115C, YNL156C, YNL231C,YNL234W, YNL237W, YNL281W, YNL305C, YNL333W, YNR010W, YNR019W, YNR033W,YNR059W, YNR068C, YNR069C, YOL032W, YOL036W, YOL047C, YOL071W, YOL082W,YOL083W, YOL117W, YOL119C, YOL126C, YOL131W, YOL153C, YOL162W, YOL163W,YOL164W, YOR019W, YOR035C, YOR036W, YOR099W, YOR117W, YOR124C, YOR130C,YOR132W, YOR157C, YOR185C, YOR197W, YOR259C, YOR261C, YOR273C, YOR288C,YOR332W, YOR336W, YOR347C, YPL017C, YPL087W, YPL106C, YPL109C, YPL149W,YPL154C, YPL196W, YPL206C, YPL222W, YPR023C, YPR024W, YPR026W, YPR067W,YPR103W, YPR108W, YPR151C, YAL012W, YBR029C, YBR222C, YCL009C, YCL027W,YCL064C, YCR098C, YDL222C, YDR055W, YDR077W, YDR502C, YEL001C, YEL042W,YER026C, YER106W, YGR136W, YGR138C, YHR137W, YHR142W, YIL023C, YIL153W,YJL073W, YJR004C, YJR054W, YKL039W, YKL086W, YKL163W, YKR091W, YLR109W,YLR194C, YLR250W, YMR095C, YMR189W, YNL106C, YNL169C, YNL322C, YOR181W,YOR198C, YOR208W, YOR247W, YPL089C, YAL038W, YAL053W, YBR023C, YBR214W,YBR295W, YCR048W, YDL072C, YDL204W, YDR085C, YDR098C, YDR259C, YDR380W,YDR388W, YDR391C, YDR432W, YDR481C, YDR510W, YER069W, YGL022W, YGL126W,YGL209W, YGL255W, YGR189C, YGR282C, YHL035C, YHR030C, YIL022W, YIL024C,YIL117C, YIL123W, YIL140W, YIL154C, YJL088W, YJL108C, YJL149W, YJL159W,YJL186W, YJR148W, YKL096W, YLR180W, YLR273C, YLR300W, YLR307W, YLR378C,YLR391W, YMR094W, YMR104C, YMR276W, YMR296C, YNL190W, YNL208W, YNL300W,YNR064C, YOL013C, YOL058W, YOR248W, YOR355W, YPL052W, YPL163C, YPR079W,YAR028W, YBR146W, YBR183W, YCL038C, YCR071C, YDL008W, YDR019C, YDR031W,YDR115W, YDR486C, YER038C, YER130C, YFL054C, YGL136C, YGR146C, YGR207C,YHL040C, YIL167W, YJL020C, YKR039W, YLR031W, YLR205C, YMR072W, YMR140W,YMR173W, YMR195W, YMR226C, YNL037C, YNR002C, YOL143C, YOR136W, YOR215C,YOR382W, YOR383C, YPL054W, YPL271W, YPR127W, YAL044C, YAL054C, YAR010C,YAR027W, YAR071W, YBL001C, YBL043W, YBL057C, YBR014C, YBR024W, YBR035C,YBR068C, YBR111C, YBR116C, YBR147W, YBR168W, YBR246W, YBR273C, YCR004C,YCR021C, YCR037C, YCR088W, YDL022W, YDL128W, YDL238C, YDR003W, YDR009W,YDR033W, YDR084C, YDR104C, YDR270W, YDR315C, YDR340W, YDR357C, YDR358W,YDR396W, YDR405W, YDR410C, YDR434W, YDR482C, YDR487C, YDR520C, YDR534C,YDR539W, YEL011W, YEL065W, YEL066W, YER039C, YER044C, YER067W, YER080W,YER107C, YFL020C, YFL028C, YFL043C, YFR015C, YGL001C, YGL008C, YGL068W,YGL073W, YGL104C, YGL113W, YGL154C, YGL167C, YGL229C, YGL242C, YGL249W,YGL253W, YGR052W, YGR060W, YGR065C, YGR106C, YGR111W, YGR220C, YGR257C,YHL023C, YHL048W, YHR004C, YHR037W, YHR071W, YHR092C, YHR190W, YIL007C,YIL033C, YIL070C, YIL088C, YIL111W, YIR002C, YIR016W, YIR035C, YIR043C,YJL012C, YJL083W, YJL089W, YJL116C, YJL131C, YJL132W, YJL196C, YJR061W,YJR086W, YJR142W, YJR161C, YKL008C, YKL013C, YKL041W, YKL067W, YKL138C,YKL139W, YKL150W, YKL175W, YKR006C, YKR014C, YKR070W, YLL023C, YLR023C,YLR093C, YLR118C, YLR142W, YLR225C, YLR241W, YLR251W, YLR252W, YLR270W,YML030W, YML110C, YMR021C, YMR027W, YMR148W, YMR181C, YMR262W, YMR272C,YMR298W, YNL011C, YNL130C, YNL214W, YNL259C, YOL129W, YOR042W, YOR052C,YOR137C, YOR149C, YOR165W, YOR270C, YOR285W, YOR367W, YPL018W, YPL156C,YPL186C, YPL203W, YPL216W, YPL255W, YPR006C, YPR073C, YPR098C, YBR050C,YBR145W, YBR299W, YDR518W, YEL020C, YFL062W, YGL039W, YGL134W, YJL217W,YJR159W, YLR126C, YNL249C, YNL284C, YNL336W, YOL157C, YOR344C, YOR381W,YPL265W, YPR124W, YBR074W, YBR109C, YBR126C, YBR201W, YCR005C, YDL248W,YDR041W, YDR105C, YDR268W, YDR452W, YEL075C, YER046W, YER050C, YER136W,YER159C, YGL250W, YGR019W, YGR042W, YGR053C, YGR066C, YGR247W, YGR255C,YGR295C, YHL044W, YHR145C, YIL058W, YIL065C, YIL083C, YIL098C, YIL172C,YJL030W, YJL185C, YJL213W, YJR029W, YJR099W, YJR122W, YJR125C, YKL190W,YKR020W, YLL025W, YLL051C, YLR043C, YLR090W, YLR100W, YLR108C, YLR290C,YML068W, YMR051C, YMR139W, YMR178W, YMR193W, YNL015W, YNL079C, YNL122C,YNL223W, YNL285W, YNL293W, YNR007C, YNR035C, YNR061C, YOL016C, YOL104C,YOR220W, YOR221C, YOR374W, YPL123C, YPR077C, YPR107C, YPR147C, YBR093C,YBR196C, YEL041W, YEL047C, YER023W, YER119C, YFL055W, YGR209C, YIL124W,YKL187C, YLL055W, YMR318C, YOL152W, YAL007C, YBR067C, YBR115C, YBR285W,YBR292C, YDL043C, YDL123W, YDL131W, YDL168W, YDL212W, YDR056C, YDR132C,YDR154C, YDR183W, YDR216W, YDR253C, YDR295C, YDR494W, YDR513W, YEL072W,YER045C, YER061C, YER181C, YFL052W, YFL058W, YFR030W, YGL089C, YGL096W,YGL114W, YGL193C, YGL202W, YGL204C, YGL259W, YGR006W, YGR070W, YGR088W,YHL034C, YHL036W, YHR048W, YHR104W, YHR163W, YIL060W, YIL136W, YIR024C,YJL036W, YJL045W, YJL060W, YJL101C, YJL155C, YJR085C, YJR109C, YJR156C,YKL070W, YKL161C, YKL221W, YKR071C, YLL009C, YLL050C, YLR092W, YLR145W,YLR156W, YLR163C, YLR220W, YLR280C, YLR311C, YLR390W, YML116W, YMR034C,YMR038C, YMR081C, YMR250W, YNL240C, YNL260C, YNL277W, YNR074C, YOL044W,YOL084W, YOL147C, YOL159C, YOR184W, YOR228C, YOR255W, YPL223C, YPR160W,YDL182W, YBR047W, YBR054W, YBR291C, YDR069C, YER124C, YER131W, YGR044C,YIL094C, YKR007W, YMR240C, YNR050C, YOR007C, YAL015C, YBL065W, YBR105C,YBR182C, YBR186W, YBR244W, YBR272C, YCL069W, YDL025C, YDL059C, YDL085W,YDL113C, YDL244W, YDR018C, YDR054C, YDR202C, YDR223W, YDR350C, YDR353W,YDR374C, YDR512C, YEL052W, YEL070W, YER098W, YFR017C, YGL046W, YGL067W,YGL098W, YGL117W, YGL146C, YGL240W, YGR011W, YGR067C, YGR133W, YGR153W,YGR223C, YHR116W, YHR124W, YIL097W, YIL168W, YJL103C, YJL221C, YJR036C,YJR095W, YKL085W, YKL133C, YKL162C, YKL188C, YKL217W, YKR061W, YKR105C,YLL062C, YLR174W, YLR216C, YLR247C, YLR260W, YLR267W, YLR389C, YML007W,YMR041C, YMR177W, YMR253C, YNL009W, YNL117W, YNL128W, YNL183C, YNR073C,YOL133W, YOL158C, YOR133W, YOR225W, YOR227W, YPL161C, YPL166W, YPL202C,YPL224C, YPR015C, YPR086W, YPR201W, YAL061W, YAL067C, YAR007C, YBL033C,YBL056W, YBL086C, YBR026C, YBR073W, YBR101C, YBR117C, YBR123C, YBR213W,YBR269C, YBR280C, YCR036W, YDL132W, YDL149W, YDL200C, YDL234C, YDL242W,YDR099W, YDR177W, YDR256C, YDR392W, YDR394W, YDR531W, YEL071W, YER014W,YER042W, YER090W, YER184C, YFL059W, YFR042W, YFR046C, YFR049W, YGL026C,YGL058W, YGL185C, YGL227W, YGL252C, YGL254W, YGR089W, YGR112W, YGR134W,YGR276C, YHL019C, YHR012W, YHR017W, YHR028C, YHR106W, YHR109W, YHR156C,YIL036W, YIL046W, YIL143C, YIL152W, YIL159W, YIL164C, YJL071W, YJL094C,YJL154C, YJR056C, YJR072C, YJR110W, YJR139C, YKL025C, YKL034W, YKL064W,YKL171W, YKL196C, YKR012C, YKR068C, YKR069W, YLL001W, YLL057C, YLL061W,YLR064W, YLR070C, YLR099C, YLR144C, YLR157C, YLR160C, YLR164W, YLR364W,YLR421C, YML032C, YML042W, YML112W, YML118W, YMR114C, YMR115W, YMR258C,YNL181W, YNL191W, YNL212W, YNL213C, YNL250W, YNL265C, YNL312W, YNR032W,YOL038W, YOL049W, YOL064C, YOR088W, YOR155C, YOR257W, YOR265W, YOR377W,YOR386W, YPL031C, YPL113C, YPL124W, YPL151C, YPL249C, YPL260W, YPL274W,YPR048W, YPR061C, YPR093C, YPR125W, YPR158W, YPR168W, YPR169W, YPR174C,YPR180W, YPR193C, YPR200C, YAL014C, YAL017W, YAL049C, YBL019W, YBL058W,YBR001C, YBR013C, YBR018C, YBR037C, YBR045C, YBR051W, YBR063C, YBR128C,YBR129C, YBR204C, YBR241C, YBR255W, YBR281C, YCL044C, YCL055W, YCR014C,YCR019W, YCR024C, YCR105W, YDL065C, YDL089W, YDL143W, YDL173W, YDL193W,YDL197C, YDL206W, YDL230W, YDL233W, YDR040C, YDR071C, YDR078C, YDR109C,YDR140W, YDR194C, YDR212W, YDR221W, YDR257C, YDR271C, YDR287W, YDR294C,YDR316W, YDR329C, YDR338C, YDR369C, YDR421W, YDR425W, YDR485C, YDR488C,YDR504C, YDR505C, YDR506C, YDR515W, YEL005C, YEL037C, YEL044W, YER017C,YER048C, YER052C, YER078C, YER089C, YER092W, YER100W, YER162C, YER182W,YFL021W, YFL042C, YFR045W, YFR051C, YFR056C, YGL040C, YGL041C, YGL045W,YGL057C, YGL093W, YGL105W, YGL125W, YGL166W, YGL181W, YGL183C, YGL215W,YGL216W, YGL221C, YGL223C, YGR007W, YGR029W, YGR155W, YGR156W, YGR186W,YGR198W, YGR210C, YGR211W, YGR237C, YGR250C, YGR258C, YGR266W, YGR270W,YGR274C, YGR277C, YHL021C, YHL037C, YHL038C, YHR082C, YHR083W, YHR134W,YHR160C, YHR171W, YHR180W, YHR205W, YIL062C, YIL072W, YIL075C, YIL099W,YIL108W, YIL165C, YIL170W, YIR009W, YIR018W, YIR031C, YIR032C, YJL032W,YJL049W, YJL128C, YJL165C, YJR044C, YJR052W, YJR090C, YJR091C, YJR103W,YJR104C, YJR153W, YKL059C, YKL079W, YKL090W, YKL094W, YKL192C, YKL209C,YKR052C, YKR102W, YKR106W, YLL054C, YLR025W, YLR097C, YLR200W, YLR226W,YLR248W, YLR266C, YLR392C, YLR427W, YML013W, YML029W, YML041C, YML051W,YML078W, YML079W, YML088W, YML099C, YMR056C, YMR068W, YMR091C, YMR110C,YMR160W, YMR186W, YMR255W, YNL005C, YNL026W, YNL039W, YNL063W, YNL064C,YNL077W, YNL083W, YNL147W, YNL176C, YNL194C, YNL253W, YNL257C, YNL261W,YNL264C, YNL276C, YNR006W, YNR034W, YNR047W, YNR051C, YNR071C, YOL065C,YOL067C, YOR005C, YOR008C, YOR022C, YOR023C, YOR058C, YOR069W, YOR087W,YOR138C, YOR229W, YOR256C, YOR267C, YPL005W, YPL020C, YPL022W, YPL105C,YPL147W, YPL150W, YPL152W, YPL164C, YPL168W, YPL180W, YPL188W, YPL194W,YPR025C, YPR047W, YPR049C, YPR066W, YPR081C, YPR134W, YPR140W, YPR148C,YPR155C, YPR172W, YPR185W, YAL018C, YAR064W, YBR012C, YBR076W, YBR287W,YDR043C, YDR250C, YDR373W, YFR014C, YGL191W, YGR180C, YHR136C, YJL026W,YJL037W, YLR038C, YNL058C, YOR031W, YGR087C, YIL166C, YHR008C, YIL129C,YGL256W, YJR030C, YMR077C, YBR264C, YPL177C, YKR040C, YGL056C, YDR128W,YGR139W, YBL101W-A, YOR253W, YOL026C, YDR278C, YHR095W, YCL042W,YNL200C, YPL221W, YLR415C, YMR058W, YPR037C, YER072W, YML028W, YOR325W,YAL039C, YMR112C, YJR107W, YGL088W, YJR058C, YNL142W, YDR090C, YMR071C,YBL093C, YGR293C, YML055W, YDL017W, YDL210W, YGL055W, YCL025C, YDR080W,YDL181W, YNR030W, YJL017W, YIL127C, YDR281C, YDR366C, YFR026C, YJL212C,YPL215W, YEL019C, YBR132C, YHL018W, YNL196C, YPL038W, YAR047C, YPL262W,YHL006C, YPL225W, YBR124W, YOR148C, YKR053C, YBL044W, YER029C, YLR360W,YCL056C, YCR007C, YGR239C, YNL256W, YPR146C, YLR377C, YKL097C, YBR066C,YLR338W, YDL229W, YBR253W, YJR027W, YKL198C, YBL030C, YBR031W, YBR118W,YBR162C, YBR221C, YCR024C-A, YCR106W, YDL046W, YDR012W, YDR133C,YDR134C, YDR276C, YDR342C, YDR343C, YEL027W, YEL034W, YGR038W, YGR243W,YGR279C, YHR094C, YHR105W, YHR175W, YHR181W, YIL056W, YIL162W, YJL059W,YJL097W, YJL158C, YJR105W, YKL051W, YKL056C, YKL097W-A, YKL100C,YKL141W, YKR066C, YLR134W, YLR258W, YLR339C, YML058W, YMR083W, YMR203W,YNL209W, YNL307C, YOL030W, YOR178C, YPL028W, YPR028W, YPR113W, YPR149W,YPR150W, YPR183W, YAL016W, YBL099W, YBL100C, YBR011C, YBR096W, YBR100W,YBR127C, YBR283C, YBR286W, YCL008C, YCL058C, YCR030C, YCR034W, YCR069W,YDL015C, YDL023C, YDL061C, YDL086W, YDR038C, YDR039C, YDR050C, YDR151C,YDR178W, YDR233C, YDR284C, YDR298C, YDR345C, YDR359C, YDR382W, YDR385W,YDR400W, YDR407C, YDR538W, YEL024W, YEL033W, YEL063C, YER057C, YER081W,YER120W, YFL011W, YGL012W, YGL206C, YGR022C, YGR026W, YGR082W, YGR107W,YGR172C, YGR191W, YGR204W, YGR260W, YHL005C, YHL046C, YHR025W, YHR026W,YHR123W, YHR126C, YHR143W, YIL011W, YIL015W, YIL018W, YIL157C, YIR041W,YJL016W, YJL121C, YJL133W, YJL138C, YJL191W, YJR018W, YJR047C, YJR077C,YJR119C, YJR121W, YJR123W, YJR143C, YJR145C, YKL060C, YKL147C, YKL148C,YKL157W, YKL164C, YKL169C, YKR033C, YLL041C, YLL064C, YLR041W, YLR044C,YLR056W, YLR058C, YLR081W, YLR089C, YLR110C, YLR177W, YLR264W, YLR284C,YLR304C, YLR340W, YLR354C, YLR372W, YLR388W, YML022W, YMR007W, YMR011W,YMR015C, YMR092C, YMR101C, YMR156C, YMR205C, YMR215W, YMR261C, YMR323W,YNL069C, YNL135C, YNL195C, YNR076W, YOL039W, YOL073C, YOL086C, YOL120C,YOL156W, YOL161C, YOR002W, YOR009W, YOR010C, YOR085W, YOR108W, YOR128C,YOR129C, YOR142W, YOR161C, YOR176W, YOR230W, YOR298W, YPL004C, YPL036W,YPL048W, YPL057C, YPL059W, YPL061W, YPL135W, YPL179W, YPL218W, YPL220W,YPL246C, YPL272C, YPR063C, YPR080W, YPR181C, YBR290W, YCR010C, YCR091W,YDL107W, YDL129W, YDR066C, YDR529C, YFL026W, YGL018C, YGL059W, YNL144C,YOR003W, YAL037W, YAR023C, YBR003W, YBR020W, YBR044C, YBR091C, YBR185C,YBR282W, YCR015C, YCR038C, YCR043C, YDL119C, YDL146W, YDL220C, YDR057W,YDR123C, YDR125C, YDR222W, YDR225W, YDR277C, YDR286C, YDR347W, YDR408C,YDR438W, YDR479C, YDR483W, YEL039C, YEL057C, YEL073C, YER066W, YER076C,YER084W, YER121W, YER189W, YFL017C, YFL046W, YFR006W, YFR008W, YGL115W,YGL208W, YGL214W, YGL218W, YGR021W, YGR023W, YGR024C, YGR064W, YGR076C,YGR096W, YGR108W, YGR174C, YGR182C, YGR236C, YGR288W, YHL042W, YHR195W,YHR210C, YIL006W, YIL012W, YIL028W, YIL050W, YIL057C, YIL089W, YIL102C,YIL113W, YIL122W, YJL100W, YJL169W, YJL199C, YJR039W, YJR050W, YJR101W,YKL003C, YKL016C, YKL061W, YKL093W, YKL121W, YKL160W, YKL170W, YKL194C,YKR034W, YKR067W, YLR006C, YLR016C, YLR030W, YLR036C, YLR112W, YLR125W,YLR128W, YLR204W, YLR211C, YLR233C, YLR257W, YLR288C, YLR326W, YLR334C,YLR395C, YLR408C, YLR414C, YLR444C, YML050W, YML107C, YML120C, YMR031C,YMR053C, YMR073C, YMR162C, YMR204C, YMR206W, YMR284W, YNL010W, YNL025C,YNL127W, YNL139C, YNL217W, YOL116W, YOL118C, YOR053W, YOR100C, YOR103C,YOR122C, YOR150W, YOR187W, YOR251C, YOR312C, YOR327C, YOR348C, YOR352W,YOR388C, YOR394W, YPL001W, YPL033C, YPL066W, YPL148C, YPL230W, YPL275W,YPL276W, YPR005C, YPR014C, YPR192W, YPR194C, YBR005W, YER025W, YFL027C,YGL080W, YGL205W, YHL028W, YHR185C, YIL076W, YJL166W, YLR046C, YMR035W,YMR238W, YMR252C, YNL192W, YNL202W, YOL108C, YOR385W, YPR165W, YAR033W,YBL038W, YBR009C, YBR010W, YBR151W, YCL067C, YCR096C, YDL137W, YDL192W,YDR073W, YDR086C, YDR224C, YDR377W, YDR378C, YER015W, YGL187C, YHR162W,YJL167W, YJL216C, YKR009C, YLR165C, YMR197C, YNL157W, YOL002C, YOL109W,YOR180C, YPL010W, YPL233W, YBR036C, YDR297W, YGR149W, YGR224W, YNL043C,YPL067C, YPL170W, YCR046C, YDR387C, YFL050C, YGL051W, YHR132C, YIL112W,YJL141C, YKR098C, YLR052W, YLR206W, YML129C, YNL203C, YNR014W, YOL043C,YOL096C, YPR184W, YAL028W, YAL055W, YAR062W, YBL095W, YBL102W, YBR122C,YBR157C, YBR161W, YBR251W, YBR298C, YCR039C, YCR083W, YDL018C, YDL067C,YDL078C, YDL091C, YDL215C, YDL216C, YDR022C, YDR067C, YDR079W, YDR181C,YDR186C, YDR196C, YDR262W, YDR306C, YDR319C, YER188W, YGL004C, YGL035C,YGR036C, YGR062C, YGR120C, YGR131W, YGR141W, YGR167W, YGR287C, YHL024W,YHR080C, YHR097C, YIL077C, YJL046W, YJL070C, YJL096W, YJL113W, YJL146W,YJL180C, YJR019C, YJR049C, YKR058W, YLL005C, YLR078C, YLR151C, YLR271W,YLR295C, YLR351C, YLR375W, YMR023C, YMR025W, YMR135C, YMR210W, YMR267W,YMR278W, YMR293C, YNL073W, YNR037C, YNR040W, YNR072W, YOR028C, YOR316C,YOR328W, YOR363C, YPL039W, YPL040C, YPL099C, YPL107W, YPL134C, YPL138C,and YPL140C.

The base sequences of those yeast genes and the amino acid sequences ofthe corresponding protein are disclosed in public databases such as MIPSin Germany: Munich Information Center for Protein Sequence, and SGD inUSA: Saccharomyces Genome Database, and are known via the internet.

In addition to the yeast genes as described above, genes that arehomologous to the yeast genes and are derived from other species may beused in the invention. In this context, “a gene(s) that is (are)homologous to the yeast genes” means genes that comprise a base sequencehaving a homology of 50% or more, preferably 80% or more to the basesequences of yeast genes, and that encode a protein having the samefunctions as the proteins encoded by the yeast genes.

Cells as used herein may be either eukaryotic or prokaryotic cells aslong as they comprise the genes as described above. Preferred cells areyeast cells.

Methods for detecting mRNA have been previously known, and any one ofthose methods may be used in the present invention.

As an embodiment of the invention, mRNA is detected through reversetranscription-PCR. Reverse transcription-PCR is well known in the art.See, for example, NAKABEPPU Yusaku, et al.: Cell Technology, suppl. Tipsseries, Modified PCR Tips, Shujunsha Co. Ltd., 1999, pp 25-43. Forexample, the invention comprises:

-   (1) adding a test material to the cell, and incubating the mixture;-   (2) extracting mRNA from the cell;-   (3) preparing cDNA from the mRNA via reverse transcription using    labeled nucleotides; and-   (4) hybridizing the cDNA as used as probe with the gene as described    above.

Incubation of cells may be conducted using usual media and usualtemperatures. Test materials comprising a chemical substance to betested are added to the medium, and the cells are incubated further forseveral hours. Concentrations of the test materials are selected to notlead to cell death. Test materials may comprise one or more chemicalsubstances.

For methods of extraction of mRNA, it is well known that apolynucleotide having a poly T structure which is immobilized on thesurface of magnetic beads or latex beads is used to trap the mRNA, andthen the mRNA is washed and eluted with spine column in view of the factthat a poly A chain is attached to the 3′ terminus of mRNA, which isreadily conducted using a commercially available kit such asOligotex-dT30<Super>mRNA Purification Kit, Takara. The mRNA isreverse-transcribed with a reverse transcriptase (Super Script IIReverse Transcriptase; catalogue No. 18064-014, GibcoBRL) usingfluorescence-labeled nucleotides. As such, labeled cDNAs that areintroduced with fluorescence-labeled nucleotides during the reversetranscription are obtained. Reverse transcriptases and nucleotides thatare labeled with Cy3-dUTP or Cy5-dUTP are also commercially available(for example, Super Script II Reverse Transcriptase; catalogue No.18064-014, GibcoBRL). Fluorescence-labeled cDNAs are detected with afluorophotometer.

RT-PCR is a procedure for detection and quantitative determination of anintended RNA in a form of the amplified cDNA, which comprisesreverse-transcribing mRNA into cDNA with a reverse transcriptase, andconducting PCR using the cDNA as a starting material as well as specificprimer sets and a thermostable DNA polymerase.

In the present step, a microarray containing the gene as described above(DNA tip) may be prepared to hybridize them with the cDNAs, therebyfacilitating the efficient detections, which is a preferred embodimentof the present invention.

As another embodiment of the invention, the mRNA is detected by northernblotting. Northern blotting is well-known in the art (OGATA Nobukuni,NOJIMA Hiroshi: Genetic Engineering Keywords Book, revised 2nd ed.,Yodosha, co.jp, 2000, pp 299-301). For example, the process comprises

-   (1) adding a test material to the cell, and incubating the mixture;-   (2) extracting mRNA from the cell; and-   (3) hybridizing the mRNA with the gene as described above.

Procedures of northern blotting comprises electrophoresing the RNA,transferring the pattern to a filter, and hybridizing it with a specificprobe labeled with an isotope, thereby analyzing the presences and theamount of the mRNA in a sample as well as the length of the same.

In the present step, a microarray containing the gene as described above(DNA tip) may be prepared to hybridize them with the cDNAs, therebyfacilitating the efficient detections.

In further another embodiment of the present invention, the detection ofmRNA is conducted by detecting the production of a polypeptide encodedby the yeast gene as described above. The production of a polypeptidemay be detected for example using an antibody directed to thepolypeptide.

Toxic substances to be detected according to the present inventioninclude arsenic, cadmium, mercury, 4-nitroquinolin-N-oxide,2,4,5-trichlorophenol, γ-hexachlorocyclohexane, manganeseethylenebis(dithiocarbamate),2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile, tetramethylthiuramdisulfide, Zinc N,N′-ethylenebis(dithiocarbamate), gingerol, acrolein,and dimethylsulfoxide, all of which are mutagenic.

The following examples are presented for purpose of further illustrationof the invention, and such examples are not intended to be limiting theinvention in any respect.

EXAMPLES Example 1

Yeast (Saccharomyces cerevisiae S288C (α SUC2mal mel gap2 CUP1)) wereincubated at 25° C. on YPD medium (yeast extract 1%, polypepton 2%,glucose 2%). One of toxic chemical substances was added to the cells atlogarithmic growth phase, and the cells were further incubated for twohours. Cells were cultured without any chemical substance in the samecondition, and were used as control. Concentrations of the chemicalsubstances were defined to inhibit the growth of the yeast but not leadto death.

Chemical Substances Concentrations (1) Na₂As 0.3 mM (2) CdCl₂ 0.3 mM (3)HgCl₂ 0.7 mM (4) PbCl₂ 2 mM (5) 4-nitroquinolin-N-oxide 0.2 μM (6)2,4,5-trichlorophenol 16 μM (7) γ-hexachlorocyclohexane 1.3 mM (8)manganese ethylenebis(dithiocarbamate) 2 ppm (9)2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile 10 μM (10)Tetramethylthiuram disulfide 75 μM (11) zincN,N′-ethylenebis(dithiocarbamate) 2 ppm (12)8-methyl-N-vanillyl-6-nonenamide 0.82 mM (13) gingerol 1.36 mM (14)acrolein 0.20 mM (15) dimethylsulfoxide 1.41 M (16) Roundup (trademark,herbicide)¹⁾ 1500-fold dilution (17) sodium dodecylbenzosulfonate 0.02%(18) sodium lauryl sulfate 0.01% ¹⁾N-(phosphomethyl) glycinate ammonium41.0%, surfactant 59.0%

After completion of the incubation, the culture was centrifuged tocollect the cells. To the cells, sodium acetate buffer (50 mM sodiumacetate, 10 mM EDTA, 1% SDS) was added, and the mixture was shaken at65° C. for five minutes, followed by returning to room temperature, andobtaining the supernatant, of which the procedures were repeated twotimes. To the supernatant, ½ amount of a solution of phenol/chloroformwas added, and the mixture was centrifuged to give a supernatant, whichwas added with an equal amount of chloroform, and the mixture wascentrifuged to give a supernatant. To the supernatant, an equal amountof isopropanol containing 0.3 M sodium acetate was added, and themixture was allowed to stand at room temperature for 30 minutes, afterwhich the mixture was centrifuged to give a sediment of the whole RNAs.Seventy % ethanol was added to the sediment, and the mixture was againcentrifuged to give a sediment, which was then dried and dissolved inwater. mRNA was isolated from the whole RNAs as followings. In view ofthe fact that a poly A chain is attached to the 3′ terminus of mRNA, apolynucleotide having a poly T structure which was immobilized on thesurface of latex beads was used to trap the mRNA, and then the mRNA waswashed and eluted with spine column (Oligotex-dT30<Super>mRNAPurification Kit, Takara). Reverse transcription of the mRNA wasconducted with a reverse transcriptase (Super Script II ReverseTranscriptase; catalogue No. 18064-014, GibcoBRL) usingfluorescence-labeled nucleotides to give cDNAs that were introduced withCy3-dUTP or Cy5-dUTP during the reverse transcription.

The labeled cDNAs were dissolved in TE buffer (10mM Tris-HCl/1 mM EDTA,pH8.0), and the solution was dropped on the DNA chip containing thewhole genes of yeast (DNA Chip Research Inc. Japan) so that the cDNAswere hybridized on the DNA chip at 65° C. for over 12 hours. Thefluoresces intensity of the DNA chip was read with a scanner, and theratio relative to the fluorescence intensity resulting from the absenceof chemical substance was estimated as the following, which is shown inTables 1 to 9:

$\frac{{The}{\mspace{11mu}\;}{level}\mspace{14mu}{of}\mspace{14mu}{expressed}\mspace{14mu}{mRNA}\mspace{14mu}{in}\mspace{14mu}{the}\mspace{14mu}{presence}\mspace{14mu}{of}\mspace{14mu}{chemical}\mspace{14mu}{substance}}{{The}{\mspace{11mu}\;}{level}\mspace{14mu}{of}\mspace{14mu}{expressed}\mspace{14mu}{mRNA}\mspace{14mu}{in}\mspace{14mu}{the}\mspace{14mu}{presence}\mspace{14mu}{of}\mspace{14mu}{chemical}\mspace{14mu}{substance}}$

TABLE 1 Unknown protein yeast genes The level of expressed mRNA in thepresence of chemical substance/The level of expressed mRNA in theabsence of chemical substance Inten- yeast genes (1) (2) (3) (4) (5) (6)(7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) sity YCR102C3.4 3.2 2.4 1.1 0.7 0.4 1.1 4.9 9.8 61.5 13.5 0.5 1.1 4.1 0.9 1.2 1.11.2 0.53 YDL218W 3.5 1.2 2.6 1.4 0.7 0.9 1.1 1.5 72.5 12.6 5.7 0.9 1.14.8 1.1 3.5 1.1 0.9 0.42 YDR533C 3.4 4.9 3.5 1.8 1.3 2.2 1.7 5.4 7.312.7 7.7 1.4 3.0 2.9 2.5 6.7 2.3 2.7 1.82 YGR110W 1.6 3.1 2.2 5.9 0.90.9 1.7 1.5 6.4 4.8 0.5 1.4 3.6 2.8 1.2 17.1 0.9 2.1 0.19 YKL071W 8.33.8 5.4 2.8 1.1 18.6 3.7 24.7 162.2 109.2 40.3 1.0 8.4 21.9 1.7 2.2 1.00.9 0.31 YLR460C 2.1 2.1 2.0 1.1 1.3 0.6 1.1 8.1 13.9 31.6 14.3 0.4 0.73.5 0.7 1.8 1.0 1.1 0.48 YMR090W 6.9 9.5 2.3 3.5 0.7 3.8 2.7 3.9 16.76.1 8.8 2.2 6.9 6.5 1.9 5.1 1.8 2.8 1.30 YOL150C 4.1 3.7 9.9 0.9 1.0 5.22.4 3.7 10.8 8.3 9.4 2.9 8.9 5.7 1.8 3.1 2.7 2.2 0.47 YBL048W 2.0 7.92.3 2.8 1.3 2.0 1.9 1.2 7.2 4.4 2.0 1.2 2.7 2.0 4.1 5.7 1.3 1.0 0.29YBL107C 1.4 1.1 0.4 1.5 1.2 1.1 2.1 1.9 1.0 3.1 2.9 1.4 2.6 2.5 1.4 1.50.9 1.4 1.03 YFL024C 1.0 1.1 1.1 0.7 1.1 2.0 3.3 0.9 0.5 0.5 0.6 0.8 0.93.3 0.9 1.1 0.9 0.8 0.37 YGL121C 2.6 5.0 1.4 4.2 0.9 9.8 4.7 3.0 7.015.0 6.1 1.6 7.8 5.8 1.6 8.5 2.7 3.5 0.60 YHR029C 2.8 1.8 1.8 1.8 1.02.7 2.0 2.7 13.6 8.6 3.8 1.5 4.7 3.5 1.0 1.0 2.1 2.1 0.87 YHR209W 2.81.1 0.8 4.5 1.8 3.2 5.0 2.0 2.9 6.4 3.3 1.0 2.0 2.2 5.0 3.5 2.6 2.6 0.56YKL107W 2.4 2.5 0.5 0.8 1.1 2.0 1.1 0.9 28.2 8.3 2.0 1.0 1.9 3.4 1.7 3.51.6 0.9 0.17 YKR075C 1.5 0.7 2.7 4.5 1.2 1.5 1.4 2.0 0.2 0.6 1.3 2.3 3.82.7 0.4 4.3 2.4 1.9 1.15 YLL056C 2.1 2.3 3.0 2.0 1.1 0.6 1.0 1.3 58.88.8 1.7 1.3 6.8 11.0 1.5 4.8 5.3 2.5 0.32 YLR297W 2.4 2.1 3.5 1.7 1.30.8 1.1 1.3 2.1 5.5 3.5 0.8 0.8 2.3 0.7 1.8 0.7 1.0 0.81 YOR338W 1.8 1.80.5 1.7 1.6 2.6 1.3 2.2 0.6 3.5 0.8 1.2 1.4 2.5 1.8 1.0 1.1 0.5 0.52YOR391C 2.1 2.0 0.9 1.2 1.3 1.6 2.0 2.8 18.8 18.1 3.2 1.1 2.3 2.4 5.82.2 1.0 0.9 0.22 YPL280W 1.7 1.9 1.9 2.0 1.4 1.9 1.8 2.3 49.8 14.0 1.90.9 2.4 2.4 4.3 1.5 1.2 0.9 0.22 YLR346C 4.4 2.0 2.1 4.5 1.4 5.5 5.6 1.38.6 6.6 0.5 4.2 6.2 2.2 1.0 2.4 10.6 7.8 0.53 YOR049C 2.5 0.9 12.8 1.41.3 8.4 4.2 0.9 1.1 1.9 1.1 6.7 7.1 1.5 1.3 4.3 2.6 2.9 0.22 YAL034C 1.11.8 2.8 1.1 1.0 1.5 1.8 1.0 3.0 3.3 1.5 2.8 4.9 1.2 1.4 1.0 1.2 1.3 0.52YDR476C 0.7 1.8 6.0 1.2 0.5 3.1 1.5 1.3 1.7 3.4 1.6 2.1 2.8 1.1 2.2 2.02.4 1.5 0.58 YGR035C 1.6 0.6 1.2 0.6 1.3 3.3 1.1 0.9 1.1 0.5 0.4 3.3 2.10.8 0.3 1.9 2.5 4.3 1.04 YGR284C 1.0 2.0 4.0 1.4 1.2 1.4 2.2 1.1 4.3 1.81.7 2.1 3.6 1.2 3.9 1.9 1.3 2.1 2.57 YHR054C 1.7 0.9 2.2 1.0 1.0 2.9 1.61.8 2.6 7.7 0.9 3.6 5.8 1.0 0.8 2.2 5.1 3.4 0.80 YLR008C 0.9 0.5 0.7 0.91.3 2.7 2.0 1.0 0.4 0.7 0.8 3.5 6.2 1.6 0.7 1.7 5.4 4.9 2.00 YMR315W 4.31.8 1.7 4.2 2.9 2.0 2.4 2.6 3.2 2.0 2.5 1.3 2.5 1.6 2.1 2.8 1.76 YNL211C1.2 1.0 0.8 1.0 1.0 7.4 3.1 1.1 0.8 1.1 1.1 3.2 9.9 1.1 0.8 9.3 4.2 6.80.52 YOL031C 0.9 1.9 1.0 1.7 1.2 1.0 2.5 2.1 2.3 1.4 1.3 2.1 2.4 1.1 4.41.5 1.2 1.9 1.20 YOL101C 0.9 0.8 0.4 1.7 1.6 0.5 0.7 0.9 0.1 0.3 0.9 2.40.2 0.8 0.6 3.5 0.6 0.6 1.37 YAR031W 1.5 1.1 1.1 1.7 1.1 2.9 1.6 1.2 2.71.6 1.4 1.2 3.3 1.4 0.9 3.5 1.6 2.5 1.00 YBL049W 2.9 11.8 2.1 2.9 1.11.7 1.9 5.2 5.2 2.2 0.7 3.9 1.5 7.2 6.4 1.1 1.1 0.47 YBR062C 1.3 1.7 0.41.2 1.4 1.9 1.5 1.9 5.4 2.2 2.3 1.2 2.8 2.6 0.7 2.2 1.4 1.6 0.93 YCR013C1.3 1.4 5.0 1.1 1.1 1.8 1.6 0.7 0.8 1.3 2.4 1.4 3.9 1.5 1.6 1.6 1.1 1.32.80 YDL027C 1.2 2.0 1.7 1.7 1.2 2.1 2.9 1.5 2.0 2.3 1.7 1.7 3.2 1.1 1.41.8 1.4 2.0 0.69 YDL110C 1.5 1.4 1.1 2.1 0.8 1.7 2.5 1.8 3.0 2.3 1.9 1.52.7 2.7 1.3 3.6 2.0 4.4 1.27 YDL169C 1.7 1.7 1.1 1.3 1.1 2.6 2.1 1.3 7.34.7 1.2 1.2 3.7 2.7 2.2 3.8 1.5 1.6 0.42 YDR070C 2.2 6.4 3.6 3.5 0.9 6.21.4 1.9 13.9 6.0 4.1 4.3 6.6 2.0 2.1 15.1 1.2 3.1 0.44 YDR210W 1.1 1.00.9 1.0 2.0 1.2 1.5 1.4 0.5 1.0 1.0 1.0 2.3 1.1 1.0 1.5 1.9 1.9 1.82YDR214W 1.3 4.0 4.5 1.3 1.1 1.7 1.5 1.5 5.5 2.4 1.9 1.1 5.3 1.2 1.1 0.71.2 1.0 1.07 YDR435C 1.2 1.1 1.2 1.4 1.2 2.5 2.1 1.2 0.8 2.1 1.3 1.1 2.51.3 0.6 2.0 1.3 2.0 1.30 YER037W 2.0 2.1 0.8 1.1 1.3 3.2 2.6 1.0 1.0 5.51.5 1.2 3.0 1.7 0.8 1.8 1.7 2.6 1.17 YFL044C 1.0 1.5 0.8 2.3 1.6 1.3 1.61.4 5.2 3.7 2.2 1.2 4.7 1.2 1.0 1.8 1.3 1.4 0.50 YFR003C 1.2 1.5 0.8 1.61.0 2.2 1.4 1.4 8.3 3.1 1.4 0.9 2.5 2.1 1.0 1.4 1.3 1.8 1.01 YFR020W 1.00.9 1.2 1.0 0.9 1.4 1.1 0.9 3.7 3.5 1.4 0.9 2.3 1.8 2.6 1.0 1.2 0.9 0.61YFR044C 0.9 1.3 3.8 1.1 0.9 2.1 1.2 0.8 2.1 2.2 1.9 1.2 3.1 0.8 1.5 1.21.0 1.0 1.99 YGR010W 1.2 1.6 0.9 1.2 0.8 1.2 1.7 1.6 13.6 8.9 1.5 0.95.2 1.9 1.3 1.4 0.8 1.3 0.55 YGR142W 2.7 6.2 15.3 1.3 1.3 0.9 1.4 1.536.8 12.2 2.3 2.0 8.9 0.9 1.3 0.3 1.9 1.5 1.28 YGR161C 2.0 2.2 5.4 3.81.0 1.4 1.4 1.3 2.0 3.8 0.8 1.7 2.8 0.9 1.7 1.1 1.5 1.8 0.65 YGR212W 1.51.7 1.5 1.3 1.2 1.0 1.1 3.8 0.9 1.5 10.0 1.1 1.1 2.1 3.9 2.2 0.28YGR268C 1.1 2.3 2.0 2.5 1.1 1.1 1.0 1.1 4.1 1.6 0.8 1.0 2.8 1.0 1.5 1.21.5 1.4 0.48 YHR016C 0.8 1.5 1.7 1.5 1.8 3.7 0.8 2.8 2.0 2.2 1.3 3.3 0.90.6 2.1 1.2 1.4 0.51 YHR087W 1.2 2.7 8.6 2.8 0.7 4.2 3.4 1.2 4.1 3.9 3.71.4 4.0 1.5 1.9 3.8 1.2 2.9 1.34 YJL048C 1.7 2.5 2.0 2.9 0.9 1.5 0.7 1.51.2 3.8 3.2 1.1 2.4 1.7 0.6 2.3 1.6 2.5 0.82 YJL144W 1.9 1.6 2.2 1.6 1.21.7 1.7 1.3 14.6 8.9 3.0 0.8 3.9 1.6 1.0 2.5 2.2 2.4 0.60 YJL163C 1.21.9 1.7 1.5 0.9 2.8 2.3 0.7 14.5 2.5 3.1 2.0 4.5 1.0 2.0 2.8 1.5 1.70.28 YJR074W 1.0 1.4 2.0 2.0 0.7 1.2 1.8 1.3 3.7 3.1 1.2 2.0 2.8 1.7 3.41.5 1.8 1.9 0.68 YKL065C 1.9 2.0 1.3 1.7 1.0 2.3 3.8 1.8 3.1 3.9 1.3 1.33.0 2.1 1.7 2.8 2.8 4.6 2.29 YKR011C 1.1 1.6 0.9 1.6 1.2 2.3 2.7 2.0 4.74.4 1.5 1.1 3.5 1.4 1.8 1.3 1.3 1.9 0.66 YKR018C 0.7 1.1 1.7 0.7 0.9 1.71.0 0.7 3.9 1.7 1.4 1.0 3.0 1.1 1.0 1.8 1.0 1.2 0.98 YKR046C 1.9 7.8 2.81.8 0.6 1.9 1.3 0.8 3.9 2.0 2.6 1.3 2.8 1.9 2.9 3.5 1.2 1.9 0.73 YKR049C1.6 4.2 1.0 3.2 0.9 3.0 2.4 1.3 2.2 3.2 2.2 1.2 4.1 2.1 0.9 4.2 1.6 3.31.17 YLR132C 1.0 1.1 0.3 1.1 1.2 1.1 1.1 0.7 4.5 2.5 0.5 1.0 2.7 1.3 2.31.6 1.2 1.6 0.36 YLR161W 0.9 0.8 0.8 0.7 0.9 1.2 1.3 0.8 1.0 1.5 1.5 0.82.1 1.0 0.6 1.1 1.1 0.9 0.33 YLR217W 0.9 2.0 2.1 0.7 1.4 1.4 1.5 1.0 3.28.2 0.9 3.8 0.9 0.9 0.8 1.0 1.2 0.35 YLR328W 1.3 1.2 1.3 0.9 0.9 4.8 5.41.1 0.9 1.2 1.4 1.2 4.3 0.5 0.8 1.4 1.1 0.8 1.04 YML128C 1.5 3.3 4.1 4.10.5 5.1 2.8 1.1 5.1 3.1 2.9 1.4 4.9 1.4 2.6 5.6 2.0 5.5 1.66 YMR040W 3.12.9 0.9 2.8 1.7 2.8 5.1 1.7 1.4 1.4 1.5 2.1 5.2 1.8 2.0 2.7 3.1 3.7 0.62YMR251W 1.3 1.3 1.8 0.6 2.2 1.6 3.1 1.7 3.1 11.6 2.8 1.2 2.5 1.5 0.4 1.31.5 0.9 0.20 YMR322C 2.0 4.3 1.5 2.9 1.4 1.8 1.7 2.1 21.3 10.3 3.2 1.12.1 2.7 3.6 1.8 1.4 0.8 0.18 YNL094W 0.9 1.4 1.1 1.0 1.4 2.9 1.2 2.0 3.52.6 1.7 1.2 3.4 1.0 1.5 1.5 1.1 1.3 0.66 YNL134C 2.3 6.0 4.5 0.9 1.7 1.41.5 3.2 6.1 5.9 5.0 1.1 3.1 1.4 0.8 2.1 1.3 2.0 2.51 YNL155W 1.1 1.2 1.10.9 1.4 3.0 1.3 1.7 5.8 2.7 2.2 1.1 4.4 2.1 2.0 2.0 1.1 1.6 1.89 YOR059C1.2 1.2 0.4 0.9 1.4 1.1 2.2 1.3 7.6 4.6 1.0 1.0 3.3 2.2 3.5 1.8 1.3 1.70.71 YOR152C 4.5 2.5 3.4 2.9 0.8 4.5 3.2 1.2 10.0 5.0 2.7 2.9 7.4 1.73.6 2.1 4.0 2.2 0.42 YOR173W 0.7 2.3 6.3 2.0 0.9 3.5 4.9 1.4 5.2 3.7 2.31.9 3.8 2.8 0.7 5.7 1.7 3.8 0.54 YOR289W 1.6 1.5 1.0 2.0 1.2 4.2 6.1 2.42.4 1.7 2.6 1.5 4.3 2.0 1.6 3.0 2.3 3.9 0.74 YPR030W 1.7 1.4 1.4 1.0 1.21.3 1.2 0.9 2.5 2.4 1.2 1.4 3.2 1.5 1.5 3.1 1.4 2.1 0.30 YAL008W 1.4 2.42.0 2.4 0.7 1.6 1.9 1.3 1.8 1.5 2.2 1.3 2.2 2.6 0.9 4.2 1.4 1.9 1.04YBR053C 1.0 1.6 2.4 2.4 1.6 2.7 4.1 1.2 2.9 2.1 2.3 1.1 2.4 1.0 0.7 2.81.9 2.4 1.25 YBR099C 1.0 1.4 7.2 1.8 1.0 0.5 0.9 1.5 3.4 12.9 0.4 1.02.1 1.6 0.8 0.5 0.8 0.9 0.47 YBR137W 1.1 2.2 1.4 3.5 0.9 2.4 2.7 2.0 2.21.8 2.4 1.4 2.1 1.8 0.6 2.8 1.4 2.6 1.40 YBR203W 1.4 1.4 1.6 2.4 0.9 0.60.9 1.3 1.1 1.8 1.3 1.6 2.4 1.3 1.0 18.0 1.4 2.2 0.38 YCL049C 1.9 1.31.4 1.2 1.6 2.3 2.1 1.0 2.0 1.9 1.6 1.4 2.4 1.8 1.4 2.1 1.4 1.4 0.86YCR082W 1.4 1.2 0.7 1.2 1.3 1.3 1.5 1.5 4.3 2.3 2.0 1.0 2.0 2.4 1.6 2.21.2 1.7 1.62 YDL054C 1.3 2.2 2.7 1.1 1.2 1.2 0.9 0.7 3.5 2.1 2.1 1.1 2.71.2 1.0 1.0 1.0 1.0 0.92 YDL115C 1.4 1.0 0.5 1.8 0.8 1.5 1.8 1.6 6.6 3.61.8 1.1 1.9 2.3 1.2 1.6 1.3 1.8 0.83 YDL144C 0.8 0.9 1.2 1.5 1.0 1.8 1.00.9 3.6 1.2 1.9 1.0 2.1 1.2 1.0 1.1 0.9 0.9 0.52 YDL223C 0.7 1.1 5.0 2.50.9 0.8 1.0 0.3 3.8 1.5 5.2 1.0 3.1 1.3 3.1 7.2 0.9 1.0 0.32 YDR032C 1.72.2 3.5 2.5 1.4 2.7 2.8 2.4 3.1 2.9 3.3 1.8 2.9 2.8 1.3 3.8 1.9 3.5 3.50YDR330W 0.8 1.5 1.2 0.8 1.2 2.3 1.3 1.1 3.9 2.6 0.9 1.0 2.2 1.1 1.6 1.41.5 1.3 0.53 YDR411C 0.9 2.8 1.8 1.2 1.6 0.8 2.0 0.9 0.7 1.0 1.3 1.5 1.90.8 4.1 1.5 1.5 1.3 0.56 YDR511W 1.3 1.7 0.9 2.3 1.0 2.0 1.5 1.7 2.5 2.21.2 0.8 3.1 2.2 0.8 2.2 1.3 1.5 0.66 YDR545W 0.6 1.2 0.6 0.7 1.4 1.0 1.20.6 1.8 0.7 0.7 0.9 2.0 0.7 0.9 0.9 0.9 0.9 1.06 YER004W 1.0 1.5 1.9 1.41.5 1.2 1.4 1.1 4.5 2.9 2.2 1.7 4.6 1.8 1.4 2.3 1.4 1.2 1.48 YER035W 1.41.6 1.6 1.9 1.5 0.9 1.9 1.2 1.2 1.4 1.4 1.1 1.9 1.0 0.9 2.1 2.2 2.1 0.85YER079W 1.1 1.6 1.9 2.0 0.8 1.5 1.9 1.4 5.3 3.4 2.1 0.9 2.1 1.6 0.5 1.41.0 1.6 0.69 YER158C 1.2 0.9 0.9 3.1 0.8 0.7 1.2 0.9 2.1 1.6 2.3 1.0 3.10.9 0.6 1.6 1.6 1.2 0.61 YER163C 1.1 2.4 1.2 1.6 0.8 2.0 1.5 1.4 5.4 3.41.6 1.0 2.9 1.9 1.6 2.4 1.2 1.2 0.62 YER175C 0.9 1.2 1.3 2.2 0.9 0.8 2.31.1 1.9 11.5 1.1 0.9 4.3 1.1 1.3 2.8 0.9 1.2 0.53 YFL006W 0.8 2.8 1.61.0 1.4 1.2 1.0 1.0 3.2 1.7 1.2 1.2 3.1 1.7 2.4 1.1 1.0 0.8 0.82 YFL010C1.0 4.8 1.3 1.0 1.3 1.9 1.5 1.0 3.1 1.4 1.4 1.5 3.3 1.4 1.7 1.4 1.9 1.60.77 YFL032W 0.4 1.5 1.6 0.8 0.9 0.6 1.1 0.4 0.5 0.6 1.1 0.7 2.4 0.6 2.00.7 1.7 0.8 1.62 YGL037C 1.5 2.7 6.5 2.1 0.9 1.3 2.9 1.2 2.1 1.6 3.9 0.82.3 1.0 0.8 1.5 1.3 2.6 4.58 YGL047W 1.0 1.9 1.6 2.3 1.3 1.5 1.7 1.1 4.55.7 1.9 1.1 2.6 2.3 1.7 2.9 1.1 1.2 0.97 YGL053W 1.5 1.5 1.2 2.5 2.0 2.73.7 1.2 3.3 2.4 1.3 1.3 3.3 1.1 1.1 3.9 2.2 3.7 1.26 YGL199C 1.1 1.7 1.71.0 0.7 0.7 1.3 0.7 0.1 0.9 2.0 0.8 1.6 1.6 1.2 1.0 0.36 YGR101W 1.0 1.31.2 1.1 1.2 0.9 1.5 0.8 4.0 1.4 2.0 1.0 2.4 0.9 1.1 2.0 1.0 1.1 1.04YGR130C 0.9 0.7 0.6 1.6 1.4 0.9 1.3 0.9 2.0 1.5 0.8 0.7 1.9 0.9 1.2 2.21.3 1.6 0.78 YGR154C 1.8 2.9 2.2 0.5 1.2 1.4 2.0 1.7 25.2 9.1 1.5 0.92.5 2.2 0.7 2.0 1.0 1.2 0.36 YGR221C 0.9 2.2 0.9 1.4 0.9 3.0 1.2 1.1 0.70.5 1.6 2.3 1.4 1.5 2.7 1.3 1.3 0.29 YHR138C 2.8 1.8 2.2 2.8 1.5 3.8 3.01.4 5.3 4.6 1.6 1.8 4.0 3.4 2.2 3.3 5.0 7.1 1.89 YHR199C 1.9 2.0 3.2 2.01.2 1.1 1.1 1.0 8.6 6.0 1.9 1.1 2.1 2.0 2.8 3.3 1.1 0.9 0.63 YIL041W 1.01.2 2.1 1.3 0.5 1.0 0.8 0.9 1.8 1.4 1.4 1.0 2.3 1.3 1.3 0.7 0.8 1.1 1.33YIL087C 1.3 1.9 3.4 1.6 1.4 4.1 1.8 1.1 2.4 1.8 2.8 1.1 2.4 1.3 0.4 5.61.7 1.6 0.68 YJL057C 1.5 1.2 1.6 1.7 1.5 1.4 2.7 1.5 7.3 6.1 2.0 1.0 2.51.6 1.4 1.9 1.4 1.5 0.51 YJL066C 0.9 1.2 1.2 2.5 0.8 1.4 1.6 0.8 2.0 2.10.8 1.0 2.2 1.0 1.3 2.8 1.4 1.5 0.43 YJL082W 1.4 0.8 2.4 1.1 1.7 0.2 0.40.9 1.4 2.9 1.0 1.3 2.1 0.5 3.2 0.2 0.6 0.3 2.07 YJL151C 1.0 2.4 3.2 1.21.3 2.2 1.4 0.8 0.5 1.6 1.0 1.3 2.4 1.3 1.0 2.5 3.5 2.4 1.69 YJL152W 0.91.5 1.8 1.3 1.6 1.5 1.2 0.7 0.3 1.0 1.0 1.0 1.8 1.4 0.8 1.6 2.5 1.7 0.80YJL161W 1.7 2.2 1.5 4.6 1.1 8.0 3.6 1.4 3.1 2.1 3.7 1.0 2.5 2.2 0.6 4.41.9 2.1 0.44 YJL171C 2.3 0.7 2.8 1.4 1.0 2.7 1.4 0.9 1.0 1.7 2.2 1.0 2.91.0 1.8 1.0 3.6 2.9 1.94 YJR008W 1.6 1.5 1.2 1.7 1.4 2.2 2.9 1.1 1.8 1.91.4 1.3 2.0 1.2 0.9 3.3 1.5 2.7 0.87 YKL151C 1.2 3.1 1.7 2.5 1.0 2.0 5.61.0 3.3 3.5 2.3 1.0 2.0 1.3 1.4 3.7 1.4 1.8 1.02 YKL153W 1.1 1.4 2.0 0.71.0 2.9 1.1 0.7 0.8 1.4 2.1 1.1 2.4 1.1 1.5 1.1 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1.1 0.7 0.90.8 1.0 0.33 YLR334C 1.2 1.1 1.1 2.3 1.8 1.0 1.4 0.9 1.0 0.8 0.8 0.8 0.92.2 2.5 0.7 0.8 1.0 0.30 YLR408C 1.3 2.3 0.6 2.3 1.4 1.0 1.0 1.4 0.9 1.10.7 0.8 1.1 2.1 0.9 1.1 1.2 1.2 0.79 YLR414C 1.5 1.6 1.4 4.8 1.3 0.6 0.70.9 0.2 1.2 1.2 0.6 1.0 1.0 2.1 0.9 3.9 3.6 2.21 YLR444C 0.9 0.8 1.7 5.90.7 0.7 0.9 0.9 0.2 0.2 1.1 0.6 0.5 1.1 1.3 0.7 0.9 0.9 0.50 YML050W 1.51.2 1.3 2.1 0.8 0.5 0.9 1.1 1.3 1.6 1.2 0.8 0.9 1.9 1.0 1.5 0.8 1.1 0.42YML107C 1.1 0.7 0.4 1.8 2.2 1.1 1.5 1.3 0.6 0.9 0.9 0.7 0.6 1.3 1.0 1.31.2 1.5 0.67 YMR031C 0.7 0.8 1.2 2.1 0.6 0.7 0.8 0.9 1.5 1.1 0.8 0.7 1.01.0 0.7 1.6 0.9 1.3 1.26 YMR204C 1.1 1.9 1.3 2.3 1.0 0.6 0.7 1.0 1.0 2.20.7 0.7 1.1 1.2 1.5 1.1 0.9 1.1 0.31 YMR206W 1.4 1.4 2.3 3.9 1.1 1.0 1.30.9 1.0 9.0 1.8 1.0 1.2 1.4 0.3 2.2 1.0 1.2 0.17 YNL010W 1.5 1.0 0.7 1.91.0 1.2 1.1 1.8 0.5 0.6 1.1 0.9 0.7 1.2 0.9 1.2 1.0 1.7 4.53 YNL127W 1.11.2 0.7 3.6 0.7 1.2 0.8 1.0 2.7 2.2 1.0 1.0 1.7 1.0 1.5 1.4 0.9 1.4 0.36YNL217W 1.1 1.2 0.5 1.7 2.1 1.5 1.3 1.4 0.3 0.9 0.7 1.0 1.0 0.9 0.5 1.01.3 2.1 2.35 YOL118C 2.6 2.2 1.3 2.2 1.5 3.2 1.1 3.2 1.4 0.6 1.7 3.0 1.00.5 0.9 1.0 0.24 YOR053W 1.0 1.1 0.5 1.7 1.7 0.9 1.6 0.9 1.3 0.8 1.3 0.60.9 1.2 1.0 1.3 1.2 1.2 0.77 YOR352W 1.3 0.9 1.0 2.2 1.6 0.9 1.8 1.1 1.72.0 1.1 1.0 1.2 1.3 0.7 2.5 1.3 1.7 0.59 YOR394W 1.2 0.8 2.2 1.6 1.6 1.71.8 1.0 1.1 2.3 1.9 0.9 1.3 0.9 0.9 1.7 1.6 1.1 0.51 YPL033C 0.8 1.0 0.95.1 1.3 0.7 1.0 0.7 0.4 1.6 0.7 0.6 0.7 1.1 0.8 0.4 0.9 0.8 0.23 YPL066W0.9 1.0 1.1 2.0 1.3 1.3 1.3 0.9 0.5 0.8 1.0 1.1 0.9 0.7 0.7 1.2 1.3 1.30.77 YPR014C 1.0 0.7 1.1 7.9 0.8 0.9 0.8 0.9 0.9 0.5 0.7 0.7 1.0 0.9 0.80.9 1.1 0.29 YBR005W 1.9 2.6 1.1 2.9 0.8 0.7 1.2 0.9 0.4 1.3 0.8 1.7 1.90.9 1.1 1.7 2.9 4.6 1.00 YFL027C 0.8 0.8 1.1 1.3 1.1 0.3 0.4 1.1 1.8 1.31.3 0.6 1.1 0.3 1.4 1.2 5.1 5.2 1.74 YGL080W 1.3 1.5 1.1 1.3 1.5 1.4 1.51.2 1.1 1.2 0.8 1.0 0.7 1.6 0.9 1.7 1.3 2.9 1.70 YMR252C 1.1 1.0 1.5 1.31.3 1.0 1.3 1.1 0.9 1.0 1.4 0.8 1.1 1.1 1.1 2.1 1.5 2.2 0.86 YOR385W 2.81.2 0.2 2.5 1.5 1.0 1.2 1.0 1.5 2.2 1.2 0.6 2.8 0.8 0.8 1.2 4.6 5.9 1.17YAR033W 1.0 0.8 1.5 1.1 1.1 1.4 2.1 1.2 1.3 1.6 1.5 0.9 1.5 1.3 0.9 2.01.1 3.0 1.15 YBR151W 0.8 0.8 1.3 1.2 1.2 1.7 1.3 0.8 0.8 0.9 0.9 0.9 1.10.8 1.0 3.0 1.4 2.4 1.83 YHR162W 1.2 1.2 0.9 1.8 1.2 1.3 1.7 1.4 1.0 1.71.3 1.2 1.5 2.0 1.1 1.4 1.3 2.7 3.64 YLR165C 1.4 0.8 1.3 1.1 1.1 1.5 1.41.1 1.7 1.0 1.4 0.9 1.2 1.4 0.5 1.6 1.1 2.1 0.78 YNL157W 1.4 1.1 0.7 1.51.9 0.9 1.3 1.1 1.7 1.4 1.3 0.9 1.6 1.5 1.0 1.0 1.9 2.3 1.41 YOL002C 0.90.7 0.5 1.0 2.0 0.9 0.4 0.8 0.1 0.3 0.8 1.1 0.2 0.5 0.6 1.7 1.5 2.1 5.33YPL233W 1.2 0.9 0.5 1.1 1.4 0.6 1.0 1.0 0.3 0.6 0.9 0.6 1.0 1.0 0.4 1.01.9 1.9 0.48 YGR149W 1.4 1.3 1.8 1.9 1.0 1.7 1.8 0.8 0.6 0.6 1.8 1.2 2.61.0 2.4 1.3 2.0 1.7 0.71 YNL043C 1.0 4.4 1.6 1.3 0.8 0.6 0.9 0.9 0.4 0.40.7 0.9 2.1 1.2 1.6 0.8 2.7 1.6 0.68 YPL067C 1.2 1.6 2.8 1.4 1.0 0.8 1.21.2 0.8 0.9 1.4 0.9 0.7 1.5 1.1 2.9 1.7 0.40 YPL170W 1.2 1.3 0.9 1.1 1.91.1 0.6 1.1 1.4 1.0 1.1 0.9 1.1 1.4 1.2 1.6 2.2 1.4 1.05 YGL051W 1.1 1.01.6 1.7 1.3 1.0 1.3 0.8 1.1 1.8 1.4 1.0 1.5 1.2 0.8 2.6 1.4 1.9 1.06YIL112W 1.1 1.4 2.8 1.9 0.6 1.3 1.1 0.9 1.3 2.0 1.4 1.2 1.1 1.3 1.8 2.41.2 1.3 0.45 YLR052W 1.0 1.5 0.8 1.3 1.0 0.8 1.0 1.2 0.4 1.1 1.1 1.0 0.81.2 1.0 2.4 0.7 0.9 0.77 YNL203C 0.9 1.3 0.3 3.2 1.0 1.7 1.6 0.8 0.3 1.10.9 1.2 2.7 1.2 5.6 1.3 1.7 0.21 YNR014W 1.0 0.8 1.7 1.2 1.2 0.7 1.7 0.90.3 2.3 4.4 0.9 1.5 4.9 1.0 2.4 1.1 1.0 0.31 YAL028W 0.9 0.7 1.1 2.0 1.00.6 1.2 0.8 1.6 1.3 1.0 1.0 1.5 1.6 2.2 1.7 1.0 1.0 0.30 YBL095W 0.8 1.41.2 1.4 1.1 0.9 1.1 0.9 1.0 0.6 1.2 0.8 1.0 1.0 0.4 2.2 1.3 1.9 0.72YBR157C 0.7 1.0 0.4 1.4 1.3 1.2 1.6 0.7 0.6 0.3 0.6 0.6 0.5 0.9 0.2 1.91.3 0.8 0.69 YDL091C 1.1 1.3 1.8 1.4 0.7 0.8 1.3 1.3 1.6 1.5 1.5 1.0 1.31.5 1.9 2.4 1.1 1.6 0.47 YDL216C 1.1 1.1 0.7 2.0 1.6 1.6 1.2 1.6 1.3 1.30.7 0.9 1.2 1.1 1.0 1.8 1.0 1.6 0.42 YDR067C 1.3 1.2 0.7 2.7 0.9 1.1 1.31.8 1.0 1.3 0.9 0.9 1.2 1.5 1.5 2.4 1.3 1.4 0.76 YDR186C 0.7 0.9 0.7 0.71.3 0.7 1.4 1.2 1.2 1.6 0.7 1.1 1.1 0.8 0.8 2.3 1.1 0.9 0.50 YDR196C 0.90.9 0.7 1.1 1.0 1.7 1.7 1.5 1.6 1.1 1.3 0.7 1.2 1.0 0.7 2.7 1.2 1.9 1.54YDR262W 1.3 1.8 0.8 1.2 1.7 1.3 1.7 1.2 0.9 1.7 1.6 0.8 0.9 1.7 1.5 3.81.0 1.4 1.11 YDR306C 0.9 1.2 0.7 1.8 1.7 1.2 1.6 1.3 2.0 1.4 2.1 0.9 1.21.1 1.2 2.4 1.0 1.5 0.77 YDR319C 1.3 0.9 0.8 1.1 1.2 1.2 1.7 1.3 1.1 1.11.3 1.0 1.3 0.8 2.0 2.1 2.2 1.23 YER188W 1.3 0.9 1.2 1.9 0.9 1.5 1.2 0.70.4 0.9 1.2 0.9 1.1 1.1 0.3 2.5 1.0 1.1 0.61 YGL004C 0.8 1.4 1.3 1.0 1.01.4 2.9 1.4 1.8 2.2 1.0 0.8 1.3 0.9 0.6 2.2 1.1 1.4 0.48 YGR141W 0.8 1.61.6 1.7 1.1 1.5 1.5 0.9 0.3 1.0 0.6 0.6 1.0 0.7 2.6 2.1 1.1 1.3 0.65YHR080C 0.6 1.8 1.9 0.7 0.8 1.8 1.1 1.1 1.9 1.2 0.7 1.2 2.0 0.9 0.9 2.31.1 1.3 0.49 YHR097C 1.6 0.7 0.7 0.9 0.8 0.8 0.7 0.4 0.6 0.7 0.8 1.3 0.92.7 2.0 1.7 1.4 0.24 YIL077C 0.9 0.8 1.2 1.2 1.3 1.8 1.2 0.9 1.5 1.4 1.31.6 1.3 1.3 0.9 2.4 1.3 1.1 0.75 YJL046W 0.9 0.9 0.6 1.8 1.0 0.7 1.5 1.11.8 2.7 4.2 0.9 1.3 1.3 1.0 2.5 1.0 1.3 0.68 YLL005C 1.0 1.1 1.1 1.2 1.61.9 1.3 1.0 0.4 1.0 0.9 0.8 1.1 1.7 1.0 2.1 1.1 1.2 0.44 YLR151C 1.4 2.01.4 1.0 1.0 1.4 1.4 1.5 0.9 1.1 0.5 0.7 1.3 0.7 2.4 1.0 1.4 0.30 YLR271W1.6 1.2 0.8 1.8 1.4 1.4 1.7 1.5 1.0 1.0 1.3 0.8 1.2 1.2 1.0 3.0 1.5 1.80.78 YMR025W 1.2 1.2 0.7 1.5 1.3 1.3 1.4 1.2 1.0 1.6 1.2 0.9 1.2 1.8 1.12.4 1.0 1.5 0.42 YMR135C 1.0 1.0 1.1 1.9 1.8 1.0 1.0 1.0 1.1 1.4 1.1 1.01.3 1.0 1.4 2.3 1.5 1.3 1.06 YMR210W 1.0 1.1 1.8 1.9 0.6 0.8 1.1 1.1 1.52.2 0.8 0.9 1.0 1.0 1.0 2.2 0.8 1.5 0.56 YNR040W 0.8 4.9 0.5 0.9 0.9 1.62.1 1.3 1.1 0.8 1.2 0.6 0.8 1.5 0.7 2.1 1.1 1.0 0.30 YPL039W 1.2 0.9 0.61.3 1.4 1.5 1.5 1.4 1.1 1.0 0.9 0.9 1.1 1.1 0.6 2.4 1.1 1.1 0.52 YPL099C1.1 1.9 0.7 2.0 0.9 1.2 1.4 1.4 2.4 1.7 0.8 0.9 1.1 1.3 0.5 2.1 1.0 1.70.92 YPL107W 1.2 0.8 1.1 1.3 1.0 1.1 1.2 1.5 1.4 1.3 1.1 0.7 0.8 1.7 0.71.8 1.0 1.1 0.59 YPL138C 1.1 1.7 1.1 1.8 0.7 0.5 1.1 1.3 1.1 1.5 0.5 0.90.6 1.3 2.7 2.6 0.8 1.1 0.38

TABLE 2 Mitochondria-located protein genes The level of expressed mRNAin the presence of chemical substance/ The level of expressed mRNA inthe absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6)(7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) IntensityYJR048W 1.3 0.9 2.2 1.4 0.8 0.5 0.3 0.9 0.5 1.5 1.0 0.8 0.4 2.5 0.6 1.51.2 1.2 1.19 YOR226C 1.3 2.2 1.7 1.1 1.3 1.2 1.2 1.2 1.3 5.9 1.5 0.6 0.92.7 1.0 0.7 1.0 0.7 0.58 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.5 1.70.9 2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YBL022C 0.4 0.8 1.2 0.7 1.2 1.2 1.00.4 2.8 1.2 1.1 0.9 2.6 1.0 1.5 1.0 0.9 0.7 0.76 YCL057W 0.6 1.5 2.3 0.51.1 1.8 1.4 1.8 4.2 2.1 1.6 1.0 3.8 1.0 2.8 1.5 0.9 1.1 0.76 YDR258C 1.62.3 2.8 1.4 1.3 2.4 3.9 1.9 4.9 13.3 1.7 1.8 5.2 1.5 0.6 1.0 1.3 1.30.87 YGR028W 1.4 3.5 1.0 1.8 0.9 1.5 2.1 1.4 1.7 2.0 1.1 1.5 2.6 1.2 1.02.2 1.5 2.6 0.91 YGR244C 1.0 1.2 1.6 1.6 0.8 2.6 3.9 1.8 1.4 1.1 1.8 1.92.6 1.2 2.0 2.6 1.9 3.1 1.12 YKL142W 1.8 2.7 3.1 1.4 0.7 3.4 6.9 2.3 5.85.9 2.0 1.9 3.3 2.3 1.3 3.3 2.4 3.6 1.68 YNL055C 1.1 1.8 5.5 2.0 0.9 2.61.2 0.7 1.1 1.0 1.9 1.7 2.4 0.9 1.1 2.6 1.2 1.7 4.10 YNL071W 0.9 0.9 1.71.5 0.6 1.3 1.4 0.9 1.1 1.2 1.6 1.3 2.5 0.8 1.1 1.1 1.0 1.2 1.61 YOR020C1.4 2.1 1.7 1.7 1.5 2.3 1.7 1.7 5.8 2.6 2.5 0.8 3.0 1.6 1.5 1.4 1.4 1.71.66 YOR037W 1.0 1.5 0.6 1.4 1.5 1.6 2.5 1.5 1.3 1.0 1.2 1.2 2.1 1.0 0.91.4 1.2 1.6 0.61 YDL198C 1.4 1.0 2.1 1.4 0.7 0.8 1.0 1.1 1.9 2.7 2.5 1.22.0 1.7 1.2 1.4 1.5 1.1 1.19 YDR231C 1.1 1.6 1.0 1.5 1.1 2.2 1.7 1.3 1.51.4 1.3 1.1 2.4 1.5 1.0 3.0 1.2 1.3 0.92 YER178W 0.8 0.9 3.6 1.0 0.7 2.51.6 0.8 1.7 1.3 2.5 1.3 2.4 0.9 1.8 1.0 1.1 0.9 2.18 YFL016C 0.8 1.0 1.60.9 1.3 1.3 1.4 0.7 6.4 2.9 1.2 1.0 2.8 0.8 0.8 0.6 1.2 0.9 1.25 YGR008C2.1 3.0 1.7 3.2 0.9 2.9 3.7 1.9 3.1 2.4 2.6 2.0 3.4 1.3 1.5 2.3 1.7 4.23.03 YIL155C 1.0 0.7 1.4 3.7 1.3 1.4 2.2 1.0 2.5 2.9 1.3 1.4 2.0 1.3 1.43.8 1.1 1.4 0.51 YJL102W 1.1 0.7 0.4 0.8 1.3 1.6 0.6 0.9 3.1 2.2 0.7 0.82.6 1.5 1.5 0.6 1.0 1.1 0.22 YJR045C 0.5 1.9 3.9 0.5 1.2 1.0 0.8 3.2 3.01.4 1.0 2.3 0.5 2.3 0.8 0.7 0.9 3.78 YLR259C 0.7 1.0 3.1 1.6 1.1 0.9 1.80.8 1.8 2.6 3.0 0.7 2.5 0.8 2.1 1.3 0.8 1.0 2.09 YLR348C 1.1 4.5 1.2 1.20.9 1.9 0.9 0.9 2.1 1.3 1.3 0.9 1.9 1.0 2.4 1.1 1.1 1.0 0.64 YML054C 1.51.8 1.3 3.4 1.3 1.8 1.2 1.5 4.1 1.8 1.4 1.8 2.8 2.1 1.1 7.8 1.1 1.6 0.25YMR089C 0.8 1.1 0.9 0.9 0.8 1.2 1.2 1.3 5.6 2.5 1.3 0.8 2.3 0.9 1.8 1.10.9 1.1 0.69 YMR152W 0.9 1.1 1.8 0.9 0.8 7.5 0.8 0.8 2.7 1.3 1.2 1.3 1.91.1 0.6 1.0 1.5 0.9 0.71 YNL104C 1.1 1.3 3.0 0.9 0.8 0.8 0.6 0.9 1.1 2.02.1 1.1 2.1 0.9 2.5 1.5 0.9 0.9 1.69 YOR130C 0.8 1.7 1.4 1.0 1.8 1.6 1.30.8 2.0 1.7 0.6 0.9 2.1 1.3 1.0 0.8 1.5 1.1 0.51 YPR024W 0.7 1.0 1.3 1.01.3 1.0 1.4 0.7 3.0 1.7 0.9 0.8 2.5 0.7 1.0 1.6 1.1 0.8 0.84 YPR067W 1.61.2 1.7 0.9 1.3 1.3 1.5 1.4 3.5 3.4 1.8 1.0 3.0 1.6 1.3 0.8 1.0 1.0 0.66YBR029C 0.7 0.2 1.8 1.0 1.4 0.8 0.4 0.7 2.0 1.1 0.7 1.3 1.7 0.9 3.5 0.90.6 0.8 1.56 YCL009C 0.6 0.9 2.0 0.5 0.7 1.8 1.3 1.1 0.9 1.6 1.5 1.7 1.60.7 6.5 0.9 1.1 0.8 0.68 YER026C 0.8 0.6 3.3 1.0 1.2 2.5 1.6 0.8 0.9 1.50.9 1.7 1.9 1.1 4.0 1.4 1.7 3.2 4.48 YLR109W 0.8 2.9 6.0 0.9 1.3 2.1 2.60.9 2.4 2.7 1.5 1.6 3.2 2.3 3.9 1.8 1.1 1.2 3.86 YMR189W 0.7 0.8 1.9 2.80.4 1.9 0.8 0.4 0.7 0.9 8.2 0.6 0.9 1.6 5.6 0.9 1.0 0.8 0.88 YNL169C 0.71.4 1.4 1.2 0.7 1.4 0.7 0.8 1.1 1.1 0.8 1.0 1.7 0.9 3.4 0.8 1.1 1.3 1.05YER069W 1.3 0.8 3.3 1.4 1.5 1.3 1.0 1.5 0.8 10.4 1.5 0.8 1.4 1.3 2.4 1.11.1 0.9 0.25 YIL022W 0.8 0.7 1.1 1.6 0.8 1.2 0.7 0.8 1.1 1.3 1.0 0.9 1.20.6 2.9 1.1 0.8 0.7 0.52 YBR146W 0.9 0.8 0.7 1.5 1.3 2.6 1.5 1.0 0.9 1.11.2 1.0 1.7 1.2 1.0 2.9 1.0 1.2 1.61 YDR019C 1.4 0.5 1.7 4.0 0.9 4.8 1.40.7 0.4 0.7 1.8 0.7 1.0 1.6 1.8 1.8 1.2 1.6 2.48 YGR207C 1.5 1.1 1.0 1.11.5 2.8 1.7 1.9 2.1 2.6 1.4 1.1 1.0 2.2 0.6 1.8 1.2 1.8 1.49 YMR072W 1.11.0 1.4 1.0 1.7 2.4 1.4 1.0 3.0 1.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06YNL037C 1.4 1.8 1.7 1.1 1.7 2.8 2.8 1.0 0.6 3.2 1.4 1.3 1.9 1.3 0.9 1.40.9 1.3 2.05 YOR136W 1.0 0.9 3.5 1.0 1.5 3.9 3.2 1.1 0.3 3.4 1.4 1.2 1.50.9 1.2 1.3 0.8 1.3 3.20 YPL271W 1.2 3.2 4.1 1.2 1.4 3.3 1.2 0.9 0.6 1.21.7 0.8 1.2 1.3 0.8 1.4 1.2 1.3 1.34 YAL044C 1.5 1.1 1.0 3.0 0.8 2.2 1.00.8 0.4 0.6 1.4 0.6 1.1 1.4 0.7 1.0 1.4 1.8 4.07 YAL054C 1.2 1.1 1.4 1.61.1 2.2 1.1 1.1 8.9 4.1 1.3 1.0 1.8 1.3 0.9 2.5 1.5 1.4 0.24 YBR024W 1.01.0 1.1 2.4 1.0 2.2 1.9 1.4 1.3 1.4 1.3 1.1 1.7 1.9 0.8 2.3 1.0 1.2 1.14YDR405W 0.9 1.1 4.7 1.0 1.1 2.4 1.2 0.9 0.6 1.0 1.0 1.2 1.3 1.1 2.5 1.31.3 0.9 0.44 YGL068W 1.0 0.6 1.1 1.4 0.9 2.6 1.5 0.9 0.7 0.8 1.0 1.1 1.00.9 0.6 1.8 1.8 1.0 3.35 YGR220C 1.1 0.6 0.9 1.1 1.3 2.1 1.4 1.5 0.8 1.51.1 0.9 1.1 1.5 1.1 2.3 0.9 1.1 1.42 YHR037W 0.7 0.9 1.3 1.6 0.9 1.8 1.21.0 0.9 2.2 1.7 1.1 1.1 1.1 1.1 2.0 1.0 1.4 1.15 YIL070C 1.2 1.0 0.8 1.41.3 2.3 1.6 1.1 0.3 0.6 1.0 0.8 0.7 1.3 1.0 2.4 0.7 1.1 1.69 YIL111W 1.61.0 1.8 2.7 2.6 3.2 1.2 1.6 1.1 2.1 0.9 1.7 1.5 1.1 2.5 1.9 3.9 1.52YKL138C 1.2 0.9 0.6 0.9 1.3 2.3 1.9 1.7 1.1 2.1 1.2 0.8 0.8 1.6 0.6 2.51.0 1.3 1.29 YKL150W 1.1 2.0 3.0 1.4 1.4 2.3 2.4 1.3 1.1 1.3 1.9 1.2 1.81.4 0.9 6.1 1.2 2.7 2.20 YKR006C 1.0 0.7 1.2 1.2 1.4 2.4 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1.2 1.2 0.64 YBR122C 0.9 0.9 0.3 1.1 1.5 1.1 2.0 1.3 1.1 1.41.2 0.7 0.8 1.2 0.7 1.9 0.9 1.5 1.53 YBR251W 1.0 0.9 1.0 1.2 1.3 2.0 1.41.3 0.5 1.1 1.5 1.1 1.0 1.6 0.8 3.0 0.9 1.4 1.13 YCR083W 1.1 2.8 1.5 1.81.6 2.4 1.8 1.5 1.8 1.8 1.8 1.1 1.8 2.4 1.0 3.1 1.3 1.3 0.98 YDL067C 1.81.0 1.6 1.3 2.0 0.9 0.8 1.1 0.9 0.9 1.4 1.0 0.6 1.4 0.7 1.8 1.2 1.7 1.85YDR079W 1.3 1.1 0.8 1.1 1.2 1.7 1.3 2.6 0.9 0.8 1.3 1.1 1.3 1.5 0.6 2.61.1 1.3 1.06 YGR062C 0.9 1.0 0.7 1.4 0.7 0.9 1.3 0.8 1.0 1.4 1.6 1.0 1.51.2 0.5 1.8 0.9 1.1 0.54 YJL096W 1.0 1.0 0.8 1.3 1.9 1.0 1.7 1.3 1.0 1.41.2 1.0 0.7 2.1 1.0 2.2 1.1 1.2 1.21 YJL180C 0.9 1.6 1.1 1.3 1.5 1.3 1.61.0 1.4 1.4 1.4 0.8 1.2 1.4 0.6 2.0 0.9 1.4 1.08 YLR295C 1.4 1.1 1.1 1.72.2 1.1 1.1 1.2 1.4 1.2 1.3 0.5 0.8 1.2 0.5 2.4 0.9 1.5 1.07 YMR023C 1.41.3 0.5 1.9 1.7 1.1 1.9 1.4 1.5 2.6 0.8 0.7 1.1 1.6 0.7 2.1 1.1 1.4 0.48YMR267W 0.8 1.8 0.7 0.9 1.0 1.4 1.2 1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.60.9 1.3 0.94 YNL073W 0.8 1.4 0.9 1.7 0.6 0.5 1.1 1.0 0.9 1.8 1.1 0.7 1.20.7 0.7 1.8 0.8 1.0 0.52 YOR316C 0.7 2.5 1.5 1.5 1.0 0.9 1.4 0.8 1.6 2.02.4 1.1 1.6 1.0 1.5 2.2 0.8 1.0 0.93 YPL040C 1.1 1.0 0.8 1.7 0.8 1.1 0.81.1 0.2 1.2 0.9 0.9 1.0 1.1 1.1 2.7 0.8 1.1 0.33 YPL134C 1.5 1.0 1.6 1.61.4 1.2 1.2 1.3 0.6 0.8 1.7 0.8 1.0 1.4 1.1 3.3 1.3 1.3 0.70

TABLE 3 DNA repair protein genes The level of expressed mRNA in thepresence of chemical substance/ The level of expressed mRNA in theabsence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7)(8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YFL014W3.4 5.1 5.7 11.0 1.0 9.3 5.5 3.4 13.1 5.8 5.0 4.3 15.2 7.3 6.3 14.2 1.58.8 2.14 YGL163C 0.9 0.8 0.6 4.3 1.5 0.9 1.0 1.4 5.8 2.3 0.4 0.9 3.1 1.61.8 1.0 0.9 0.8 0.26 YKL145W 0.8 1.4 1.2 1.0 1.4 2.1 1.6 1.5 3.5 2.7 1.81.3 2.7 1.0 1.3 1.2 1.1 1.5 2.29 YIL153W 0.8 1.4 1.3 2.9 1.0 0.9 1.6 0.54.3 1.1 1.0 1.0 1.2 1.0 2.8 1.3 0.9 0.7 0.32 YIR002C 0.8 1.1 0.5 0.6 1.22.2 1.3 1.2 1.7 1.4 0.8 1.3 1.2 1.1 1.1 1.4 1.1 1.2 0.58 YAL015C 1.2 1.11.7 1.9 1.1 0.7 1.2 1.1 4.0 2.7 1.4 1.0 1.2 1.6 0.7 2.0 1.1 1.2 0.61YBR073W 0.7 1.0 0.9 0.7 1.2 0.7 0.6 1.1 2.5 1.8 0.5 0.9 1.4 1.0 1.3 0.80.7 0.8 0.63 YDL200C 1.4 2.0 1.2 1.8 1.1 0.6 1.7 1.5 2.4 1.8 1.2 1.1 1.11.8 0.7 1.8 0.9 1.6 0.79 YGL058W 1.1 1.1 0.6 0.7 1.0 1.0 0.0 1.3 3.7 1.80.8 1.3 1.0 1.3 1.3 0.6 1.1 0.7 1.07 YIL143C 0.9 0.8 1.1 0.9 0.8 1.4 0.80.9 7.1 3.5 1.5 0.9 1.7 1.0 1.3 1.1 0.9 0.9 0.56 YML032C 0.8 0.9 1.1 0.71.0 0.9 0.8 0.9 3.0 1.1 1.0 0.9 1.8 1.0 1.7 1.2 1.0 1.0 0.66 YNL250W 0.92.2 0.8 1.2 0.8 0.8 1.2 1.3 4.2 2.3 1.0 1.4 1.3 1.6 1.3 1.4 1.0 1.0 0.31YOR386W 1.0 0.8 1.3 1.5 1.2 3.3 1.8 1.0 4.1 3.0 1.4 1.2 2.4 0.9 1.3 1.22.1 1.7 0.46 YBL019W 0.9 9.1 0.7 1.2 1.0 1.0 1.2 1.2 2.6 1.4 1.0 0.8 0.91.1 0.6 1.9 0.8 1.1 0.38 YDR369C 1.1 1.1 2.4 1.1 1.0 0.6 0.4 1.0 2.4 1.81.1 0.9 0.1 0.7 1.2 0.6 0.8 0.7 1.88 YEL037C 0.9 2.0 0.9 1.0 0.5 0.6 0.80.8 2.6 1.2 1.0 1.1 2.0 1.0 1.6 0.5 1.0 0.8 0.82 YER162C 1.0 1.2 1.0 1.10.9 0.7 0.5 0.9 2.8 1.6 0.5 0.4 0.8 0.8 1.0 1.0 1.2 0.9 0.45 YGR258C 0.70.9 0.7 0.7 1.5 2.2 1.5 0.8 2.5 1.5 0.3 0.9 1.9 1.2 1.1 1.2 1.0 0.9 0.37YJR052W 1.1 1.0 1.1 1.0 1.0 1.4 1.2 1.7 4.5 2.3 1.1 1.1 1.8 1.4 1.4 1.41.0 1.3 0.36 YOR005C 1.2 1.8 1.0 0.8 1.3 1.3 1.4 1.3 2.4 1.5 1.2 0.9 2.11.2 0.8 1.4 1.1 1.0 0.29 YPL022W 0.7 0.8 0.7 1.2 0.8 5.2 0.8 1.0 2.1 1.60.8 0.7 1.4 0.9 0.9 1.0 0.9 0.9 0.72 YPL164C 1.1 0.7 1.1 1.0 1.2 1.7 0.91.0 2.1 2.0 1.1 0.9 1.0 0.9 1.3 1.4 1.0 1.0 0.25 YPL194W 0.9 1.4 0.4 1.11.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4 0.9 1.0 0.8 0.22 YPR025C 1.10.8 0.6 0.6 1.6 0.9 1.4 1.3 1.9 1.7 0.9 0.7 1.1 1.3 1.1 1.3 1.1 1.5 0.87YGR180C 3.1 1.1 1.9 1.0 2.0 0.6 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3 1.21.0 1.9 3.90 YEL019C 1.1 1.6 0.3 0.7 0.9 1.5 1.2 0.9 0.7 0.7 1.2 1.0 1.01.7 1.5 0.3 0.8 0.9 0.27 YLR288C 1.2 0.8 1.6 1.8 1.7 1.2 1.3 1.5 0.8 1.31.4 0.6 0.7 1.2 0.9 1.5 1.2 1.3 0.31 YMR284W 1.1 1.0 0.5 2.0 0.8 0.8 0.81.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54 YMR035W 1.2 1.7 1.5 1.70.8 1.5 2.3 1.4 1.7 1.6 1.5 0.5 1.4 1.3 1.1 1.5 2.2 2.4 0.96 YOL043C 1.10.9 0.8 1.7 1.2 0.8 1.0 0.9 1.0 1.8 1.2 0.8 0.9 1.5 0.6 2.5 1.0 1.0 0.38YGR231C 1.0 1.2 0.7 1.0 1.3 1.9 2.1 1.1 3.2 2.3 1.6 1.3 3.9 2.2 1.3 2.51.0 1.5 1.74 YHR164C 0.9 1.3 0.9 0.7 0.9 1.4 0.8 1.1 1.3 3.1 0.6 1.2 2.01.3 2.2 1.1 0.8 1.0 0.44 YJR046W 1.0 1.2 1.2 1.5 0.8 2.0 0.9 0.9 6.0 2.40.6 0.9 3.0 1.0 1.1 0.8 0.7 0.7 0.45 YLR103C 0.8 1.5 1.1 0.4 1.0 1.1 1.31.4 0.8 0.5 0.9 1.6 3.0 1.0 0.8 1.5 1.1 1.4 1.32 YMR072W 1.1 1.0 1.4 1.01.7 1.6 1.4 1.0 3.0 1.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06 YDR054C 1.31.0 0.7 1.4 0.7 1.9 1.1 1.5 2.9 3.2 1.9 1.0 2.5 1.1 1.6 1.4 0.8 1.4 1.18YAR007C 0.7 1.9 0.8 0.5 1.5 1.6 0.8 1.1 4.1 1.7 0.9 0.9 1.7 1.4 1.2 0.90.8 1.0 1.03 YGL058W 1.1 1.1 0.6 0.7 1.0 1.5 0.0 1.3 3.7 1.8 0.8 1.3 1.01.3 1.3 0.6 1.1 0.7 1.07 YIL036W 0.9 1.3 1.3 1.8 0.9 1.8 1.4 1.1 3.6 2.71.2 1.2 1.9 1.1 0.8 1.3 1.1 1.3 0.66 YNL213C 1.7 11.6 0.9 1.5 1.3 1.71.4 1.8 3.0 1.5 1.5 0.8 0.9 1.8 1.0 1.7 0.9 1.2 0.70 YNL312W 0.9 1.0 1.60.7 1.4 1.7 0.5 1.2 3.7 2.5 1.4 0.9 0.7 1.1 0.8 0.8 1.2 1.1 2.05 YNL261W1.0 1.3 0.6 1.3 0.7 1.3 1.0 1.1 2.3 1.5 0.8 0.8 0.8 1.4 0.7 1.1 0.8 1.00.91 YGR180C 3.1 1.1 1.9 1.0 2.0 1.0 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.31.2 1.0 1.9 3.90 YJL026W 2.5 2.4 2.9 1.0 1.7 1.0 0.5 1.2 1.0 1.1 1.3 1.01.2 1.0 1.1 1.6 1.4 2.1 3.74 YDL017W 0.8 2.3 1.2 1.3 1.2 1.1 1.1 1.2 0.81.8 0.8 0.8 0.9 1.3 1.3 1.0 0.8 1.0 0.38 YML058W 1.9 1.2 5.8 1.9 0.6 1.30.6 0.7 1.1 1.2 3.3 0.9 1.4 1.1 2.5 1.3 1.3 1.5 2.14 YLR233C 1.1 0.9 2.02.0 1.2 0.8 0.8 1.1 0.6 0.5 0.8 0.9 1.0 1.1 1.1 1.1 1.0 1.2 0.43 YMR284W1.1 1.0 0.5 2.0 0.8 1.2 0.8 1.1 1.6 1.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.30.54 YGL163C 0.9 0.8 0.6 4.3 1.5 0.9 1.0 1.4 5.8 2.3 0.4 0.9 3.1 1.6 1.81.0 0.9 0.8 0.26 YGL127C 1.0 1.9 1.3 1.7 1.3 0.6 1.0 0.9 1.2 1.5 1.0 1.41.7 1.0 1.5 1.3 1.0 1.2 0.54 YMR072W 1.1 1.0 1.4 1.0 1.7 2.4 1.4 1.0 3.01.2 1.9 0.8 2.1 1.2 0.8 1.7 0.9 1.9 2.06 YGL249W 1.4 0.8 0.5 0.8 1.1 2.51.2 0.9 0.3 2.4 0.6 0.8 0.8 1.9 0.7 1.4 1.0 1.0 0.20 YBR272C 0.8 1.8 1.31.0 1.1 1.9 1.1 1.7 2.7 1.1 0.5 1.3 1.0 0.5 1.7 1.1 1.2 0.52 YDL059C 2.65.1 1.4 1.7 1.2 1.2 1.1 1.2 10.5 7.8 2.0 1.3 1.7 4.7 0.7 1.5 0.8 0.90.63 YAR007C 0.7 1.9 0.8 0.5 1.5 0.6 0.8 1.1 4.1 1.7 0.9 0.9 1.7 1.4 1.20.9 0.8 1.0 1.03 YBR073W 0.7 1.0 0.9 0.7 1.2 0.7 0.6 1.1 2.5 1.8 0.5 0.91.4 1.0 1.3 0.8 0.7 0.8 0.63 YML032C 0.8 0.9 1.1 0.7 1.0 0.9 0.8 0.9 3.01.1 1.0 0.9 1.8 1.0 1.7 1.2 1.0 1.0 0.66 YNL250W 0.9 2.2 0.8 1.2 0.8 0.81.2 1.3 4.2 2.3 1.0 1.4 1.3 1.6 1.3 1.4 1.0 1.0 0.31 YCR014C 0.8 1.0 0.80.6 1.2 1.1 1.1 1.0 2.4 1.0 0.8 0.7 1.2 1.0 0.7 1.5 1.0 0.9 0.34 YDR369C1.1 1.1 2.4 1.1 1.0 0.6 0.4 1.0 2.4 1.8 1.1 0.9 0.1 0.7 1.2 0.6 0.8 0.71.88 YIL072W 0.8 3.1 1.1 2.6 1.5 1.2 1.7 1.4 2.9 2.1 1.8 1.1 1.4 2.0 1.41.4 1.0 1.1 0.23 YOR005C 1.2 1.8 1.0 0.8 1.3 1.3 1.4 1.3 2.4 1.5 1.2 0.92.1 1.2 0.8 1.4 1.1 1.0 0.29 YPL164C 1.1 0.7 1.1 1.0 1.2 1.7 0.9 1.0 2.12.0 1.1 0.9 1.0 0.9 1.3 1.4 1.0 1.0 0.25 YPL194W 0.9 1.4 0.4 1.1 1.3 1.11.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4 0.9 1.0 0.8 0.22 YGR180C 3.1 1.1 1.91.0 2.0 0.6 0.5 1.0 1.4 1.5 1.0 0.9 0.9 0.9 1.3 1.2 1.0 1.9 3.90 YEL019C1.1 1.6 0.3 0.7 0.9 1.5 1.2 0.9 0.7 0.7 1.2 1.0 1.0 1.7 1.5 0.3 0.8 0.90.27 YML058W 1.9 1.2 5.8 1.9 0.6 0.6 0.6 0.7 1.1 1.2 3.3 0.9 1.4 1.1 2.51.3 1.3 1.5 2.14 YLR288C 1.2 0.8 1.6 1.8 1.7 1.2 1.3 1.5 0.8 1.3 1.4 0.60.7 1.2 0.9 1.5 1.2 1.3 0.31 YMR284W 1.1 1.0 0.5 2.0 0.8 0.8 0.8 1.1 1.61.8 1.1 0.6 1.0 1.2 0.7 1.3 1.1 1.3 0.54 YMR096W 1.7 1.7 1.1 0.8 1.0 2.21.9 2.0 3.3 3.7 1.5 1.4 8.4 4.7 28.9 2.2 2.2 1.0 0.62 YGL091C 2.0 1.81.0 1.7 0.8 1.6 1.3 1.8 10.8 6.0 2.1 1.2 2.5 3.1 0.7 1.0 1.4 1.8 0.96

TABLE 4 Energy system protein genes The level of expressed mRNA in thepresence of chemical substance/ The level of expressed mRNA in theabsence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7)(8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YCR107W12.1 2.6 1.8 1.6 0.7 1.5 1.5 15.6 196.6 34.0 23.0 0.9 4.0 8.3 4.8 3.11.3 1.1 0.59 YDL243C 14.5 2.7 2.4 1.0 1.1 2.2 1.6 11.8 64.2 29.6 19.61.1 4.1 12.0 4.2 3.0 1.8 1.5 0.76 YFL056C 19.0 2.3 2.3 1.5 0.9 0.6 1.418.5 162.3 31.3 68.3 1.0 4.7 7.8 5.0 3.4 1.0 1.1 0.55 YFL057C 20.9 5.91.5 1.8 0.9 1.2 1.8 18.0 51.8 46.1 27.7 1.0 4.1 23.4 3.1 3.9 1.6 1.30.71 YJR155W 7.6 3.7 1.4 2.5 0.7 1.4 1.7 10.6 38.2 18.8 15.4 1.0 5.7 9.42.6 5.6 1.3 1.4 0.64 YNL331C 8.6 3.6 1.3 1.0 1.6 1.8 1.9 13.1 42.6 36.321.8 0.9 3.1 7.5 2.3 4.0 1.7 1.3 0.58 YOL165C 10.1 4.5 1.8 0.9 0.9 1.71.4 17.8 46.9 23.3 17.6 0.8 3.7 9.1 3.0 1.8 1.6 1.0 0.69 YPL171C 15.24.1 3.5 2.2 1.1 1.3 1.7 20.5 60.0 50.6 37.0 1.4 2.4 9.3 1.4 1.2 2.4 1.50.47 YDL021W 5.1 1.7 2.4 3.7 1.7 6.5 5.9 2.7 2.5 7.4 4.7 2.4 5.3 3.7 0.77.3 1.9 3.2 0.47 YGR043C 2.6 3.7 3.2 7.9 0.9 16.3 6.5 2.6 10.9 8.4 3.63.3 6.9 4.1 3.0 13.7 1.6 4.8 0.66 YHR179W 3.3 2.3 2.6 0.7 1.2 3.7 1.93.3 3.6 5.8 2.0 2.2 2.6 5.8 2.7 1.0 1.9 1.6 2.69 YJR048W 1.3 0.9 2.2 1.40.8 0.5 0.3 0.9 0.5 1.5 1.0 0.8 0.4 2.5 0.6 1.5 1.2 1.2 1.19 YKR097W 1.62.4 1.3 3.3 1.1 1.7 3.7 2.5 1.9 3.3 0.8 1.8 17.5 2.1 2.5 2.2 1.1 1.50.16 YML087C 1.8 1.6 0.8 2.5 0.9 0.9 1.1 1.3 1.9 4.9 1.6 0.8 1.5 2.1 0.32.0 0.7 0.8 0.52 YPL088W 3.3 1.3 0.6 2.5 1.5 7.1 3.7 1.9 0.6 2.8 1.1 3.64.8 1.6 3.2 4.3 9.1 8.3 0.69 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.51.7 0.9 2.8 5.9 1.1 0.6 5.1 2.2 4.0 0.63 YCR012W 1.2 1.5 5.1 1.2 1.1 2.51.4 0.8 1.4 1.5 1.8 1.2 4.1 0.9 1.4 1.4 0.8 1.3 4.48 YFR053C 1.8 1.4 3.02.2 0.9 3.2 2.1 2.8 0.6 1.1 1.5 1.7 3.0 0.6 0.6 3.0 1.4 2.2 4.17 YGL062W0.6 1.3 1.1 0.6 0.9 1.0 1.3 0.8 1.6 2.5 0.7 1.6 4.5 1.2 2.7 1.5 1.1 0.90.77 YGR192C 1.4 1.0 3.8 1.0 1.1 1.7 1.7 1.1 0.9 1.3 2.3 2.2 3.4 1.0 1.91.1 1.1 1.3 7.49 YGR244C 1.0 1.2 1.6 1.6 0.8 2.6 3.9 1.8 1.4 1.1 1.8 1.92.6 1.2 2.0 2.6 1.9 3.1 1.12 YGR254W 1.2 1.3 3.8 1.3 1.2 1.9 1.5 1.4 0.81.2 1.3 1.7 3.1 0.6 2.4 1.4 1.3 1.2 7.01 YIL160C 0.8 2.4 2.3 3.5 1.0 1.61.1 1.2 3.2 3.8 2.4 1.0 2.3 1.5 5.6 8.8 2.4 3.0 0.27 YJL052W 1.6 0.9 4.01.8 0.7 2.4 2.1 1.5 1.6 2.0 4.3 2.4 5.6 1.3 2.3 2.3 1.2 1.9 6.19 YJR009C1.1 1.7 5.6 1.0 1.2 1.6 1.6 1.1 1.1 1.3 1.1 1.5 2.7 1.0 2.1 1.5 1.1 1.35.86 YLR345W 1.4 1.4 1.4 1.2 1.2 1.6 1.2 1.4 4.5 4.0 2.5 1.6 3.5 1.5 1.01.2 1.2 1.4 2.65 YMR118C 1.3 2.9 1.4 1.6 1.2 2.0 1.0 1.0 9.3 1.4 0.7 0.84.2 0.9 0.9 8.1 0.8 1.0 0.38 YNL071W 0.9 0.9 1.7 1.5 0.6 1.3 1.4 0.9 1.11.2 1.6 1.3 2.5 0.8 1.1 1.1 1.0 1.2 1.61 YNL241C 1.3 2.5 4.3 1.0 0.8 0.93.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.8 1.0 1.0 0.68 YPL240C 0.7 1.4 2.40.9 1.3 1.2 1.4 1.2 3.5 2.6 1.0 0.8 2.9 0.7 1.2 0.7 0.8 1.0 4.83 YAL060W1.1 1.8 3.2 2.7 1.2 4.2 3.3 0.9 0.6 2.5 2.4 0.8 2.2 0.9 0.9 3.2 1.1 1.82.39 YCL040W 0.9 5.6 10.1 2.0 0.5 3.5 2.9 0.7 0.9 3.0 8.2 2.3 5.6 0.73.4 3.1 1.4 1.7 1.98 YDR001C 1.0 2.2 2.6 1.0 1.1 2.2 1.5 0.9 2.2 3.0 0.71.1 2.8 1.0 4.4 1.9 1.1 1.6 0.75 YDR231C 1.1 1.6 1.0 1.5 1.1 2.2 1.7 1.31.5 1.4 1.3 1.1 2.4 1.5 1.0 3.0 1.2 1.3 0.92 YER178W 0.8 0.9 3.6 1.0 0.72.5 1.6 0.8 1.7 1.3 2.5 1.3 2.4 0.9 1.8 1.0 1.1 0.9 2.18 YGR008C 2.4 3.01.7 3.2 0.9 2.9 3.7 1.9 3.1 2.4 2.6 2.0 3.4 1.3 1.5 2.3 1.7 4.2 3.03YGR256W 1.2 1.5 2.3 0.8 0.9 6.2 1.4 2.2 3.4 2.5 2.7 1.5 3.9 1.1 2.7 5.31.1 0.8 0.94 YHL008C 0.9 0.5 1.0 1.6 0.8 0.8 0.7 0.9 1.6 1.7 1.4 0.8 1.81.0 1.8 0.9 0.8 0.9 0.40 YHR174W 1.1 1.4 3.3 1.2 1.3 1.5 1.6 1.2 1.0 1.51.4 1.5 3.6 0.6 2.0 1.1 1.0 1.2 7.34 YIL045W 1.7 1.4 1.9 2.2 1.3 1.7 1.61.1 2.1 3.2 1.2 1.5 2.0 1.6 0.6 2.9 1.1 1.8 0.37 YKL035W 1.0 0.9 4.8 1.20.8 1.2 0.6 1.0 0.8 1.2 2.1 1.0 2.0 0.6 1.0 1.5 1.0 1.9 2.54 YKL152C 1.41.3 1.9 0.9 1.3 1.6 1.5 1.0 0.9 1.5 1.7 1.5 2.7 1.0 1.8 2.0 1.1 1.7 3.28YML054C 1.5 1.8 1.3 3.4 1.3 1.8 1.2 1.5 4.1 1.8 1.4 1.8 2.8 2.1 1.1 7.81.1 1.6 0.25 YML100W 0.8 2.7 10.6 1.4 0.9 2.8 2.2 0.7 1.7 1.4 3.2 1.23.8 1.2 1.8 2.2 1.0 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1.32.5 1.2 1.8 1.2 37.3 0.6 1.1 0.6 1.04 YOL086C 1.1 0.5 2.2 1.1 1.9 1.71.9 0.8 0.1 1.2 2.6 1.3 1.7 0.6 1.6 1.4 1.1 1.3 4.19 YOR142W 1.3 1.2 3.41.0 1.4 1.6 1.0 0.8 1.1 1.5 1.5 0.8 1.4 0.8 1.1 0.8 0.9 1.0 1.31 YPL061W0.4 1.4 5.0 1.3 1.6 1.7 0.5 0.8 1.3 0.7 1.1 1.0 1.1 0.6 1.7 1.0 1.6 2.63.23 YDL107W 1.3 1.3 1.0 2.2 1.0 1.3 1.8 1.8 1.2 1.8 1.0 1.0 1.2 1.5 1.02.0 1.1 1.5 0.51 YDR529C 1.8 1.0 0.9 3.2 1.2 0.8 0.5 1.3 0.5 0.6 0.8 0.60.7 1.5 0.5 1.8 1.0 2.3 3.11 YGL018C 1.5 1.0 1.8 3.0 1.1 0.4 1.1 0.8 0.51.4 1.1 1.0 1.3 1.2 1.1 1.5 0.8 1.0 0.36 YBR185C 1.5 1.0 1.3 2.0 0.8 1.21.2 1.1 0.9 1.6 1.2 0.7 1.0 1.7 1.0 1.7 0.8 1.3 0.89 YEL039C 1.1 0.7 1.35.1 0.9 1.5 0.6 1.1 1.2 1.2 1.7 0.6 0.5 1.4 0.4 3.5 0.7 1.1 1.59 YGR174C1.1 1.6 0.6 2.4 1.0 1.4 1.0 1.6 1.8 0.7 1.3 0.9 1.5 1.6 0.7 3.2 1.3 2.31.05 YKL016C 1.5 1.3 0.7 1.7 1.5 0.8 1.5 1.6 1.3 1.8 1.3 1.0 1.3 1.6 0.71.8 1.0 1.7 2.08 YLR395C 1.8 1.3 2.2 1.9 0.7 0.4 1.0 1.0 0.9 1.5 0.6 0.51.7 0.4 1.2 1.2 2.3 1.76 YML120C 1.1 1.2 1.9 1.9 0.6 0.6 0.8 0.9 1.3 1.51.3 0.9 1.2 0.8 0.5 1.5 1.0 1.6 0.74 YMR073C 1.1 1.1 1.2 1.5 0.8 0.9 1.01.1 1.2 1.2 0.9 0.8 1.2 2.0 0.9 1.5 0.8 1.2 0.69 YOR388C 1.0 1.6 1.3 4.71.3 1.4 1.0 0.7 0.1 1.4 1.3 0.7 1.1 1.3 4.0 0.8 1.0 0.9 0.21 YPL275W 0.61.5 1.3 5.1 1.2 1.0 1.1 1.0 0.2 1.2 0.9 0.6 1.0 1.0 1.4 0.9 1.0 1.0 0.28YPL276W 1.2 1.5 1.6 3.0 1.5 1.1 1.2 0.9 −0.2 1.8 −0.4 0.6 0.9 0.9 1.00.6 1.1 0.8 0.22 YGL205W 1.0 0.9 0.7 0.8 1.1 1.6 0.8 1.2 0.5 0.6 0.4 1.11.0 1.0 2.0 4.1 3.9 9.1 0.24 YJL166W 2.1 1.5 1.6 1.3 1.6 0.7 0.8 1.4 1.31.2 1.4 0.7 0.8 1.9 0.5 2.3 1.7 4.0 2.31 YNL202W 0.7 1.3 1.2 1.7 0.9 2.00.9 1.2 1.3 1.1 1.2 0.9 1.8 1.0 1.4 4.2 2.4 3.3 0.47 YDR377W 1.3 1.1 1.31.4 1.9 1.3 1.1 1.3 1.0 0.9 1.4 0.9 0.7 1.4 0.6 1.8 1.2 2.5 3.00 YGL187C1.5 0.8 1.6 1.8 1.3 1.1 0.6 0.7 0.6 0.6 0.7 0.8 0.7 0.9 0.3 1.4 0.9 2.42.73 YJL216C 1.1 4.7 2.2 0.9 0.8 1.5 1.9 1.5 1.3 1.1 1.0 1.1 1.1 1.2 1.51.2 2.0 0.25 YKR009C 1.0 1.2 1.5 0.9 1.0 1.8 1.0 0.9 2.4 2.1 1.2 1.0 1.81.0 1.0 4.6 1.9 2.5 0.27 YCR046C 1.0 1.2 1.2 1.6 1.0 0.8 1.2 0.9 1.9 1.41.5 1.1 1.5 1.3 1.4 2.8 1.3 1.0 0.63 YML129C 1.1 0.9 0.9 1.2 1.7 1.7 1.81.2 1.4 2.2 1.2 0.8 1.0 1.4 1.1 2.9 1.3 1.3 1.04 YPR184W 1.2 1.4 5.7 2.20.9 1.5 1.3 0.7 1.9 3.2 3.6 1.4 2.5 1.3 1.5 3.1 1.0 1.7 0.37 YDL067C 1.81.0 1.6 1.3 2.0 0.9 0.8 1.1 0.9 0.9 1.4 1.0 0.6 1.4 0.7 1.8 1.2 1.7 1.85YDL078C 0.7 1.1 1.2 0.8 1.3 1.1 1.7 1.0 1.1 1.0 1.7 0.8 1.0 0.8 0.5 2.21.1 2.0 1.65 YDR079W 1.3 1.1 0.8 1.1 1.2 1.7 1.3 2.6 0.9 0.8 1.3 1.1 1.31.5 0.6 2.6 1.1 1.3 1.06 YGR062C 0.9 1.0 0.7 1.4 0.7 0.9 1.3 0.8 1.0 1.41.6 1.0 1.5 1.2 0.5 1.8 0.9 1.1 0.54 YKR058W 1.3 0.9 1.4 1.9 0.8 1.4 1.41.5 1.3 1.2 1.5 0.9 0.7 1.3 0.5 2.6 0.8 1.6 0.73 YLR295C 1.5 1.1 1.1 1.72.2 1.1 1.1 1.2 1.4 1.2 1.3 0.5 0.8 1.2 0.5 2.4 0.9 1.5 1.07 YMR267W 0.81.8 0.7 0.9 1.0 1.4 1.2 1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94

TABLE 5 Transport facilitation protein genes The level of expressed mRNAin the presence of chemical substance/ The level of expressed mRNA inthe absence of chemical substance yeast genes (1) (2) (3) (4) (5) (6)(7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) IntensityYBR008C 3.0 2.4 4.9 0.7 0.9 1.0 0.9 2.8 54.6 21.1 9.4 0.8 2.0 4.1 0.83.1 2.0 1.2 0.37 YBR296C 7.0 4.3 2.2 2.5 1.4 1.4 0.2 1.1 0.4 1.8 1.5 1.62.0 2.3 1.7 0.3 3.8 4.0 0.54 YDR406W 0.8 1.2 3.1 1.1 1.0 5.9 1.8 0.6 1.11.7 1.4 3.9 7.7 0.5 0.8 5.5 2.7 5.6 0.53 YOR153W 1.6 0.9 5.1 1.1 1.0 7.42.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91 YGR281W 1.2 1.01.3 2.2 0.6 1.9 0.9 0.7 2.7 1.4 0.7 2.4 12.9 0.9 2.1 1.1 2.8 3.1 1.04YHL047C 0.6 4.4 1.0 1.0 1.2 8.4 16.8 1.5 1.2 11.9 1.0 2.6 3.8 0.5 1.12.3 1.2 1.2 0.74 YBR294W 6.3 14.4 0.9 2.6 1.4 1.2 1.1 1.0 5.2 5.2 1.21.0 3.1 1.3 1.0 0.9 1.0 0.9 0.18 YGL006W 2.5 1.3 1.3 2.6 1.0 1.0 1.3 0.93.0 1.2 0.8 0.9 4.5 0.9 1.1 1.7 2.4 4.1 1.37 YGR197C 1.1 2.4 2.5 1.0 0.70.5 1.3 0.8 16.7 3.2 1.1 1.2 2.4 1.5 1.0 1.5 1.7 1.9 0.37 YJL034W 0.71.7 3.0 0.8 1.2 1.1 1.3 1.5 2.8 1.1 1.3 1.6 6.1 0.6 7.9 0.6 1.1 1.0 4.58YNL055C 1.1 1.8 5.5 2.0 0.9 2.6 1.2 0.7 1.1 1.0 1.9 1.7 2.4 0.9 1.1 2.61.2 1.7 4.10 YBR052C 1.6 1.6 1.5 2.6 1.4 2.1 3.0 1.3 2.3 2.5 1.7 1.3 2.11.5 0.7 3.1 1.8 3.1 2.77 YBR207W 0.8 1.7 0.8 2.0 1.7 1.6 4.3 0.9 1.7 2.21.1 0.9 2.2 0.9 1.4 1.4 1.2 1.4 1.39 YBR293W 1.9 3.1 1.0 1.8 0.8 0.9 0.90.9 5.5 2.4 1.1 1.0 3.0 1.4 3.1 1.6 1.0 0.9 0.94 YDL198C 1.4 1.0 2.1 1.40.7 0.8 1.0 1.1 1.9 2.7 2.5 1.2 2.0 1.7 1.2 1.4 1.5 1.1 1.19 YDL245C 1.02.4 1.6 2.2 1.3 1.1 1.2 1.2 0.4 2.8 1.5 1.0 2.0 1.2 1.8 1.5 1.0 1.1 0.28YDR497C 0.7 0.5 0.6 1.3 0.7 0.6 0.5 0.6 0.4 0.8 0.7 0.9 2.7 0.6 10.1 1.61.8 1.45 YER053C 1.6 1.8 1.9 1.7 0.6 2.8 2.8 1.3 1.3 3.9 2.4 1.7 4.1 1.31.1 2.8 1.2 2.3 1.83 YFL041W 0.7 1.6 1.4 1.2 1.2 2.0 3.4 1.0 0.8 5.1 0.91.1 1.8 1.0 0.9 1.4 1.1 0.9 0.89 YGR055W 2.5 5.7 12.0 0.7 1.3 1.1 0.61.1 5.0 2.4 1.5 0.9 1.9 1.2 2.1 0.6 0.7 0.7 1.42 YJL219W 1.2 2.5 3.1 1.61.2 1.5 0.9 1.5 4.0 2.3 2.3 1.1 4.0 1.1 2.6 1.4 1.6 1.2 0.91 YJR106W 0.93.8 1.5 1.1 0.9 1.2 1.0 0.9 2.0 1.6 1.6 0.9 3.5 0.9 1.2 1.9 1.2 1.3 0.29YKL146W 0.8 1.3 1.3 0.9 1.0 1.3 0.9 0.8 4.6 2.8 0.9 1.1 2.7 1.0 1.5 1.31.0 0.9 0.42 YLL028W 0.6 0.9 4.6 0.5 0.9 1.7 1.0 0.7 1.2 2.3 0.7 1.3 4.10.7 3.1 0.6 1.2 1.2 1.02 YLR348C 1.1 4.5 1.2 1.2 0.9 1.9 0.9 0.9 2.1 1.31.3 0.9 1.9 1.0 2.4 1.1 1.1 1.0 0.64 YOL119C 2.6 4.8 1.5 2.3 1.5 0.9 2.22.0 5.0 7.4 3.4 0.9 1.6 2.4 4.7 2.8 1.4 1.0 0.37 YOL163W 1.5 3.2 2.1 3.30.9 0.5 0.9 1.1 7.5 6.2 1.6 1.0 2.4 1.2 1.0 1.4 0.8 0.8 0.30 YOR035C 1.21.2 0.3 1.2 1.0 1.9 1.3 1.0 1.3 1.7 1.0 1.1 2.5 0.9 3.8 1.8 1.6 2.1 0.52YOR130C 0.8 1.7 1.4 1.0 1.8 1.6 1.3 0.8 2.0 1.7 0.6 0.9 2.1 1.3 1.0 0.81.5 1.1 0.51 YOR273C 0.7 1.0 1.7 1.0 1.1 0.4 0.4 0.6 0.6 0.5 1.5 0.8 2.60.5 0.8 0.6 3.2 3.1 1.20 YOR332W 1.1 1.0 1.0 1.0 0.9 1.8 0.9 1.5 1.8 1.11.5 1.0 2.2 1.1 1.2 1.2 1.3 1.7 3.58 YCR098C 1.6 3.0 1.7 2.0 1.4 1.6 1.21.0 1.4 2.4 1.3 1.3 1.4 1.1 11.0 0.8 1.7 1.6 0.22 YGR138C 1.1 1.6 1.01.2 0.8 0.8 0.7 1.0 0.5 1.0 0.7 0.6 0.6 0.9 4.5 0.7 0.7 0.7 1.24 YBR295W1.4 1.5 3.3 1.1 0.8 1.6 0.9 1.2 3.3 1.1 0.9 1.8 1.1 4.8 1.4 1.3 1.2 0.27YGL255W 0.7 0.9 0.9 0.8 1.4 1.1 1.0 0.7 0.3 5.0 0.5 0.7 0.2 1.0 2.6 0.50.6 0.5 1.36 YHL035C 0.7 1.3 0.9 1.9 0.9 4.1 1.7 1.1 0.6 4.6 0.9 1.4 1.10.8 3.1 2.4 1.1 1.2 0.77 YIL022W 0.8 0.7 1.1 1.6 0.8 1.2 0.7 0.8 1.1 1.31.0 0.9 1.2 0.6 2.9 1.1 0.8 0.7 0.52 YLR378C 0.7 0.9 2.6 0.5 1.0 1.2 0.70.5 1.1 0.7 1.0 1.2 1.6 0.4 5.9 0.4 0.9 0.7 1.23 YCL038C 1.6 1.6 1.4 1.61.2 3.2 1.5 1.2 1.1 0.9 2.0 1.3 1.9 1.3 2.0 1.8 1.4 1.5 1.04 YFL054C 1.61.1 1.4 2.2 1.3 2.4 1.1 1.5 2.0 2.3 1.7 1.2 2.3 0.9 1.4 1.3 1.7 1.4 1.06YHL040C 1.6 4.9 1.5 0.4 1.1 7.3 4.0 1.5 1.1 11.3 1.7 2.0 2.0 1.1 3.4 1.01.4 1.0 0.69 YKR039W 1.4 3.5 1.3 1.7 1.0 2.8 1.0 1.0 1.9 2.0 1.9 1.5 1.31.2 1.7 1.9 0.9 1.1 0.40 YPL271W 1.2 3.2 4.1 1.2 1.4 3.3 1.2 0.9 0.6 1.21.7 0.8 1.2 1.3 0.8 1.4 1.2 1.3 1.34 YBR068C 1.1 1.0 1.9 2.5 1.4 1.9 1.00.8 2.5 0.8 0.8 2.2 1.8 1.6 5.5 1.1 1.3 1.99 YCR037C 0.7 1.0 0.8 0.8 1.31.8 1.0 0.7 0.6 0.6 0.8 0.7 1.3 0.8 1.0 1.1 1.4 0.9 0.74 YDL128W 0.8 1.12.1 1.0 1.0 2.3 0.9 0.8 0.5 0.7 1.2 0.9 1.6 0.7 1.1 1.0 0.9 1.0 2.80YDR270W 0.7 1.5 1.4 1.3 1.0 2.2 1.7 1.2 2.9 3.6 1.0 1.0 1.8 1.0 1.4 1.10.9 0.7 0.38 YEL065W 0.3 3.8 1.2 0.4 1.4 2.3 4.3 0.9 0.1 4.9 0.6 1.7 0.80.4 2.2 2.6 0.7 0.6 2.10 YGL008C 0.6 0.7 3.1 0.9 0.8 1.9 1.4 0.7 0.0 0.40.7 2.4 1.9 1.2 1.0 2.1 1.1 1.0 4.08 YGL104C 0.8 2.0 2.1 1.8 1.0 2.1 1.20.8 4.6 2.1 1.8 1.1 2.0 1.0 0.9 1.7 1.3 1.3 0.58 YGL167C 0.9 0.7 1.6 1.31.2 2.0 1.2 0.8 1.3 1.1 0.8 1.1 1.5 0.8 1.3 1.3 1.4 1.4 1.41 YGR065C 0.81.5 2.6 1.1 1.2 2.4 2.4 1.0 1.2 2.6 1.1 0.5 0.8 1.3 1.2 1.1 0.7 0.7 0.68YHR092C 2.3 1.0 7.5 2.5 1.4 1.7 0.5 1.5 0.2 0.9 1.5 1.0 0.5 1.6 0.2 1.20.9 1.3 6.09 YIL088C 0.9 2.1 2.1 1.3 1.6 2.2 1.7 0.8 1.0 1.7 1.8 0.9 1.51.2 1.2 1.8 1.2 1.4 1.89 YNL259C 1.6 3.5 1.1 1.2 1.1 3.9 3.8 1.5 1.6 2.11.6 0.7 1.1 1.4 0.7 1.7 2.6 2.4 1.22 YOR270C 0.7 0.5 2.0 0.8 0.8 1.8 1.00.6 0.4 0.9 1.5 0.7 1.3 0.7 1.1 0.8 0.9 0.9 3.49 YPL265W 0.7 0.4 2.3 1.11.0 2.3 8.9 2.3 0.2 1.2 1.8 0.9 1.1 1.1 1.2 2.0 0.5 0.4 1.42 YPR124W 0.20.4 0.3 1.4 2.0 2.0 2.9 2.7 0.2 1.5 2.0 0.8 0.6 0.4 1.1 2.4 1.0 1.3 2.57YER119C 0.7 2.1 1.8 0.7 0.8 1.3 0.8 0.6 5.8 1.2 2.2 0.7 1.6 1.0 2.3 0.81.0 0.9 0.32 YFL055W 2.0 6.7 1.3 2.5 1.5 1.1 1.4 1.3 23.9 6.5 2.7 0.91.3 1.5 0.7 1.4 1.4 1.0 0.23 YLL055W 2.6 19.0 4.8 1.7 1.0 1.4 1.7 1.419.1 14.0 3.6 0.7 1.5 1.3 0.7 2.8 1.1 1.3 0.47 YHL036W 2.2 4.8 3.4 2.01.3 1.3 1.0 1.2 9.0 4.4 2.3 1.2 1.5 1.2 0.9 1.1 1.0 1.0 0.60 YHR048W 2.51.4 1.4 1.7 1.0 0.8 0.8 1.9 4.5 2.7 2.0 0.9 1.1 1.7 0.9 1.4 0.7 0.9 0.26YKL221W 1.3 0.7 2.0 1.0 1.0 0.9 1.3 1.2 7.3 2.7 1.9 0.7 1.6 1.4 1.1 1.30.8 0.9 0.27 YLR092W 5.0 5.6 1.4 0.6 1.3 1.0 1.3 1.5 12.7 5.8 3.1 1.01.8 1.4 0.9 1.2 1.0 1.1 0.24 YML116W 4.1 1.3 1.5 1.4 1.2 0.9 1.4 2.2 1.43.1 4.3 0.5 0.8 2.0 1.9 1.0 1.0 1.0 0.94 YBR291C 2.0 0.9 1.0 1.5 0.9 1.10.9 2.2 0.9 1.0 1.1 0.9 1.0 1.7 0.5 1.5 0.9 1.3 1.19 YCL069W 0.9 4.5 0.90.8 0.9 1.4 1.3 1.2 6.9 1.0 0.9 0.8 1.3 1.4 0.9 1.0 1.0 0.25 YJR095W 1.220.5 1.9 6.7 1.2 1.5 2.0 0.9 0.5 6.3 0.6 0.7 0.8 1.3 0.8 0.8 1.3 0.90.23 YKL188C 1.3 0.7 1.9 2.4 1.0 0.8 1.1 0.7 2.5 2.8 1.1 1.2 1.2 2.1 1.42.7 1.1 1.5 0.27 YKL217W 1.8 2.4 1.0 2.1 1.1 1.2 1.6 1.1 0.9 4.1 1.6 0.81.2 1.2 2.2 3.0 1.7 3.3 0.29 YKR105C 0.8 0.9 0.9 1.5 1.0 1.2 1.0 1.3 1.05.2 0.0 0.8 2.5 1.2 1.5 0.7 0.8 1.0 0.26 YOL158C 0.7 4.0 2.4 0.9 1.2 2.01.6 0.7 1.7 6.1 0.7 0.9 1.4 1.0 0.9 1.2 1.4 1.7 1.30 YPL224C 1.0 2.2 1.32.5 0.6 1.3 2.2 1.3 3.2 4.2 0.8 1.1 1.3 1.4 1.0 2.5 1.3 1.9 0.64 YPR201W33.2 0.9 1.1 1.0 1.2 1.9 0.8 0.9 8.3 5.6 2.2 0.7 1.1 1.8 0.8 0.9 0.8 0.90.29 YAL067C 2.7 12.1 1.5 1.4 0.7 1.2 0.8 1.1 7.6 2.9 1.2 1.0 1.1 1.32.4 1.6 1.0 1.0 0.33 YDL149W 0.8 2.0 1.2 1.6 1.5 1.0 0.7 1.2 3.2 2.0 1.20.7 1.5 1.2 1.8 1.4 0.8 1.0 0.33 YJL094C 1.0 1.7 1.3 2.0 1.4 1.3 1.7 0.85.4 2.9 1.1 1.2 2.6 1.0 1.0 1.8 2.1 2.0 0.84 YLL061W 3.6 2.8 9.2 0.4 0.80.8 0.9 1.4 3.7 5.5 1.7 0.7 0.9 1.3 1.4 1.0 0.6 0.7 0.33 YPL274W 0.8 4.23.8 0.8 0.6 1.1 0.7 0.9 4.1 3.6 2.0 0.5 0.6 0.9 1.5 1.1 0.7 0.6 0.41YBR241C 0.9 9.3 2.6 0.9 0.9 1.5 1.4 0.7 29.8 2.2 1.4 1.4 1.4 0.9 1.6 0.71.0 1.2 1.25 YDL206W 0.9 1.7 1.8 1.4 1.1 5.7 2.0 1.1 1.6 1.5 0.6 1.0 1.31.0 1.1 3.1 1.0 1.1 0.35 YDR040C 0.7 1.4 3.7 0.8 1.0 1.7 0.7 0.8 2.0 1.20.8 0.9 1.8 0.9 0.8 1.4 1.4 1.6 1.25 YFR045W 1.1 1.6 1.1 1.1 1.0 1.0 0.61.0 2.2 1.0 1.4 1.0 1.1 1.0 1.1 0.6 0.9 0.8 0.84 YIL170W 1.1 1.0 2.5 2.20.9 8.8 0.5 1.2 5.7 3.2 1.7 0.7 1.9 1.1 2.3 1.8 1.6 1.5 0.48 YKL192C 1.11.0 3.7 1.1 1.1 1.8 1.1 0.9 3.5 1.6 1.1 1.2 1.7 1.5 1.2 2.1 1.0 0.8 1.57YKL209C 1.0 1.0 1.3 0.8 1.2 3.3 0.9 1.4 2.4 1.6 0.8 0.9 1.4 1.1 1.0 1.11.1 1.0 0.30 YKR106W 1.3 0.8 2.1 1.4 1.2 1.6 0.9 1.3 10.5 7.4 1.8 0.81.4 1.7 2.8 0.9 0.8 0.16 YMR056C 1.1 1.3 1.7 1.0 1.1 0.9 1.4 1.2 1.8 1.11.6 0.9 0.9 1.1 0.7 2.4 1.0 1.1 0.72 YPL147W 1.0 0.8 2.3 1.2 1.2 1.1 1.00.9 2.4 2.4 1.3 0.9 1.5 1.0 2.4 2.5 1.5 3.6 0.33 YIL166C 1.9 12.5 2.11.2 1.0 1.9 1.3 2.5 2.9 1.8 0.9 1.5 1.1 1.3 0.7 1.2 0.9 0.26 YMR058W 0.35.1 2.1 0.3 0.8 2.6 1.8 0.8 0.2 1.4 0.8 0.8 0.4 0.3 0.5 0.4 0.6 0.5 1.66YNL142W 0.7 2.4 2.5 0.8 1.3 0.9 1.1 0.8 0.9 0.6 0.9 1.2 0.9 0.8 0.3 1.01.0 0.9 0.44 YDL210W 1.2 2.2 2.7 1.1 0.9 1.3 0.8 1.1 1.2 1.4 0.6 0.8 1.21.1 1.9 0.9 1.1 0.9 0.20 YCL025C 1.1 4.6 2.5 1.7 0.9 0.9 0.7 0.7 0.3 0.31.0 1.1 0.5 0.7 0.8 0.6 0.6 0.6 1.98 YJL212C 0.8 3.2 3.1 0.5 1.2 1.1 0.70.7 1.1 1.3 0.9 0.4 1.0 0.8 0.3 0.5 0.6 0.5 0.59 YBR132C 0.9 1.9 2.4 1.80.8 1.2 1.1 0.8 0.8 1.1 1.9 1.0 1.4 1.1 1.5 1.3 1.1 1.3 0.43 YBL030C 1.00.9 4.5 0.9 0.7 1.1 0.9 0.8 0.4 0.9 1.1 0.9 0.5 0.8 1.8 1.0 1.0 1.1 3.12YCR024C-A 0.8 0.9 3.2 0.9 1.2 0.8 0.8 0.2 0.7 1.5 1.0 0.5 0.8 1.3 1.50.9 1.4 4.02 YDR342C 2.8 1.1 12.2 5.7 1.6 1.1 0.8 1.2 0.2 2.2 2.9 1.00.6 0.9 0.5 2.4 1.0 2.2 5.23 YDR343C 1.2 1.0 20.6 4.6 1.3 1.3 0.7 1.20.3 2.1 2.3 1.0 0.8 0.8 0.5 2.8 1.1 2.3 5.81 YEL027W 1.2 0.6 3.4 1.1 1.01.1 0.8 0.9 0.9 1.1 0.9 0.9 0.7 1.4 1.5 1.6 1.0 1.4 4.75 YHR094C 0.7 1.25.3 1.6 1.1 1.6 0.8 1.2 0.3 1.2 0.6 0.9 0.7 0.6 2.7 0.9 1.4 1.4 4.82YHR175W 0.8 2.0 2.4 1.5 0.9 1.0 1.6 0.9 0.6 2.0 1.1 1.4 1.2 0.7 1.3 2.31.3 1.2 1.01 YIL056W 1.1 0.9 6.2 1.4 1.2 1.0 0.6 0.7 1.2 1.6 0.7 1.0 1.51.0 0.5 0.9 1.5 1.2 0.71 YMR203W 0.8 0.7 3.0 1.4 0.6 1.1 0.8 0.7 0.7 1.22.3 0.7 1.1 0.7 1.2 0.9 0.8 0.7 1.62 YBL099W 0.8 0.9 3.1 1.4 1.0 0.9 0.90.8 0.9 0.7 2.1 1.0 0.9 0.6 1.0 0.9 0.7 1.2 3.49 YBR127C 0.8 0.7 2.2 1.11.4 1.1 0.9 1.1 0.6 1.3 1.1 0.9 0.9 0.6 1.3 1.4 0.8 1.0 4.59 YDR038C 0.61.3 3.1 0.9 0.9 1.8 0.7 0.9 1.4 0.9 0.9 0.7 2.0 0.8 0.8 1.4 1.3 1.5 1.32YDR039C 0.6 1.6 3.2 0.9 1.3 1.1 0.8 0.6 1.8 1.0 0.9 0.8 1.8 0.9 1.2 1.41.1 1.6 1.39 YDR298C 1.3 1.2 2.6 1.3 1.3 1.2 1.0 1.2 1.0 1.6 1.2 1.1 1.21.5 0.8 2.0 1.1 1.6 2.69 YDR345C 0.8 0.9 5.6 2.6 1.3 1.2 1.1 1.2 0.2 1.11.5 1.4 1.2 0.8 0.8 1.0 1.3 1.8 5.65 YEL063C 0.7 0.8 2.4 1.3 1.2 1.3 0.70.6 0.8 1.7 0.8 1.1 1.1 0.8 1.3 1.0 0.7 0.7 1.12 YFL011W 1.2 0.7 3.7 3.31.3 1.0 0.8 0.8 0.3 1.6 2.1 0.9 0.8 0.8 1.7 1.2 0.8 1.0 1.25 YGR082W 1.00.9 2.2 1.0 0.9 1.1 0.9 0.8 0.6 0.9 1.3 0.8 0.5 0.9 1.2 1.3 0.9 0.8 1.47YGR191W 0.8 0.7 1.6 1.5 0.8 1.1 0.7 0.7 0.1 0.7 1.6 0.7 1.0 0.7 1.5 0.70.8 0.8 1.58 YGR260W 0.6 0.7 3.4 0.8 0.8 0.9 0.9 0.5 0.3 0.4 1.3 0.6 0.50.7 1.8 1.0 0.9 0.9 1.71 YHR026W 0.9 1.0 1.9 1.0 1.1 1.3 0.9 1.6 1.1 0.91.4 0.7 0.7 1.3 2.4 1.2 0.9 1.1 3.40 YJR077C 1.1 1.1 2.0 1.6 0.9 0.9 0.70.8 0.4 0.7 1.6 1.0 0.9 0.7 1.5 0.7 1.0 0.8 1.79 YJR121W 0.9 1.1 3.3 1.00.8 1.5 1.0 0.7 0.8 1.3 0.9 0.8 1.0 0.7 0.9 1.2 1.1 1.4 3.99 YLR081W 1.30.8 2.8 3.6 1.0 0.9 0.7 0.9 0.1 2.2 2.6 1.0 0.6 1.0 0.7 1.2 0.7 0.9 1.46YMR011W 1.3 1.0 9.4 5.5 0.9 0.6 0.8 1.1 0.0 0.7 1.5 0.8 0.4 0.6 0.6 1.21.3 1.6 4.95 YOL156W 1.1 0.7 2.5 1.1 1.2 1.2 1.0 1.0 2.3 2.1 1.1 0.9 1.70.9 1.9 0.9 0.9 0.9 0.53 YPL036W 0.5 0.8 2.8 0.9 1.3 0.7 0.3 0.5 0.1 0.30.8 0.5 0.3 0.6 1.0 0.7 0.4 0.5 3.66 YGR096W 1.5 1.0 1.1 4.6 1.2 1.7 0.91.0 0.8 0.8 0.8 0.8 1.1 1.2 0.9 0.8 0.8 1.0 0.49 YIL006W 1.0 1.1 1.4 2.90.8 0.3 0.8 0.6 0.9 1.1 1.0 0.9 0.8 1.0 1.5 1.7 0.8 0.9 0.28 YKL016C 1.51.3 0.7 1.7 1.5 0.8 1.5 1.6 1.3 1.8 1.3 1.0 1.3 1.6 0.7 1.8 1.0 1.7 2.08YKR067W 0.8 2.6 1.5 2.5 1.3 1.8 2.0 0.8 1.6 2.3 1.3 1.0 1.3 1.3 1.3 2.00.8 1.0 0.58 YMR162C 0.8 1.1 1.1 2.0 0.9 1.0 0.8 0.8 0.7 1.0 1.7 0.7 0.91.0 1.0 0.8 0.8 1.1 0.32 YOR348C 1.1 0.7 1.2 2.0 0.9 0.7 0.8 0.8 0.5 0.41.1 0.7 1.1 1.2 1.6 1.7 0.9 0.9 0.18 YPR192W 0.9 1.1 0.9 5.0 1.2 0.9 0.90.6 0.7 1.3 0.7 0.5 1.1 0.7 1.7 2.6 1.6 0.9 0.28 YPR194C 2.2 1.4 0.5 2.91.3 1.5 0.7 1.0 0.5 0.6 0.7 0.7 1.0 1.0 0.4 0.8 1.0 0.9 0.27 YDR086C 1.31.0 1.2 1.4 1.0 0.8 2.0 1.9 0.6 0.8 1.1 0.7 0.7 1.5 2.1 1.3 1.4 1.9 2.60YGR224W 0.9 1.2 1.2 1.2 1.4 0.8 0.4 0.6 0.9 0.9 0.8 0.6 0.8 0.9 1.1 1.02.8 1.3 0.27 YDR387C 0.8 0.9 1.2 2.2 0.9 1.2 1.3 0.7 1.4 2.0 2.0 0.9 1.30.9 1.4 2.7 1.2 1.1 0.86 YFL050C 0.7 1.0 1.1 2.2 1.0 0.9 0.8 0.9 0.5 1.61.2 0.9 1.2 1.0 1.4 2.3 0.8 1.0 0.36 YBR298C 1.1 1.0 1.6 2.3 1.4 0.4 1.70.5 0.3 1.1 1.5 1.1 0.8 0.9 0.2 2.1 0.9 0.8 0.88 YLR295C 1.4 1.1 1.1 1.72.2 1.1 1.1 1.2 1.4 1.2 1.3 0.5 0.8 1.2 0.5 2.4 0.9 1.5 1.07 YNR072W 1.11.5 0.5 0.7 1.0 0.9 1.5 0.9 0.7 1.8 1.4 1.0 1.5 1.0 1.8 2.1 1.3 1.0 0.26YOR316C 0.7 2.5 1.5 1.5 1.0 0.9 1.4 0.8 1.6 2.0 2.4 1.1 1.6 1.0 1.5 2.20.8 1.0 0.93 YOR328W 1.0 1.0 1.0 1.0 2.9 1.1 1.8 0.8 3.3 2.1 0.19YPL134C 1.5 1.0 1.6 1.6 1.4 1.2 1.2 1.3 0.6 0.8 1.7 0.8 1.0 1.4 1.1 3.31.3 1.3 0.70

TABLE 6 Stress protein genes The level of expressed mRNA in the presenceof chemical substance/ The level of expressed mRNA in the absence ofchemical substance yeast genes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10)(11) (12) (13) (14) (15) (16) (17) (18) Intensity YBR072W 18.5 17.4 18.410.5 1.2 32.2 6.6 2.1 29.4 43.4 6.3 16.3 38.5 5.8 4.9 23.1 1.8 2.2 0.59YFL014W 3.4 5.1 5.7 11.0 1.0 9.3 5.5 3.4 13.1 5.8 5.0 4.3 15.2 7.3 6.314.2 1.5 8.8 2.14 YLL060C 12.5 4.2 2.3 2.6 0.9 1.4 2.0 5.8 13.0 23.214.1 1.1 1.8 10.6 1.5 3.6 1.9 2.3 0.57 YAL005C 0.6 1.6 7.0 0.9 1.2 1.61.2 0.9 3.9 1.8 1.0 1.2 5.0 0.4 1.6 0.7 0.8 0.5 5.23 YBL075C 1.3 4.3 3.11.6 1.1 0.8 1.3 0.8 60.3 6.7 1.6 1.1 8.0 1.1 2.6 2.2 1.2 0.7 1.17YBR169C 1.0 2.1 3.9 1.9 0.8 4.9 2.5 0.9 7.0 4.3 2.2 1.7 7.2 1.1 1.6 2.41.3 1.6 1.10 YCL035C 2.0 2.3 1.5 1.7 1.5 5.1 2.7 1.4 1.9 2.3 2.1 1.5 2.82.5 1.9 5.5 2.6 4.2 1.74 YCR060W 0.7 0.9 0.8 3.3 2.4 1.2 0.7 1.1 1.2 1.78.6 1.7 3.3 1.2 1.7 1.04 YDR155C 1.1 1.5 3.2 1.8 0.8 1.5 1.2 1.4 1.3 1.33.8 1.4 3.3 1.0 2.5 1.6 1.2 2.5 4.99 YDR258C 1.6 2.3 2.8 1.4 1.3 2.4 3.91.9 4.9 13.3 1.7 1.8 5.2 1.5 0.6 1.0 1.3 1.3 0.87 YER103W 0.7 2.1 5.22.1 1.1 1.7 1.0 0.9 20.3 9.0 1.8 1.9 9.0 0.9 3.2 1.2 1.4 0.6 2.10YKL210W 0.5 1.7 2.7 0.7 0.8 1.4 1.0 0.9 3.5 2.9 1.4 1.3 2.9 0.8 1.0 0.90.7 1.1 2.29 YLL024C 0.5 1.6 5.3 0.8 0.7 1.0 1.1 0.7 2.8 2.4 1.6 1.0 4.80.4 1.3 0.5 0.5 0.6 5.12 YLL026W 1.8 2.9 7.7 1.7 0.9 1.9 2.9 1.4 11.46.6 1.7 1.9 8.1 0.8 0.9 1.6 1.7 2.5 2.56 YNL160W 2.1 3.7 10.6 2.0 1.35.8 2.4 1.2 3.5 2.7 5.4 1.4 6.0 1.3 0.7 4.0 1.0 1.0 1.77 YNL241C 1.3 2.54.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.8 1.0 1.0 0.68YOR027W 0.7 2.4 4.4 0.8 1.0 1.6 1.3 0.9 3.5 4.0 1.3 1.3 5.1 0.8 1.4 0.60.9 0.8 1.52 YPL240C 0.7 1.4 2.4 0.9 1.3 1.2 1.4 1.2 3.5 2.6 1.0 0.8 2.90.7 1.2 0.7 0.8 1.0 4.83 YDR293C 0.9 0.9 1.2 1.4 0.6 0.9 0.9 0.6 1.2 1.21.1 0.9 2.3 0.8 1.7 1.6 1.4 1.3 1.12 YDR436W 0.9 0.9 1.1 1.4 0.7 1.1 1.20.9 3.5 1.1 2.0 0.9 2.7 1.2 0.8 1.4 0.9 1.2 0.53 YDR519W 1.3 3.2 1.7 1.60.7 1.3 1.9 1.4 0.5 1.2 1.2 1.7 2.5 1.3 2.0 1.5 1.8 2.4 2.01 YEL030W 0.70.9 1.9 1.1 0.4 0.6 0.9 0.7 2.3 2.5 1.7 0.9 2.7 0.7 0.8 0.8 0.9 0.6 1.28YER125W 0.6 1.1 1.5 0.9 1.4 0.7 0.8 0.7 0.6 1.2 1.0 0.7 1.9 0.7 0.8 1.01.0 1.0 1.48 YFL016C 0.8 1.0 1.6 0.9 1.3 1.3 1.4 0.7 6.4 2.9 1.2 1.0 2.80.8 0.8 0.6 1.2 0.9 1.25 YFR052W 1.1 1.6 1.3 1.5 1.4 3.2 2.2 1.5 3.7 3.00.9 1.8 3.8 3.3 1.4 2.7 1.2 1.9 1.62 YHR057C 1.1 1.2 0.7 0.9 1.3 1.3 1.31.0 2.6 1.2 1.6 1.1 1.9 1.9 1.2 2.2 1.6 1.3 1.07 YIR037W 1.4 2.2 2.0 2.30.6 2.7 1.8 1.3 6.2 3.8 3.0 1.3 2.4 2.3 1.0 4.0 1.7 2.9 1.97 YIR038C 1.33.5 4.6 2.0 0.7 2.5 2.0 1.3 4.6 4.5 3.4 1.1 2.5 2.5 1.2 6.0 2.8 2.0 1.11YJR045C 0.5 1.9 3.9 0.5 1.2 1.0 0.8 3.2 3.0 1.4 1.0 2.3 0.5 2.3 0.8 0.70.9 3.78 YLL039C 1.1 1.0 1.7 1.2 0.9 1.5 1.1 1.1 3.4 1.5 1.1 1.0 2.2 1.43.0 1.1 1.6 2.1 3.60 YLR259C 0.7 1.0 3.1 1.6 1.1 0.9 1.8 0.8 1.8 2.6 3.00.7 2.5 0.8 2.1 1.3 0.8 1.0 2.09 YML070W 0.9 1.7 2.5 1.9 1.4 2.2 3.1 1.34.5 3.9 1.5 1.3 3.3 1.3 0.9 2.6 1.2 1.3 1.03 YPL106C 0.6 1.7 2.4 1.1 1.21.6 1.1 1.2 4.9 1.8 1.3 1.1 3.1 0.9 1.1 0.5 0.5 0.5 3.34 YPR026W 0.9 1.25.0 1.3 0.8 1.3 1.0 0.9 3.1 1.6 1.2 2.3 1.5 3.1 2.5 0.9 1.3 0.26 YDR077W1.2 1.0 3.5 2.1 0.8 1.0 0.7 0.8 0.7 0.7 6.8 0.8 1.0 0.3 6.1 1.0 1.4 1.14.77 YKL163W 1.1 1.4 3.4 1.9 0.6 1.1 0.9 0.8 0.7 1.6 1.3 0.9 1.5 0.516.8 3.0 0.8 1.0 2.01 YLR109W 0.8 2.9 6.0 0.9 1.3 2.1 2.6 0.9 2.4 2.71.5 1.6 3.2 2.3 3.9 1.8 1.1 1.2 3.86 YOR208W 1.3 1.0 1.2 2.9 1.4 1.8 1.11.0 1.5 2.0 1.2 1.2 1.5 1.3 4.4 1.9 1.6 1.6 0.56 YDR098C 0.8 1.4 1.0 0.81.5 1.1 1.5 1.2 3.7 1.5 1.4 1.3 1.2 1.5 2.2 0.8 1.0 1.2 1.59 YHR030C 2.10.8 0.6 2.9 1.8 0.9 1.8 1.5 0.6 2.5 1.5 0.7 1.0 1.1 3.4 1.4 2.0 1.8 1.05YJL159W 1.0 1.3 2.8 1.1 1.0 1.8 0.9 0.8 0.5 1.2 1.2 1.0 1.7 0.6 5.3 1.01.4 0.9 2.45 YMR173W 1.5 3.6 3.0 0.9 1.1 5.0 2.4 2.3 2.7 8.2 3.2 1.4 2.02.3 2.5 1.2 1.9 1.8 1.37 YCR021C 5.2 1.4 4.2 8.6 0.9 2.2 0.9 0.8 2.2 1.00.6 0.5 0.9 1.6 0.5 0.6 0.7 0.8 1.36 YDL022W 0.9 2.6 6.9 1.5 0.7 2.1 1.50.8 1.2 1.8 2.8 1.2 1.5 0.8 0.9 1.1 1.0 1.4 1.79 YDR033W 1.1 1.3 4.6 1.51.1 6.7 0.8 1.0 0.3 1.0 0.7 1.0 0.7 1.0 0.8 1.0 0.7 1.0 5.78 YFL020C 1.01.1 1.9 1.2 1.1 2.0 1.4 0.7 1.3 1.4 1.2 1.3 1.4 1.0 1.4 0.9 1.5 0.9 0.70YGL073W 1.0 2.1 0.9 1.0 1.7 1.9 1.3 0.8 1.9 2.4 0.8 0.8 1.5 1.2 0.9 1.12.5 1.2 0.66 YIL033C 0.8 1.3 3.3 1.3 0.7 2.0 1.1 0.7 2.4 1.3 1.8 1.1 2.50.7 1.0 2.0 1.0 1.2 1.18 YMR021C 1.0 0.7 0.9 1.1 1.6 2.2 2.5 1.3 0.6 1.30.9 0.8 1.4 1.3 1.0 2.0 3.3 3.4 1.14 YBR126C 0.8 1.9 5.6 1.2 0.7 2.9 2.30.6 1.7 1.1 1.3 2.1 0.7 1.0 1.7 1.5 1.3 1.96 YBR067C 1.6 2.5 2.8 0.9 1.11.1 1.1 1.1 1.7 1.0 3.1 1.0 0.9 0.7 3.3 2.5 0.5 0.4 1.76 YDR513W 2.2 2.52.3 2.6 0.9 2.1 1.6 1.6 4.6 3.1 2.0 0.9 1.8 2.0 1.3 3.8 1.3 3.2 3.10YGR088W 1.3 1.2 7.7 2.4 1.0 1.3 0.8 0.8 1.5 3.2 3.9 1.1 1.2 1.3 0.7 5.60.9 2.0 0.75 YHR104W 1.0 4.1 15.7 1.9 1.1 1.2 1.5 1.1 4.8 2.3 2.6 1.01.2 1.5 1.6 1.3 1.9 1.9 1.57 YKL161C 4.2 0.8 0.9 2.2 1.4 2.0 2.0 1.9 1.41.7 3.1 0.9 1.3 1.4 1.3 1.1 1.4 1.9 0.45 YPL223C 4.8 20.0 1.2 5.1 0.91.5 1.1 1.2 29.4 16.5 1.8 0.9 2.3 2.5 1.5 19.0 1.0 1.3 0.31 YBR054W 1.91.8 5.4 1.7 0.8 1.1 0.6 2.1 0.4 1.2 1.8 0.7 1.5 1.0 0.6 0.4 0.7 0.7 3.02YAL015C 1.2 1.1 1.7 1.9 1.1 0.7 1.2 1.1 4.0 2.7 1.4 1.0 1.2 1.6 0.7 2.01.1 1.2 0.61 YDL025C 1.7 5.0 3.5 1.5 0.6 0.6 1.0 1.1 3.6 4.5 1.5 0.9 1.21.7 1.0 1.7 1.0 1.4 0.56 YML007W 0.9 0.8 0.9 1.3 1.0 0.5 1.1 1.9 2.1 2.51.3 1.1 1.7 1.2 1.0 1.4 1.0 1.4 1.54 YER042W 3.0 2.2 3.1 1.0 1.1 1.6 1.11.7 6.8 2.1 1.8 1.1 1.4 5.2 1.0 1.9 0.7 1.1 1.80 YOL064C 1.4 2.1 1.1 0.60.9 1.4 1.2 1.0 8.7 2.7 1.0 0.9 2.0 0.9 1.0 1.7 1.2 1.3 1.32 YGL181W 0.90.9 1.2 1.1 1.1 1.9 1.3 1.2 2.7 2.3 1.2 1.0 2.8 1.0 1.5 1.3 1.0 1.3 0.98YJL128C 0.8 1.4 0.4 0.8 1.2 1.3 1.8 0.9 2.0 1.7 0.6 1.0 1.7 0.8 1.2 0.91.0 1.0 0.42 YJL165C 1.0 0.8 1.3 1.6 1.1 0.5 0.8 0.7 2.8 1.0 1.7 0.9 1.50.9 1.0 1.5 1.3 1.8 0.87 YJR090C 0.8 1.0 0.6 0.8 1.2 1.2 0.8 0.8 1.9 1.20.4 0.8 2.2 1.0 1.6 0.8 1.1 1.0 0.60 YMR186W 0.6 1.4 2.0 0.9 1.3 1.3 1.20.8 2.6 1.3 1.1 1.0 2.4 0.6 1.3 0.6 0.7 1.1 6.64 YNL064C 0.9 1.8 1.8 1.10.9 0.8 0.6 1.4 2.4 1.8 0.9 0.8 1.1 0.8 0.7 0.3 0.7 0.7 3.79 YOR008C 0.70.8 1.4 1.1 1.4 1.1 0.8 0.8 1.9 1.0 1.0 0.7 0.9 0.9 0.9 1.2 0.8 1.3 1.75YPL194W 0.9 1.4 0.4 1.1 1.3 1.1 1.5 1.3 9.6 3.1 0.9 0.9 1.4 1.1 1.4 0.91.0 0.8 0.22 YBL093C 1.0 2.0 0.4 1.4 1.0 0.8 1.3 1.6 0.7 1.1 1.3 1.1 2.11.0 0.5 0.9 1.4 1.3 1.47 YKR053C 0.9 2.0 1.0 1.2 1.0 1.1 1.7 0.9 0.8 1.80.5 0.7 0.7 1.3 0.3 0.9 2.8 2.4 0.35 YJL158C 0.9 0.6 2.8 1.5 1.4 0.5 0.40.7 0.2 0.5 1.9 1.1 0.4 0.5 1.7 0.6 1.4 1.4 3.48 YER057C 1.2 2.0 3.0 1.80.8 1.6 1.4 1.0 0.6 1.4 1.8 1.5 1.0 1.4 1.7 2.8 1.1 1.8 2.03 YHL046C 1.11.7 2.1 1.3 0.9 0.8 1.3 1.0 1.0 2.1 0.4 1.1 1.4 1.4 1.0 1.4 0.9 0.9 0.55YIL011W 0.7 0.5 3.9 0.6 1.1 0.7 0.6 0.7 0.0 0.5 2.5 0.6 0.5 0.5 0.9 1.00.8 0.8 0.57 YKL164C 0.6 1.1 2.5 0.9 1.1 1.4 0.8 0.8 0.4 0.7 1.0 0.8 0.90.3 1.2 1.1 0.8 0.8 2.75 YNR076W 1.3 1.3 2.5 1.0 1.2 1.2 1.2 1.0 1.3 2.51.4 0.7 0.9 0.8 1.1 0.8 1.5 0.8 0.42 YOL161C 1.2 1.1 2.4 1.4 0.9 1.0 0.90.8 0.7 2.0 1.5 1.3 1.2 0.9 1.1 1.6 1.1 1.0 0.89 YOR009W 0.9 0.8 3.2 0.70.8 0.9 0.6 0.7 0.4 0.5 1.4 0.4 0.4 0.7 0.6 0.8 0.9 0.8 0.36 YOR010C 0.70.7 3.2 0.6 1.2 0.5 0.4 0.5 0.6 0.7 1.2 0.5 0.5 0.4 0.6 1.1 1.4 0.6 0.61YPL059W 1.2 0.9 2.6 1.3 1.2 1.3 0.7 1.4 2.0 1.3 1.6 0.8 0.7 1.3 1.0 2.11.8 1.3 1.35 YBR044C 0.8 1.4 0.7 1.9 1.4 1.0 1.5 1.1 0.8 1.2 1.1 0.8 1.20.9 0.9 1.4 0.9 1.3 0.57 YEL039C 1.1 0.7 1.3 5.1 0.9 1.5 0.6 1.1 1.2 1.21.7 0.6 0.5 1.4 0.4 3.5 0.7 1.1 1.59 YGL115W 0.9 0.6 1.2 2.0 1.2 1.2 1.41.0 1.2 1.2 1.0 0.9 0.7 1.2 0.7 1.7 0.8 1.2 2.46 YLR006C 0.7 0.7 0.9 6.21.6 0.9 1.1 0.9 1.1 1.1 1.5 0.7 0.8 1.0 0.9 0.8 1.6 1.0 0.40 YPR005C 1.30.8 1.5 3.8 1.0 0.8 1.2 1.2 2.8 2.0 0.4 0.6 0.7 1.3 2.7 0.8 1.0 1.1 0.24YHL028W 0.7 0.8 1.4 0.5 1.1 1.8 2.1 0.4 0.2 0.4 0.7 1.5 2.1 1.3 0.6 2.61.6 2.5 0.62 YCR083W 1.1 2.8 1.5 1.8 1.6 2.4 1.8 1.5 1.8 1.8 1.8 1.1 1.82.4 1.0 3.1 1.3 1.3 0.98 YPL140C 0.9 1.3 0.9 1.0 0.8 0.3 1.4 1.1 0.9 0.90.8 0.8 0.9 1.1 0.7 1.8 0.9 1.4 0.46

TABLE 7 Metabolism protein genes The level of expressed mRNA in thepresence of chemical substance/ The level of expressed mRNA in theabsence of chemical substance Inten- yeast genes (1) (2) (3) (4) (5) (6)(7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) sity YCR107W12.0 2.6 1.8 1.6 0.7 1.5 1.5 15.6 196.6 34.0 23.0 0.9 4.0 8.3 4.8 3.11.3 1.1 0.59 YDL243C 14.4 2.7 2.4 1.0 1.1 2.2 1.6 11.8 64.2 29.6 19.61.1 4.1 12.0 4.2 3.0 1.8 1.5 0.76 YFL014W 3.4 7.2 5.7 11.0 1.0 9.3 5.53.4 13.1 5.8 5.0 4.3 15.2 7.3 6.3 14.2 1.5 8.8 2.14 YFL056C 19.0 2.3 2.31.5 0.9 0.6 1.4 18.5 162.3 31.3 68.3 1.0 4.7 7.8 5.0 3.4 1.0 1.1 0.55YFL057C 20.9 5.8 1.5 1.8 0.9 1.2 1.8 18.0 51.8 46.1 27.7 1.0 4.1 23.43.1 3.9 1.6 1.3 0.71 YJR155W 10.6 3.7 1.4 2.5 0.7 1.4 1.7 10.6 38.2 18.815.4 1.0 5.7 9.4 2.6 5.6 1.3 1.4 0.64 YNL331C 8.6 3.6 1.3 1.0 1.6 1.81.9 13.1 42.6 36.3 21.8 0.9 3.1 7.5 2.3 4.0 1.7 1.3 0.58 YNL332W 1.1 1.51.1 2.0 1.6 1.1 2.1 1.5 3.3 2.1 2.6 1.2 2.1 3.0 5.4 2.2 1.0 1.0 0.24YOL165C 10.1 4.5 1.8 0.9 0.9 1.7 1.4 17.8 46.9 23.3 17.6 0.8 3.7 9.1 3.01.8 1.6 1.0 0.69 YPR167C 5.3 5.8 1.9 0.8 1.4 2.6 1.2 5.5 76.6 9.0 1.91.3 1.9 4.2 0.9 0.9 1.7 1.4 0.54 YBR256C 3.0 1.4 0.6 1.3 1.6 2.0 2.1 2.318.1 6.8 3.2 1.7 3.5 5.6 1.6 3.0 2.6 3.3 1.97 YBR296C 7.0 11.2 2.2 2.51.4 1.4 0.2 1.1 0.4 1.8 1.5 1.6 2.0 2.3 1.7 0.3 3.8 4.0 0.54 YDL021W 4.81.7 2.4 3.7 1.7 6.5 5.9 2.7 2.5 7.4 4.7 2.4 5.3 3.7 0.7 7.3 1.9 3.2 0.47YFL061W 1.5 1.4 2.1 3.0 1.0 0.5 1.2 1.2 3.2 9.9 1.1 0.9 1.2 6.0 2.1 1.01.2 0.9 0.31 YGR043C 2.5 4.7 3.2 7.9 0.9 16.3 6.5 2.6 10.9 8.4 3.6 3.36.9 4.1 3.0 13.7 1.6 4.8 0.66 YHR112C 1.8 3.1 0.7 1.4 1.3 2.9 3.4 1.710.5 4.4 1.5 1.9 3.9 2.4 2.0 2.7 1.6 1.8 0.55 YIR030C 1.4 1.0 0.9 1.30.9 0.5 1.2 1.4 5.4 2.1 1.4 0.9 1.3 2.9 0.7 0.8 0.9 1.0 0.42 YJR010W 9.17.3 4.9 0.8 1.1 2.5 1.4 3.1 30.0 11.1 2.9 1.4 3.2 5.4 1.7 1.7 1.2 1.00.56 YKL001C 6.8 21.4 5.6 1.8 0.8 0.9 1.1 3.4 10.3 3.4 2.6 2.1 1.6 6.21.1 1.8 2.7 1.7 0.91 YKR097W 1.3 2.4 1.3 3.3 1.1 1.7 3.7 2.5 1.9 3.3 0.81.8 17.5 2.1 2.5 2.2 1.1 1.5 0.16 YLR303W 7.3 9.8 12.1 1.1 1.1 3.0 3.65.3 18.6 5.6 9.8 4.3 9.9 3.8 5.8 3.4 1.5 1.4 1.42 YNL274C 1.4 18.7 2.61.9 0.7 4.2 2.0 2.3 6.3 5.3 4.0 1.1 2.3 3.3 2.5 6.4 1.4 2.6 0.85 YOL151W6.7 3.8 9.1 1.3 1.3 8.4 4.4 6.7 22.8 17.0 9.0 4.6 16.9 4.0 2.8 3.7 4.05.6 1.12 YOR226C 1.3 2.2 1.7 1.1 1.3 1.2 1.2 1.2 1.3 5.9 1.5 0.6 0.9 2.71.0 0.7 1.0 0.7 0.58 YJL153C 1.3 1.7 1.7 17.6 0.7 0.8 2.3 1.3 3.9 2.50.7 10.2 38.0 1.4 37.0 1.0 6.5 1.8 0.27 YOR153W 1.6 0.9 5.1 1.1 1.0 7.42.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91 YPL088W 3.3 1.30.6 2.5 1.5 7.1 3.7 1.9 0.6 2.8 1.1 3.6 4.8 1.6 3.2 4.3 9.1 8.3 0.69YDL124W 2.1 8.5 5.7 1.7 0.7 3.4 2.9 2.1 3.3 5.3 3.4 2.4 6.0 1.6 3.4 3.62.2 2.6 2.43 YDL174C 0.9 1.8 0.9 1.3 0.5 1.7 3.6 0.8 0.5 1.7 0.9 2.8 5.91.1 0.6 5.1 2.2 4.0 0.63 YGL156W 1.3 2.5 1.8 2.2 1.4 2.1 2.1 1.4 5.6 2.42.1 2.6 6.0 1.6 3.0 4.1 1.4 1.9 0.29 YGR157W 1.0 0.9 5.2 0.8 1.2 1.0 0.80.7 3.3 2.0 1.0 1.8 4.8 0.7 4.6 1.0 0.8 1.3 2.10 YHR043C 1.3 1.8 1.2 1.70.9 2.2 2.9 3.0 1.2 1.0 1.6 2.2 2.7 1.3 2.1 2.2 1.4 1.7 1.38 YHR044C 1.31.3 1.7 1.5 1.2 3.3 2.6 2.0 1.1 1.1 1.7 2.3 4.3 1.3 1.5 2.4 1.3 1.4 1.12YJR073C 1.1 2.4 2.7 2.7 0.6 2.2 2.9 1.0 6.8 2.8 2.8 4.1 10.0 2.3 28.93.7 2.9 2.6 0.99 YOR303W 1.1 2.2 0.5 1.0 1.2 1.8 1.2 1.6 0.9 5.2 0.9 1.93.3 1.6 4.1 1.2 1.2 0.8 1.47 YBR294W 6.3 12.0 0.9 2.6 1.4 1.2 1.1 1.05.2 5.2 1.2 1.0 3.1 1.3 1.0 0.9 1.0 0.9 0.18 YCL043C 0.6 3.7 2.5 0.7 0.91.3 1.0 0.8 1.6 1.2 1.7 1.5 4.1 0.6 5.7 0.8 0.9 1.0 2.37 YCL050C 1.0 1.11.9 0.7 1.4 1.2 1.2 1.2 3.0 2.9 1.3 1.2 2.8 1.2 0.8 0.7 1.0 1.0 2.20YCR012W 1.1 1.5 5.1 1.2 1.1 2.5 1.4 0.8 1.4 1.5 1.8 1.2 4.1 0.9 1.4 1.40.8 1.3 4.48 YDR158W 1.1 0.5 1.8 0.8 1.3 1.0 0.8 1.2 1.1 1.7 1.6 1.0 2.60.9 1.0 0.6 1.0 0.9 3.54 YDR204W 0.9 2.3 3.0 1.4 1.0 2.2 2.2 1.1 5.7 3.72.2 1.2 2.9 1.1 0.6 2.8 1.1 1.7 0.62 YDR313C 1.2 1.2 1.2 1.4 1.3 1.4 1.51.2 4.7 2.6 1.5 1.2 2.3 1.3 0.8 2.9 1.1 1.3 0.84 YDR368W 2.0 2.2 2.2 1.81.0 3.0 2.1 1.7 3.8 3.8 1.8 1.4 2.6 2.0 1.2 2.3 1.1 2.0 1.70 YER091C 3.63.9 30.7 1.3 0.9 2.3 2.1 0.9 5.8 1.4 3.2 2.0 5.4 1.2 10.2 2.7 1.2 1.01.23 YFR053C 1.7 1.4 3.0 2.2 0.9 3.2 2.1 2.8 0.6 1.1 1.5 1.7 3.0 0.6 0.63.0 1.4 2.2 4.17 YGL062W 0.6 1.3 1.1 0.6 0.9 1.0 1.3 0.8 1.6 2.5 0.7 1.64.5 1.2 2.7 1.5 1.1 0.9 0.77 YGL157W 0.7 0.9 1.8 0.9 1.5 5.4 3.3 1.4 0.61.8 1.4 1.5 4.8 1.2 5.1 1.7 1.8 2.3 1.69 YGL184C 4.6 15.9 57.4 1.3 1.11.0 1.2 1.9 37.9 66.8 1.7 2.6 7.4 1.4 0.4 1.5 1.0 0.9 0.16 YGR032W 1.01.4 1.0 1.3 0.7 1.9 0.8 0.6 0.5 0.7 1.5 1.5 3.9 1.1 5.4 1.5 3.2 2.8 1.18YGR124W 0.5 0.6 1.7 0.7 1.2 1.1 0.7 1.0 2.2 1.3 1.1 1.1 2.3 0.5 1.5 0.30.7 0.6 3.56 YGR192C 1.4 1.0 3.8 1.0 1.1 1.7 1.7 1.1 0.9 1.3 2.3 2.2 3.41.0 1.9 1.1 1.1 1.3 7.49 YGR244C 1.0 1.2 1.6 1.6 0.8 2.6 3.9 1.8 1.4 1.11.8 1.9 2.6 1.2 2.0 2.6 1.9 3.1 1.12 YGR254W 1.2 1.3 3.8 1.3 1.2 1.9 1.51.4 0.8 1.2 1.3 1.7 3.1 0.6 2.4 1.4 1.3 1.2 7.01 YHR018C 1.0 1.0 1.5 1.41.7 1.1 0.8 1.0 1.4 4.4 1.4 1.4 3.3 1.0 4.4 1.0 1.9 1.2 1.21 YIL160C 0.82.4 2.3 3.5 1.0 1.6 1.1 1.2 3.2 3.8 2.4 1.0 2.3 1.5 5.6 8.8 2.4 3.0 0.27YIR017C 3.5 8.6 2.5 1.9 0.8 1.9 1.5 1.2 5.2 3.4 4.2 1.2 3.4 1.9 2.3 3.01.5 1.3 0.36 YJL052W 1.5 0.9 4.0 1.8 0.7 2.4 2.1 1.5 1.6 2.0 4.3 2.4 5.61.3 2.3 2.3 1.2 1.9 6.19 YJR009C 1.1 1.7 5.6 1.0 1.2 1.6 1.6 1.1 1.1 1.31.1 1.5 2.7 1.0 2.1 1.5 1.1 1.3 5.86 YJR130C 1.1 0.6 0.8 0.9 1.4 2.0 1.31.3 5.2 3.8 1.7 1.0 2.9 1.1 0.9 1.5 1.1 1.3 0.62 YJR149W 1.0 1.8 1.4 2.30.8 1.0 1.7 1.0 1.4 1.0 0.7 1.0 3.5 1.4 1.4 2.4 1.1 1.2 0.34 YKL218C 2.11.0 2.2 1.8 1.2 3.6 1.6 1.7 3.4 2.7 1.7 1.2 5.1 1.4 0.8 3.1 2.5 2.6 0.60YLR027C 1.0 1.5 2.3 0.8 0.9 2.0 1.4 0.7 1.6 2.7 1.6 1.3 2.5 1.0 1.4 0.91.3 1.3 1.39 YLR133W 0.9 1.6 1.4 0.7 1.0 2.2 1.3 0.7 6.1 2.3 0.6 1.5 3.31.1 1.9 1.0 1.1 1.3 0.36 YLR155C 1.4 1.1 2.4 1.8 1.7 1.6 2.0 1.0 3.0 1.82.0 1.1 3.3 1.1 1.2 2.2 1.4 2.2 1.63 YLR158C 1.4 1.2 2.1 1.7 1.7 1.5 2.01.1 2.7 s 2.4 1.1 3.2 1.2 1.1 2.1 1.4 2.0 1.57 YLR195C 0.8 0.9 1.0 0.81.0 0.8 1.1 1.0 0.6 0.7 0.8 1.3 2.3 0.7 0.9 0.8 0.9 1.0 1.55 YLR345W 1.41.4 1.4 1.2 1.2 1.6 1.2 1.4 4.5 4.0 2.5 1.6 3.5 1.5 1.0 1.2 1.2 1.4 2.65YML004C 0.8 1.6 2.5 1.0 0.7 1.7 2.1 1.9 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0.27 YOR180C 0.8 1.1 1.0 1.0 1.0 0.7 0.8 0.9 0.3 0.4 0.60.8 0.9 1.0 1.1 2.4 0.9 2.3 0.55 YBR036C 0.8 1.7 1.8 1.2 1.2 1.3 1.3 0.71.0 1.0 1.5 1.0 1.9 0.8 1.5 1.6 2.1 1.8 2.05 YDR297W 1.5 0.8 0.8 1.1 0.91.4 0.6 1.5 0.3 0.7 1.4 1.0 0.8 0.9 1.4 1.4 1.9 1.9 1.73 YDR387C 0.8 0.91.2 2.2 0.9 1.2 1.3 0.7 1.4 2.0 2.0 0.9 1.3 0.9 1.4 2.7 1.2 1.1 0.86YOL096C 1.1 1.0 1.2 1.6 1.2 1.3 1.7 1.0 1.3 1.4 1.2 1.2 1.4 1.4 1.0 2.31.2 1.2 0.64 YPR184W 1.2 1.4 5.7 2.2 0.9 1.5 1.3 0.7 1.9 3.2 3.6 1.4 2.51.3 1.5 3.1 1.0 1.7 0.37 YBR298C 1.1 1.0 1.6 2.3 1.4 0.4 1.7 0.5 0.3 1.11.5 1.1 0.8 0.9 0.2 2.1 0.9 0.8 0.88 YDL078C 0.7 1.1 1.2 0.8 1.3 1.1 1.71.0 1.1 1.0 1.7 0.8 1.0 0.8 0.5 2.2 1.1 2.0 1.65 YDL215C 1.0 1.5 1.0 1.61.5 0.9 1.9 1.1 1.7 2.4 0.8 0.8 1.5 1.0 1.1 2.2 1.1 1.6 0.91 YGL035C 0.71.4 4.3 1.4 1.1 0.6 1.2 1.3 0.9 1.5 1.3 0.9 1.1 1.1 1.0 2.3 0.9 1.2 0.61YGR287C 1.3 1.0 1.3 1.5 0.8 0.8 2.2 1.3 2.6 4.2 1.5 1.1 1.7 1.1 2.3 3.01.0 1.1 0.38 YJL070C 1.3 0.9 1.1 1.2 1.3 2.0 1.4 1.1 1.0 1.1 1.3 1.0 1.81.3 3.5 2.2 1.1 1.2 0.34 YLR351C 1.0 1.4 1.3 1.5 1.3 1.4 1.4 1.2 0.8 1.21.1 0.9 0.9 1.4 1.2 2.0 1.3 1.8 1.75 YLR375W 0.9 1.5 0.9 0.9 1.0 1.3 0.91.0 1.6 1.2 1.6 0.9 1.6 0.9 1.3 2.2 1.0 1.0 1.05 YMR267W 0.8 1.8 0.7 0.91.0 1.4 1.2 1.5 0.4 0.8 1.0 0.8 0.7 1.0 0.9 2.6 0.9 1.3 0.94 YMR278W 0.71.7 1.4 1.0 1.2 1.3 1.8 1.1 1.4 1.7 1.1 1.0 2.5 0.8 1.8 2.5 1.0 1.5 0.62YMR293C 0.9 1.5 1.6 2.2 0.6 0.5 1.2 1.0 0.7 1.3 0.4 0.9 0.8 1.3 0.7 2.20.8 1.0 0.37 YNR072W 1.1 1.5 0.5 0.7 1.0 0.9 1.5 0.9 0.7 1.8 1.4 1.0 1.51.0 1.8 2.1 1.3 1.0 0.26 YOR363C 0.8 2.0 0.9 1.3 0.7 1.2 0.7 1.1 1.2 1.61.2 0.9 1.3 0.9 1.1 2.1 1.3 1.8 0.40

TABLE 8 Detoxification protein genes The level of expressed mRNA in thepresence of chemical substance/ The level of expressed mRNA in theabsence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7)(8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YDR453C1.1 2.7 4.4 3.0 0.7 1.7 1.0 1.3 4.5 6.1 2.3 0.9 1.4 3.8 2.3 5.6 1.0 1.51.53 YLL060C 12.5 4.2 2.3 2.6 0.9 1.4 2.0 5.8 13.0 23.2 14.1 1.1 1.810.6 1.5 3.6 1.9 2.3 0.57 YBL064C 2.6 2.8 3.9 1.7 0.8 5.2 2.5 2.4 4.53.8 2.9 1.7 4.1 5.0 1.3 5.0 1.2 2.3 1.67 YBR008C 3.0 2.4 4.9 0.7 0.9 1.00.9 2.8 54.6 21.1 9.4 0.8 2.0 4.1 0.8 3.1 2.0 1.2 0.37 YOR153W 1.6 0.95.1 1.1 1.0 7.4 2.6 0.5 3.2 1.2 1.0 4.0 11.8 0.3 3.6 1.6 2.5 3.1 1.91YHL047C 0.6 4.4 1.0 1.0 1.2 8.4 16.8 1.5 1.2 11.9 1.0 2.6 3.8 0.5 1.12.3 1.2 1.2 0.74 YCL035C 2.0 2.3 1.5 1.7 1.5 5.1 2.7 1.4 1.9 2.3 2.1 1.52.8 2.5 1.9 5.5 2.6 4.2 1.74 YGR197C 1.1 2.4 2.5 1.0 0.7 0.5 1.3 0.816.7 3.2 1.1 1.2 2.4 1.5 1.0 1.5 1.7 1.9 0.37 YHR055C 4.4 1.8 0.8 1.22.7 1.6 1.1 2.1 3.9 3.3 1.8 1.2 3.0 1.5 0.5 0.8 0.9 0.6 3.96 YNL239W 1.02.4 2.4 1.2 1.2 1.8 2.1 1.3 2.5 6.0 1.9 1.5 3.6 1.3 1.7 1.5 1.1 1.4 0.68YNL241C 1.3 2.5 4.3 1.0 0.8 0.9 3.2 0.9 3.4 7.4 3.0 2.0 4.9 1.1 7.0 2.81.0 1.0 0.68 YBR293W 1.9 3.1 1.0 1.8 0.8 0.9 0.9 0.9 5.5 2.4 1.1 1.0 3.01.4 3.1 1.6 1.0 0.9 0.94 YDL100C 1.0 1.2 1.1 0.8 1.0 2.1 1.6 1.7 5.4 3.22.8 1.5 2.5 1.4 1.0 1.3 1.2 1.4 2.60 YER185W 2.0 3.1 2.1 7.0 1.6 1.2 1.11.0 2.9 1.2 1.6 1.1 2.1 1.6 1.7 0.6 2.6 1.1 0.26 YGL013C 0.9 1.2 0.8 0.71.1 2.3 0.9 1.4 3.0 1.5 0.9 1.0 2.3 0.8 1.0 0.9 1.1 1.0 0.43 YHR053C 3.52.1 0.7 1.1 2.9 1.3 1.2 2.2 4.5 2.9 1.4 1.1 1.9 1.5 0.3 0.7 1.0 0.5 3.99YIR038C 1.3 3.5 4.6 2.0 0.7 2.5 2.0 1.3 4.6 4.5 3.4 1.1 2.5 2.5 1.2 6.02.8 2.0 1.11 YKL026C 2.7 2.0 1.2 4.9 1.0 1.8 2.5 1.8 7.5 3.0 3.0 1.0 2.31.8 0.8 6.6 1.6 3.3 0.61 YLL028W 0.6 0.9 4.6 0.5 0.9 1.7 1.0 0.7 1.2 2.30.7 1.3 4.1 0.7 3.1 0.6 1.2 1.2 1.02 YOR273C 0.7 1.0 1.7 1.0 1.1 0.4 0.40.6 0.6 0.5 1.5 0.8 2.6 0.5 0.8 0.6 3.2 3.1 1.20 YGR138C 1.1 1.6 1.0 1.20.8 0.8 0.7 1.0 0.5 1.0 0.7 0.6 0.6 0.9 4.5 0.7 0.7 0.7 1.24 YOR247W 1.70.6 3.6 1.4 0.6 0.2 0.5 0.7 0.1 0.4 2.9 0.6 0.3 0.4 7.3 0.2 1.2 0.9 2.23YPL163C 0.6 0.7 1.4 0.9 0.6 0.6 0.4 0.5 0.1 0.4 0.5 0.9 0.4 0.6 5.3 0.61.4 1.4 1.05 YHL040C 1.6 4.4 1.5 0.4 1.1 7.3 4.0 1.5 1.1 11.3 1.7 2.02.0 1.1 3.4 1.0 1.4 1.0 0.69 YEL065W 0.3 3.8 1.2 0.4 1.4 2.3 4.3 0.9 0.14.9 0.6 1.7 0.8 0.4 2.2 2.6 0.7 0.6 2.10 YIR002C 0.8 1.1 0.5 0.6 1.2 2.21.3 1.2 1.7 1.4 0.8 1.3 1.2 1.1 1.1 1.4 1.1 1.2 0.58 YNL259C 1.6 4.5 1.11.2 1.1 3.9 3.8 1.5 1.6 2.1 1.6 0.7 1.1 1.4 0.7 1.7 2.6 2.4 1.22 YBR145W1.5 0.7 2.8 0.9 1.1 11.5 58.8 1.0 0.1 1.1 1.1 1.0 2.0 2.2 1.2 3.6 1.72.0 2.17 YLR043C 1.4 1.4 2.0 1.8 2.0 1.4 2.6 1.1 2.8 2.5 1.4 0.8 2.0 2.10.5 1.8 1.5 2.2 2.12 YGR209C 1.6 3.1 3.5 1.5 1.9 1.9 1.7 1.6 2.4 6.3 3.10.9 1.4 5.0 1.3 1.9 1.3 2.4 3.17 YDL168W 2.3 2.0 2.1 0.9 1.2 1.4 1.1 1.78.2 4.7 1.9 0.6 1.3 1.6 1.2 1.1 0.9 0.8 1.08 YDR513W 2.2 2.5 2.3 2.6 0.92.1 1.6 1.6 4.6 3.1 2.0 0.9 1.8 2.0 1.3 3.8 1.3 3.2 3.10 YGR088W 1.3 1.27.7 2.4 1.0 1.3 0.8 0.8 1.5 3.2 3.9 1.1 1.2 1.3 0.7 5.6 0.9 2.0 0.75YHR048W 2.5 1.4 1.4 1.7 1.0 0.8 0.8 1.9 4.5 2.7 2.0 0.9 1.1 1.7 0.9 1.40.7 0.9 0.26 YJL101C 2.1 1.9 2.1 1.2 1.4 1.0 1.0 1.3 3.1 3.6 2.7 0.7 1.01.0 0.5 1.3 0.9 1.0 1.13 YML116W 4.1 1.3 1.5 1.4 1.2 0.9 1.4 2.2 1.4 3.14.3 0.5 0.8 2.0 1.9 1.0 1.0 1.0 0.94 YMR038C 1.9 1.7 1.8 0.8 1.5 1.0 1.11.9 2.4 2.6 2.7 0.9 1.7 1.1 0.6 1.5 1.2 1.3 1.76 YBR244W 0.6 1.4 2.0 0.91.7 1.0 0.6 1.0 1.4 3.0 1.5 0.5 0.4 3.7 0.4 0.7 1.2 1.2 3.42 YCL069W 0.915.7 0.9 0.8 0.9 1.4 1.3 1.2 6.9 1.0 0.9 0.8 1.3 1.4 0.9 1.0 1.0 0.25YKR105C 0.8 0.9 0.9 1.5 1.0 1.2 1.0 1.3 1.0 5.2 0.0 0.8 2.5 1.2 1.5 0.70.8 1.0 0.26 YOL158C 0.7 4.0 2.4 0.9 1.2 2.0 1.6 0.7 1.7 6.1 0.7 0.9 1.41.0 0.9 1.2 1.4 1.7 1.30 YDR256C 0.8 1.4 0.7 1.3 1.2 0.5 0.6 0.8 5.2 2.01.4 0.8 1.1 1.6 1.0 4.3 1.0 2.0 0.30 YGL254W 1.2 1.1 0.8 0.6 1.1 0.7 1.31.4 3.1 1.8 1.1 1.2 2.4 1.3 1.1 1.4 0.8 1.2 0.53 YKL064W 0.6 0.9 0.4 0.81.2 1.5 1.1 0.9 2.4 1.6 0.7 0.7 1.6 1.1 0.7 1.4 1.3 1.3 0.60 YLL057C 2.259.9 1.8 0.9 1.1 1.0 1.6 1.4 121.8 2.9 1.3 0.7 1.4 1.1 1.4 0.9 3.0 1.30.19 YPR200C 47.7 1.7 0.8 5.0 1.6 0.8 1.3 1.4 4.7 3.8 2.0 0.4 0.6 2.00.7 1.2 1.1 1.0 0.27 YJR104C 1.4 1.8 2.9 1.2 1.5 1.4 1.1 1.5 1.9 2.8 2.60.9 0.9 2.0 1.3 2.9 0.9 1.1 3.50 YKR106W 1.3 0.8 2.1 1.4 1.2 1.6 0.9 1.310.5 7.4 1.8 0.8 1.4 1.7 2.8 0.9 0.8 0.16 YOR031W 2.6 1.7 1.3 3.4 1.40.9 1.3 0.9 0.7 1.3 1.2 0.8 1.8 1.5 1.4 6.2 1.7 2.4 0.52 YHR008C 1.3 6.94.8 1.8 0.6 1.0 0.7 0.9 1.7 2.4 2.1 0.7 1.2 1.6 1.7 2.2 0.9 1.0 1.04YML028W 1.0 2.2 4.4 1.3 1.6 1.2 0.8 0.8 0.8 1.8 1.0 1.6 1.6 2.0 2.2 1.31.1 1.5 4.85 YEL027W 1.2 0.6 3.4 1.1 1.0 1.1 0.8 0.9 0.9 1.1 0.9 0.9 0.71.4 1.5 1.6 1.0 1.4 4.75 YKR066C 0.9 1.4 5.5 0.7 1.0 0.9 0.5 0.7 0.7 2.41.3 0.9 0.6 1.5 0.6 1.3 0.9 1.1 1.25 YDR538W 0.9 1.1 2.4 1.2 1.0 1.0 1.21.0 0.3 0.8 0.9 0.7 0.7 0.9 1.0 0.9 1.0 0.9 0.53 YMR015C 0.7 0.7 1.9 0.91.7 1.3 0.4 0.7 0.1 0.3 1.0 0.9 0.4 0.8 1.2 1.5 1.0 1.0 2.51 YOR251C 1.11.0 1.3 1.8 0.8 0.9 1.0 1.1 0.8 0.8 1.0 0.9 1.0 1.1 0.6 1.2 0.9 1.3 1.34YLR046C 0.7 1.7 0.9 0.8 1.0 3.8 1.5 0.5 1.0 1.4 0.9 0.8 1.2 1.3 0.8 1.35.2 5.4 0.86 YGR224W 0.9 1.2 1.2 1.2 1.4 0.8 0.4 0.6 0.9 0.9 0.8 0.6 0.80.9 1.1 1.0 2.8 1.3 0.27 YFL050C 0.7 1.0 1.1 2.2 1.0 0.9 0.8 0.9 0.5 1.61.2 0.9 1.2 1.0 1.4 2.3 0.8 1.0 0.36 YCR083W 1.1 2.8 1.5 1.8 1.6 2.4 1.81.5 1.8 1.8 1.8 1.1 1.8 2.4 1.0 3.1 1.3 1.3 0.98

TABLE 9 Genes belonging to other category The level of expressed mRNA inthe presence of chemical substance/ The level of expressed mRNA in theabsence of chemical substance yeast genes (1) (2) (3) (4) (5) (6) (7)(8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) Intensity YKR076W5.0 2.6 3.5 2.2 1.0 4.7 4.9 6.2 43.4 43.1 18.6 1.5 5.1 14.7 3.2 9.6 1.82.7 0.27 YNL335W 1.2 0.7 1.5 2.3 1.5 1.6 1.3 1.7 1.6 5.3 1.1 0.8 0.9 4.61.7 1.0 1.2 1.1 0.22 YBR173C 1.1 2.4 3.4 1.6 0.7 1.3 1.6 1.2 6.0 5.1 2.51.7 3.8 3.0 15.4 2.1 0.9 1.6 1.15 YFL022C 0.8 0.9 1.5 0.6 0.7 0.9 0.30.8 0.5 0.5 1.2 0.6 0.6 3.1 1.1 1.3 0.9 0.8 1.07 YGL158W 1.1 2.8 1.912.9 1.0 0.4 1.3 1.3 −0.4 0.9 0.2 1.3 1.0 2.3 2.3 8.2 0.8 1.1 0.18YHR139C 3.0 4.6 6.8 9.3 1.3 1.9 1.5 1.3 107.2 46.6 3.5 1.6 7.0 2.5 1.917.1 1.4 1.3 0.34 YGR213C 5.4 2.9 1.0 6.8 1.2 4.1 7.0 2.0 7.5 6.9 1.610.6 30.4 1.0 6.5 5.2 12.8 8.5 0.22 YKL165C 0.5 2.0 1.1 0.6 0.9 0.6 2.11.5 0.4 0.4 0.3 2.4 3.2 0.8 2.1 1.2 0.9 1.0 1.08 YBL005W-A 1.0 0.9 0.50.9 1.3 1.2 1.4 1.0 0.8 1.5 0.8 1.6 2.9 1.4 0.9 1.1 1.3 1.0 0.48 YBL041W1.2 1.4 0.9 1.0 1.6 1.7 1.6 1.7 2.8 2.6 1.6 1.6 2.6 2.0 1.3 2.3 1.3 2.03.03 YBL078C 2.3 2.7 1.3 2.6 0.7 2.4 3.1 1.6 12.3 15.2 4.6 3.1 5.0 3.62.5 4.4 1.8 2.8 0.65 YCL020W 1.1 2.5 0.5 1.1 0.5 1.0 1.5 1.7 0.9 2.4 1.31.5 3.0 1.7 2.5 1.3 0.9 1.3 1.46 YDL007W 0.8 1.4 1.3 0.9 1.0 1.1 1.2 1.43.8 2.4 1.3 1.1 2.4 1.4 1.4 0.8 0.8 1.5 2.43 YDL097C 0.9 1.7 0.9 1.2 0.81.3 1.6 1.5 4.5 2.3 1.5 1.3 4.0 1.4 1.1 1.1 1.0 1.3 2.06 YDL126C 0.5 1.42.3 0.7 0.9 1.2 1.5 0.8 2.7 2.0 1.4 1.3 4.3 0.6 1.7 0.7 0.9 0.9 3.24YER012W 1.4 1.2 1.2 1.0 1.9 2.4 2.4 1.8 6.7 2.7 1.9 1.5 2.9 4.6 1.7 2.21.5 1.3 1.84 YFR010W 1.1 1.1 0.8 1.2 0.9 1.3 1.4 1.6 4.3 3.4 1.5 1.2 3.71.1 1.5 1.3 0.9 1.4 1.89 YFR024C 0.8 25.0 2.3 1.1 0.7 1.4 3.0 0.9 5.34.1 1.9 1.5 2.8 1.2 0.9 1.9 1.0 1.4 1.06 YGL048C 1.0 1.3 0.7 1.3 1.8 1.52.0 1.5 2.4 2.1 1.5 1.3 2.5 1.2 1.0 1.6 1.4 2.0 3.07 YGL141W 0.8 1.2 1.10.7 1.4 3.0 1.7 0.8 4.5 1.9 0.6 1.4 3.6 1.2 1.5 1.2 1.4 1.2 0.44 YGL180W1.3 1.3 1.7 0.6 1.2 1.1 2.4 1.2 7.2 3.7 1.3 1.4 2.6 1.0 1.3 1.7 1.0 1.10.28 YGR048W 0.7 2.7 1.4 1.3 1.0 1.0 1.9 1.4 4.4 3.1 1.1 1.1 2.5 1.3 0.81.1 0.9 1.2 0.93 YGR135W 1.0 1.0 1.0 1.1 1.6 1.5 2.2 1.8 1.5 2.3 1.6 1.22.8 2.6 1.5 1.5 1.0 1.9 3.10 YGR201C 1.7 11.9 2.4 2.0 0.8 3.1 2.6 1.65.4 3.5 1.6 1.9 8.6 1.6 0.5 14.4 1.4 2.1 0.60 YHL030W 0.5 0.8 1.0 0.70.7 1.9 0.9 0.8 2.7 2.5 1.1 1.1 3.8 1.0 2.0 0.5 0.8 0.9 0.66 YHR166C 0.91.1 1.0 0.7 1.0 1.8 1.5 1.0 2.6 1.2 0.6 1.7 6.9 1.2 0.9 1.1 1.4 1.5 1.35YJR069C 0.8 0.8 0.9 0.6 0.9 1.2 1.3 0.9 0.7 0.6 0.9 1.1 3.9 0.6 0.4 0.81.0 0.9 1.73 YKL073W 0.6 1.4 0.5 0.6 1.2 0.5 2.1 1.6 1.3 1.1 0.5 1.5 3.30.7 1.6 1.0 1.2 1.5 1.29 YKL103C 1.6 4.1 2.5 2.1 0.9 2.7 2.8 1.6 8.3 9.92.8 1.3 3.8 2.0 2.1 1.2 1.9 2.2 0.56 YLR080W 1.0 1.4 1.2 1.7 1.1 2.5 2.81.3 2.3 1.5 1.9 0.8 3.6 1.2 0.7 3.0 1.6 2.2 0.41 YLR107W 1.2 0.9 0.5 1.21.7 2.3 1.6 1.1 1.8 1.2 0.8 1.0 2.9 1.6 1.1 1.6 1.8 2.4 0.94 YLR121C 1.71.7 1.1 1.2 1.0 1.6 1.3 2.2 2.0 2.2 1.1 4.0 1.2 10.7 1.5 2.7 1.4 0.30YLR336C 0.6 0.8 0.7 0.4 0.9 0.8 1.8 1.0 −0.3 0.5 0.5 1.9 4.6 0.6 0.8 1.31.5 1.0 0.71 YLR370C 1.1 1.0 1.1 1.4 1.4 4.1 2.1 0.8 1.5 1.9 1.0 1.2 3.11.9 1.5 1.6 1.6 2.0 1.41 YLR423C 1.2 1.2 0.7 1.9 1.5 1.2 3.8 2.0 1.2 1.01.0 1.7 3.9 1.2 1.3 1.9 1.2 1.6 0.34 YML092C 1.1 3.1 2.4 1.1 0.9 1.9 1.21.2 6.4 4.0 2.5 1.2 2.3 1.6 1.4 2.2 1.3 1.5 1.72 YML130C 1.5 2.7 5.3 1.20.9 0.6 2.9 2.7 7.8 4.2 1.9 2.3 5.8 1.3 2.4 0.8 1.2 1.2 1.59 YMR214W 0.83.8 1.0 1.4 0.8 0.9 1.0 1.1 2.1 1.0 0.7 1.0 2.4 1.1 4.8 0.7 1.1 1.0 0.88YMR297W 0.7 2.0 3.6 1.9 0.6 1.8 1.2 0.8 1.9 1.0 2.5 1.2 4.2 0.5 2.4 1.91.1 1.4 4.10 YNL036W 2.0 1.9 3.2 1.0 1.6 1.1 2.0 2.1 6.6 5.0 1.7 1.4 3.35.1 1.6 1.3 1.4 1.9 2.04 YOL005C 1.4 1.4 1.1 0.8 1.6 1.1 1.1 1.0 0.9 1.01.6 1.2 2.9 1.2 0.9 1.0 1.2 1.2 1.71 YOR134W 2.0 3.6 1.0 9.5 0.9 1.4 1.11.5 1.5 8.2 1.9 2.8 4.4 1.3 1.6 7.7 2.2 4.6 0.28 YOR362C 1.0 1.7 1.0 0.81.7 1.4 1.6 1.4 4.3 3.0 1.3 1.3 2.5 1.4 1.0 1.5 1.1 1.8 2.55 YAR009C 0.81.3 0.6 1.0 1.4 1.6 2.7 1.4 0.9 1.4 0.9 1.3 2.0 1.0 2.1 0.6 0.8 1.2 7.11YBL101C 1.0 1.1 1.9 0.9 1.0 0.9 0.8 0.8 3.0 1.4 0.8 1.1 3.5 0.9 2.7 1.41.0 1.1 0.39 YBR046C 1.4 1.4 1.7 1.8 1.3 2.6 3.9 1.6 4.6 6.2 2.9 1.2 2.01.3 2.1 3.0 1.2 2.0 0.63 YBR139W 1.2 1.4 3.1 1.4 0.8 2.4 1.9 0.7 2.3 1.62.3 1.2 2.7 1.1 5.6 2.3 1.2 2.0 1.21 YBR170C 0.8 1.2 0.6 1.4 1.5 1.4 1.91.3 6.1 4.2 1.5 1.2 2.7 1.3 1.9 1.3 1.1 1.4 0.72 YBR177C 0.8 1.1 4.0 1.21.2 2.3 0.9 0.9 2.1 1.7 0.6 1.2 3.1 1.3 1.4 0.4 0.8 0.9 0.76 YBR212W 0.71.2 2.6 1.2 1.0 1.4 0.9 0.6 2.7 2.3 1.1 0.9 2.2 0.7 1.0 1.5 1.1 1.0 0.95YBR239C 1.0 1.3 0.9 1.5 0.8 1.5 1.0 1.3 0.4 1.2 0.7 1.1 1.9 1.1 1.0 2.71.0 0.9 0.31 YCL033C 1.1 2.0 1.7 1.7 1.2 4.6 2.4 1.1 2.3 1.4 1.9 1.6 2.01.8 0.8 3.6 2.0 2.0 1.14 YCR062W 0.8 1.9 2.7 2.8 1.4 1.9 0.9 0.7 0.7 1.31.2 1.3 2.2 1.0 2.3 1.1 1.1 1.0 0.41 YCR067C 0.9 0.7 1.2 1.3 0.7 0.8 0.80.7 1.8 1.6 1.2 0.9 2.0 0.9 2.1 1.4 1.1 0.9 0.62 YDL020C 2.3 1.2 3.4 1.11.2 2.5 1.0 2.2 5.6 2.9 1.9 1.1 3.4 1.2 1.5 1.8 1.5 1.7 1.36 YDR168W 1.21.4 1.0 0.8 1.5 1.3 2.4 2.1 3.7 2.3 1.5 1.2 2.4 1.4 1.9 1.4 1.2 1.4 1.28YDR169C 1.0 1.4 1.1 1.3 1.3 1.2 1.1 1.0 1.6 1.4 0.9 0.9 1.9 0.9 1.4 0.91.4 1.1 0.40 YDR188W 0.8 1.2 1.0 0.8 0.8 0.8 0.9 1.0 2.9 1.6 0.9 0.9 1.70.7 1.3 0.9 0.7 0.8 1.78 YDR264C 0.5 2.6 0.9 1.4 0.9 1.8 3.2 0.8 1.1 3.40.9 1.1 2.1 0.7 2.3 1.5 1.2 1.4 1.63 YDR304C 1.0 1.8 2.7 1.3 1.5 2.1 2.01.3 3.9 1.9 1.2 1.3 2.3 1.7 1.0 4.0 1.6 1.8 2.23 YDR403W 1.0 1.2 1.6 1.01.2 1.1 1.2 1.2 4.1 3.6 1.0 1.0 2.0 1.1 0.9 0.9 0.9 1.0 0.35 YDR427W 0.81.1 0.8 0.8 1.5 1.9 1.4 1.2 2.3 2.0 1.2 1.1 2.1 1.0 1.3 1.1 1.0 1.5 2.37YEL012W 1.3 1.8 1.0 1.8 1.7 1.6 4.7 1.4 4.6 4.2 2.2 1.2 2.2 1.9 1.1 2.51.5 2.2 0.74 YER009W 1.3 0.6 2.4 1.2 1.2 2.0 2.8 1.0 0.7 1.0 1.4 1.1 2.01.6 0.9 1.5 2.0 2.1 3.35 YER021W 0.8 1.0 0.9 0.9 1.4 1.1 1.5 1.2 3.0 2.21.3 1.0 1.8 1.3 0.8 1.4 0.8 1.5 2.02 YER094C 1.0 1.3 0.9 1.1 1.9 1.1 1.81.3 2.3 1.7 1.3 1.1 2.1 1.5 0.8 1.5 1.3 1.8 3.01 YER177W 1.4 1.5 2.1 1.50.9 1.6 1.2 1.1 1.8 1.7 1.9 1.1 2.2 0.9 1.4 1.0 0.9 2.0 5.81 YFL029C 1.01.2 1.2 1.8 1.7 1.0 1.6 1.5 4.3 2.9 2.1 1.1 1.8 1.9 1.3 1.2 1.2 1.4 0.49YFL038C 1.0 1.2 0.7 1.3 1.5 1.3 1.7 1.4 2.1 1.9 1.7 1.1 2.1 1.5 1.5 2.11.2 1.6 2.31 YFR004W 1.0 1.5 0.8 1.4 1.0 1.5 1.3 1.4 3.6 2.6 1.3 1.2 2.02.1 1.1 1.3 1.0 1.4 2.44 YFR050C 0.9 1.2 1.1 1.3 1.7 1.5 1.4 1.4 3.1 2.11.4 1.5 2.1 1.6 1.5 1.5 1.1 1.7 1.70 YGL011C 1.2 1.5 1.1 1.1 1.8 1.6 1.51.3 2.0 2.2 1.5 1.0 2.1 3.0 1.3 1.7 1.3 1.5 1.78 YGL094C 0.8 1.3 0.3 0.91.3 1.0 0.8 1.0 1.4 1.1 0.6 0.8 2.3 0.9 1.9 1.0 1.0 0.9 0.51 YGL150C 0.70.8 1.2 1.0 0.8 1.1 0.8 0.8 1.4 0.9 0.4 0.8 2.4 1.0 1.3 0.9 0.9 0.8 0.62YGL207W 0.5 0.6 0.9 0.6 1.3 0.9 0.6 1.0 1.4 1.1 0.7 0.7 2.5 0.8 1.2 0.70.9 0.8 0.88 YGR232W 1.2 1.2 1.2 1.7 1.5 1.9 2.0 1.1 3.4 2.2 1.3 1.1 2.42.1 0.9 1.8 1.3 1.2 0.96 YGR248W 1.3 1.7 3.2 4.0 0.5 2.3 1.1 1.2 2.8 3.22.3 1.1 2.0 1.5 1.5 7.9 1.0 1.5 0.52 YGR253C 1.3 1.4 0.7 1.3 2.0 1.4 1.62.0 4.0 3.1 2.4 1.1 3.4 1.8 1.1 1.8 1.5 2.1 2.01 YHR027C 0.5 0.8 1.2 0.61.1 0.4 0.9 0.6 3.6 2.2 1.1 1.0 2.1 0.7 1.5 0.9 0.8 1.0 2.06 YHR161C 0.61.1 1.3 2.1 1.5 1.2 1.8 0.7 2.5 2.0 1.2 1.0 1.8 1.0 1.4 1.7 1.4 1.5 0.86YHR169W 0.6 0.5 0.4 0.4 1.1 1.2 0.9 0.9 0.0 0.2 0.4 1.1 3.3 1.1 0.6 1.01.6 1.3 0.81 YIL010W 1.0 1.2 1.4 0.8 1.2 4.4 1.5 0.9 1.4 2.2 1.4 1.4 2.31.7 1.1 1.7 1.5 1.5 0.70 YIL034C 1.0 0.8 1.5 3.0 0.7 1.7 1.2 0.9 2.1 1.31.6 1.0 2.6 1.1 1.0 1.7 1.2 1.5 0.99 YIL142W 0.7 1.1 0.9 1.1 0.8 1.1 0.81.1 4.4 3.0 1.7 1.1 1.8 1.0 1.3 0.7 0.9 0.8 1.84 YIR039C 1.4 1.8 4.3 4.21.5 3.2 4.1 1.1 4.4 4.1 3.8 1.4 2.9 1.9 2.0 4.2 1.2 1.1 0.45 YJL001W 0.91.7 1.2 2.0 1.7 1.6 1.3 3.1 2.8 1.5 1.6 2.9 2.5 1.2 1.8 1.0 1.6 3.00YJL035C 0.9 1.3 0.8 0.6 1.4 0.7 1.3 1.5 1.7 1.4 0.8 1.1 2.4 1.6 0.7 0.61.0 1.0 0.82 YJL053W 1.1 0.9 1.7 1.3 1.1 2.0 1.7 1.3 2.2 2.2 1.6 1.1 1.91.3 1.1 1.7 1.3 1.6 0.80 YJL164C 1.1 1.1 1.0 1.9 1.1 2.7 3.1 0.9 2.1 0.81.5 1.0 2.1 0.9 0.8 2.1 1.3 1.7 1.04 YJL210W 1.2 1.4 1.6 2.0 0.6 0.6 1.01.0 2.0 0.9 2.4 1.0 2.2 0.9 0.8 2.3 0.9 1.0 0.70 YJR117W 1.0 2.1 2.3 0.71.2 1.3 1.0 0.8 4.7 2.3 1.0 1.2 2.8 0.8 2.2 0.7 0.8 0.9 1.34 YKL007W 1.21.6 1.2 0.9 1.0 0.9 1.5 1.2 2.3 2.4 1.8 1.3 2.5 0.7 1.0 1.0 1.4 1.3 1.13YKL117W 1.0 1.3 0.8 1.0 1.8 1.0 1.3 1.5 2.9 2.1 1.6 1.0 2.4 1.6 1.6 1.81.2 1.8 3.73 YKL193C 1.3 0.8 1.1 1.4 1.1 0.9 2.1 1.4 1.0 1.6 1.7 0.9 2.11.2 1.2 2.4 1.2 2.3 0.71 YLR120C 1.2 1.9 2.4 1.6 1.1 1.9 1.5 0.9 1.8 1.61.2 1.6 4.8 0.8 2.7 1.7 3.5 2.9 1.53 YLR136C 1.3 9.0 0.6 3.3 1.6 1.7 3.91.1 0.9 6.0 1.2 1.3 2.9 0.7 2.1 1.2 1.8 1.4 0.41 YLR178C 1.7 6.9 8.8 4.61.0 4.2 3.3 0.9 4.3 4.1 3.7 2.2 7.5 2.8 2.3 10.6 2.0 3.6 1.03 YLR327C5.5 3.3 14.4 8.2 1.3 5.1 5.7 2.2 3.0 8.3 5.0 1.4 2.8 1.5 0.8 2.8 3.3 5.32.23 YLR356W 1.0 2.9 4.9 1.2 1.1 3.4 1.1 0.7 2.3 1.6 3.1 1.5 2.5 2.2 2.80.9 1.1 1.0 0.41 YLR362W 1.1 1.2 1.0 3.0 1.5 0.8 1.9 1.4 3.5 3.3 1.5 0.82.4 1.2 1.3 1.9 1.2 1.3 0.35 YLR429W 0.7 1.0 0.6 0.9 1.4 0.8 1.3 1.0 0.91.3 0.9 1.1 2.3 0.7 1.5 1.0 1.0 0.9 0.86 YMR004W 0.9 0.9 1.3 1.3 1.0 0.51.2 1.0 94.2 3.4 2.5 1.0 2.2 2.2 1.3 1.3 0.9 1.3 0.52 YMR219W 0.7 1.11.0 0.7 1.6 0.8 1.1 2.3 0.9 1.5 1.5 2.1 0.5 1.7 0.8 1.1 0.9 0.23 YMR275C0.7 0.7 1.2 0.6 0.7 1.4 0.8 0.8 2.4 2.1 1.1 0.7 2.1 0.8 1.7 1.0 0.9 0.70.79 YMR314W 1.2 0.9 1.3 1.3 1.1 1.2 5.9 2.7 1.8 1.0 2.6 1.0 1.2 1.6 1.31.6 1.67 YNL006W 1.1 2.1 1.3 1.5 0.9 1.0 1.6 1.1 4.0 4.0 1.1 0.7 2.3 0.80.7 0.9 1.0 1.3 1.20 YNL007C 0.7 2.4 5.1 0.8 1.2 0.6 1.2 0.8 3.0 1.7 1.30.7 2.1 0.4 0.8 0.5 1.1 1.0 3.62 YNL093W 2.1 6.4 0.4 4.5 1.2 1.6 1.4 0.81.7 2.0 1.6 1.1 2.2 1.1 0.6 4.9 3.0 3.1 0.32 YNL333W 1.0 1.4 1.7 2.3 1.51.5 2.9 2.1 2.3 2.1 2.0 1.0 2.2 1.9 1.0 1.4 1.4 1.1 0.49 YNR010W 1.3 1.20.5 2.8 1.8 1.3 1.5 1.1 1.7 0.9 1.4 0.8 2.8 1.3 0.8 1.2 1.7 2.3 0.37YNR069C 1.5 1.3 0.7 0.4 1.4 1.7 1.4 1.4 5.5 5.8 2.5 1.2 3.4 2.1 1.0 0.81.1 0.9 0.18 YOL164W 0.9 4.4 1.0 1.5 1.6 1.2 2.2 1.0 4.9 3.6 1.0 1.1 3.41.3 1.0 1.1 1.1 1.3 0.45 YOR036W 1.8 0.9 1.4 1.6 1.1 1.7 1.8 1.4 1.2 1.91.3 1.2 2.1 1.2 1.2 1.3 1.6 1.7 0.98 YOR117W 0.8 1.3 1.7 0.8 1.2 1.1 3.31.0 3.5 1.8 1.2 2.5 2.3 1.0 1.4 1.2 1.4 0.9 1.42 YOR124C 0.6 1.1 1.3 0.81.1 0.9 1.1 1.3 2.0 1.9 1.2 0.9 2.1 0.8 1.3 0.9 1.0 1.0 0.65 YOR132W 0.91.6 0.8 2.8 1.1 1.6 1.4 1.2 2.8 1.6 1.3 0.7 2.5 0.7 1.5 1.6 1.2 1.6 0.46YOR157C 1.0 1.3 1.2 1.3 0.7 1.2 1.2 1.2 5.7 2.6 1.6 1.3 2.4 2.2 1.9 0.91.2 1.2 1.23 YOR185C 1.1 1.3 1.9 1.1 1.2 3.0 1.3 1.4 1.9 2.9 1.2 1.5 2.22.1 1.0 2.2 0.9 1.1 1.67 YOR259C 0.8 1.1 0.8 0.9 2.0 0.8 1.3 1.1 2.7 1.51.0 0.8 1.8 1.2 1.3 1.4 0.9 1.5 2.33 YOR261C 1.0 1.4 0.6 0.9 1.5 1.4 1.92.6 5.5 2.5 2.1 0.9 2.5 1.8 1.3 2.0 1.0 1.9 2.80 YOR288C 0.9 1.3 1.1 1.11.1 1.0 2.0 1.9 0.9 1.0 1.4 1.4 2.4 0.8 1.8 1.4 1.5 1.6 0.79 YPL109C 1.12.5 0.5 1.2 1.2 1.2 1.8 1.1 1.2 1.5 −0.2 0.9 1.8 1.3 1.3 1.9 1.2 1.20.21 YPL149W 1.5 1.5 0.6 2.8 0.8 0.9 1.2 1.1 5.6 3.7 1.2 0.9 2.3 1.0 0.81.2 2.2 2.9 1.39 YPL154C 0.7 3.3 4.2 1.2 1.2 3.5 1.5 0.8 2.8 1.7 1.8 1.53.1 0.8 4.0 1.8 1.6 2.0 3.78 YPR103W 0.7 1.1 1.3 0.7 1.7 1.2 1.6 1.0 5.52.0 0.9 1.2 2.8 1.8 1.0 1.1 1.2 1.5 1.93 YPR108W 0.8 1.0 1.3 0.6 1.3 1.51.6 1.6 3.7 2.8 1.8 1.0 2.6 1.0 1.3 1.2 1.0 1.3 2.25 YCL027W 0.7 2.0 1.01.0 1.2 1.3 1.0 0.6 0.7 16.3 0.9 0.8 1.1 1.2 3.6 1.1 0.7 0.8 0.30YDR055W 1.7 2.1 2.2 2.8 1.7 3.9 1.5 1.6 0.8 2.4 2.2 1.4 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1.3 1.38 YPL218W 1.5 0.9 2.51.7 1.1 1.5 1.3 1.4 1.1 1.2 1.1 1.2 1.0 1.5 1.1 1.7 1.1 1.8 2.98 YPL220W1.3 0.9 2.3 1.4 1.1 1.3 0.6 1.2 0.0 0.5 1.3 0.5 0.1 0.6 0.6 0.5 1.1 1.18.33 YPR080W 1.3 1.3 2.8 1.2 1.4 1.4 0.9 1.3 0.7 1.1 1.0 1.0 1.3 0.6 1.50.6 1.1 1.0 8.03 YPR181C 0.5 0.8 2.3 0.6 1.0 2.0 1.3 0.5 1.0 0.7 1.3 1.01.7 2.4 1.5 1.6 1.8 1.6 1.84 YBR290W 1.3 1.4 0.8 3.0 1.0 1.1 1.4 1.5 2.01.8 1.2 1.0 1.7 1.4 0.9 1.3 1.2 2.1 1.34 YCR091W 1.3 1.1 0.6 2.2 1.3 1.31.3 1.1 0.8 1.2 0.8 1.1 1.3 1.3 0.7 2.7 1.3 1.4 0.22 YFL026W 1.0 0.8 1.25.0 1.4 1.0 1.2 1.3 0.6 1.5 1.3 0.8 1.1 1.1 1.0 1.0 1.0 1.0 0.27 YOR003W0.9 1.1 1.3 3.3 1.6 1.1 1.1 0.9 1.6 1.3 0.7 0.8 1.0 1.2 2.8 1.3 1.0 1.10.30 YCR038C 0.9 1.1 0.9 2.5 0.9 0.9 0.9 0.9 0.7 0.7 1.1 0.8 1.0 1.1 0.71.0 0.9 1.1 0.31 YDL119C 1.0 0.8 0.6 2.2 0.9 0.6 1.3 1.1 1.3 1.1 1.5 0.91.1 1.2 0.5 1.2 1.0 1.0 0.77 YDL220C 0.9 1.3 1.1 1.6 1.2 1.8 1.1 0.8 0.21.3 0.8 1.0 1.6 0.9 1.6 0.8 1.1 0.9 0.24 YDR125C 1.1 0.9 1.0 1.7 1.1 0.81.0 1.2 0.7 1.9 1.0 0.8 0.9 1.0 0.8 1.7 0.9 1.2 0.35 YDR225W 1.0 0.6 0.61.6 1.9 0.5 0.4 0.8 0.3 0.7 2.7 0.4 0.2 0.8 0.1 0.8 1.1 1.8 5.54 YER066W0.9 0.7 0.9 2.1 1.5 1.3 1.3 0.7 1.7 1.4 1.5 0.7 0.9 1.1 0.5 3.3 1.1 1.10.66 YER076C 0.8 0.9 1.2 1.9 1.1 0.6 0.8 0.7 0.2 1.2 0.7 0.7 1.1 0.9 0.81.3 1.0 1.0 0.33 YFR006W 0.9 1.8 1.1 3.4 0.7 0.8 1.4 1.0 −1.6 0.7 1.21.0 0.9 0.9 0.8 1.2 0.9 1.3 1.54 YGL208W 0.9 1.8 1.1 2.2 0.7 0.6 1.1 0.71.4 1.3 1.3 0.8 1.5 0.9 1.8 3.1 0.8 1.3 0.32 YGR023W 1.0 0.9 1.1 4.2 1.01.2 1.0 1.2 1.2 3.2 2.4 0.9 1.4 1.3 1.1 0.9 1.2 1.5 0.69 YGR108W 0.9 3.90.3 3.6 0.8 0.1 0.3 0.5 0.0 0.1 0.5 0.4 0.3 0.8 0.2 0.4 0.7 1.0 0.93YHR195W 1.1 1.5 0.6 2.4 1.5 1.0 1.3 1.6 1.8 0.8 1.4 0.9 1.2 1.2 0.7 3.71.0 1.5 1.12 YIL050W 1.0 1.3 1.3 2.4 0.9 0.7 1.1 1.2 1.3 1.9 0.9 1.0 1.01.3 0.6 2.7 1.0 1.1 0.52 YJR050W 1.0 0.6 0.7 2.1 1.2 1.4 1.1 1.8 2.0 1.30.8 0.8 1.9 1.3 0.9 1.5 0.9 1.1 0.85 YKL093W 1.0 1.6 1.4 3.6 0.8 0.8 0.70.9 1.5 1.6 0.9 0.9 1.2 1.1 0.8 2.9 0.8 1.0 0.38 YMR053C 1.1 1.0 0.8 2.10.9 1.3 0.9 1.0 2.2 1.4 1.3 0.9 1.5 1.3 2.4 2.3 1.1 1.6 0.31 YNL139C 0.81.1 0.8 2.0 1.9 1.0 1.0 0.9 0.6 0.7 0.8 0.5 1.2 0.7 1.4 1.1 1.1 1.0 0.47YOR122C 1.0 0.7 1.8 1.9 1.7 1.3 1.2 1.0 1.1 0.9 1.5 0.8 1.0 1.2 1.6 1.51.0 2.2 3.06 YOR312C 1.2 0.4 1.0 1.9 0.7 0.6 0.6 1.2 0.0 0.3 0.8 0.7 0.10.7 0.7 0.5 1.2 1.0 5.24 YOR327C 2.3 1.8 0.5 1.9 1.0 1.4 1.4 1.9 1.4 2.22.1 1.0 2.1 1.5 0.9 1.5 2.2 2.1 1.46 YPL001W 0.9 0.9 1.0 2.5 1.7 0.7 1.01.2 0.7 1.0 1.3 0.7 0.8 1.3 1.3 0.8 0.9 1.2 0.74 YPL230W 1.2 1.7 1.8 4.00.8 1.0 1.1 1.0 0.9 2.7 3.1 1.0 2.0 1.3 0.7 2.0 1.0 1.6 0.47 YER025W 0.60.7 0.6 0.6 1.5 1.0 1.5 1.1 0.4 0.6 1.2 0.7 0.6 2.1 0.8 2.6 1.8 2.3 1.96YHR185C 0.9 1.1 1.4 0.7 1.4 1.0 1.3 0.8 −0.6 0.9 0.7 0.8 0.4 1.7 1.3 3.21.4 3.0 1.64 YIL076W 1.3 0.6 1.1 1.0 1.8 0.6 0.5 1.3 1.0 1.4 1.1 0.8 0.81.4 1.0 0.8 1.2 2.5 3.73 YMR238W 1.9 1.3 1.1 1.3 1.5 1.3 1.2 0.9 1.3 1.41.2 1.0 1.5 1.2 2.3 1.4 2.2 2.4 1.36 YBR009C 1.6 0.8 0.4 1.7 1.4 1.0 0.51.2 0.6 0.6 0.8 0.5 0.4 1.1 0.2 0.4 1.0 2.4 7.00 YBR010W 1.0 0.8 0.5 2.00.8 1.1 0.8 1.3 0.5 0.7 1.0 0.7 0.4 1.0 0.3 0.8 1.1 2.3 7.25 YCL067C 1.21.1 0.3 1.7 1.1 1.7 1.3 1.7 1.4 1.9 1.6 1.0 1.4 2.1 2.2 1.7 0.8 2.2 3.15YCR096C 1.1 0.9 0.4 1.6 2.1 1.2 1.7 1.5 1.2 1.6 1.4 1.0 1.0 2.1 2.1 1.81.0 2.1 2.34 YDL137W 1.4 1.1 1.2 1.2 1.8 1.0 2.0 1.1 1.1 1.3 1.5 1.6 1.71.4 1.3 2.3 1.3 2.2 4.95 YDL192W 1.4 1.0 0.6 1.2 1.4 1.0 1.7 1.5 0.8 0.61.3 1.1 0.9 1.2 1.3 1.3 1.1 2.3 5.57 YDR224C 1.1 0.7 0.8 0.9 1.2 1.0 0.81.4 1.1 1.3 1.1 0.7 0.5 1.7 0.3 1.1 1.2 2.2 5.62 YDR378C 1.3 1.3 1.4 1.31.0 1.0 1.4 1.5 0.5 1.3 0.8 0.9 0.8 1.4 0.8 1.0 1.7 2.2 2.40 YMR197C 1.31.6 1.4 1.9 1.1 1.6 1.5 1.4 1.9 2.5 1.0 1.1 1.5 4.1 1.7 1.9 1.2 2.2 1.20YOL109W 2.0 2.0 1.5 1.8 1.0 1.3 1.2 1.5 0.1 1.1 1.0 0.8 0.5 1.4 1.0 0.81.6 2.2 4.13 YPL010W 1.0 1.1 0.9 1.0 1.4 1.0 1.9 1.5 1.7 1.5 1.3 1.1 1.11.3 1.2 1.3 1.3 2.0 3.25 YHR132C 0.8 0.7 1.7 1.4 1.0 0.7 0.8 0.8 0.9 1.11.1 0.8 1.2 0.9 1.4 2.3 0.8 1.3 1.52 YJL141C 1.0 0.8 1.0 1.6 1.5 1.1 1.10.9 1.2 1.3 1.2 0.8 1.4 0.8 0.8 2.2 1.4 1.6 0.94 YKR098C 1.0 1.1 1.2 1.71.1 1.8 1.7 1.3 1.4 2.7 1.9 1.1 1.4 1.4 0.9 3.9 1.1 1.6 0.55 YLR206W 0.71.6 1.4 1.1 1.1 0.5 0.7 0.8 1.5 1.0 1.3 0.8 1.4 0.8 2.4 2.3 1.1 1.2 0.72YAL055W 1.2 1.0 0.9 1.0 1.4 1.3 1.5 1.9 1.0 1.4 1.3 1.2 1.5 1.6 1.1 2.61.3 1.3 0.62 YAR062W 1.2 1.8 1.4 0.7 1.0 0.6 1.3 0.9 0.4 0.9 −1.1 0.81.2 1.1 1.3 2.4 0.9 1.0 0.32 YBL102W 0.8 1.0 1.4 1.2 0.9 2.5 1.6 0.8 2.31.1 1.2 0.9 1.7 1.1 1.1 2.0 2.4 1.5 1.26 YBR161W 1.2 0.8 2.3 0.7 1.1 3.00.9 0.4 0.4 1.1 0.6 1.0 0.9 1.5 2.1 1.5 2.2 0.72 YCR039C 1.9 2.1 0.3 0.91.9 1.5 1.4 1.6 1.8 2.2 1.2 0.8 1.0 1.7 1.9 2.1 1.0 2.1 1.73 YDL018C 1.30.9 0.9 1.1 1.8 1.4 1.2 1.3 1.0 1.0 0.9 0.7 1.0 1.5 1.1 3.1 1.5 1.7 0.84YDR022C 1.1 1.2 0.8 0.9 1.5 2.2 1.8 1.4 0.9 1.4 0.9 0.7 1.3 2.1 1.0 2.11.3 1.2 0.47 YDR181C 1.1 1.2 0.8 1.4 0.9 0.7 1.0 1.2 2.0 0.9 0.8 0.7 0.71.3 1.2 2.0 0.8 1.2 0.48 YGR036C 0.9 0.8 0.9 1.1 1.3 1.3 1.0 0.8 0.9 0.90.9 1.0 1.3 1.0 0.7 2.0 1.3 1.1 1.12 YGR120C 1.2 1.8 0.5 1.0 1.8 1.5 1.61.3 0.3 1.2 1.1 0.7 0.5 1.0 1.2 1.9 1.1 1.2 0.36 YGR131W 0.8 2.1 1.9 1.10.9 1.9 1.1 1.1 1.9 5.8 1.1 0.5 1.4 2.0 0.8 2.6 1.3 1.0 0.41 YGR167W 1.11.1 0.6 1.5 0.9 1.7 1.4 1.4 1.4 1.9 1.1 1.1 1.6 1.7 1.6 2.8 1.3 1.7 1.79YHL024W 1.2 0.8 1.6 1.1 1.5 1.2 1.3 0.8 2.1 3.6 1.1 1.6 1.6 2.1 2.9 3.81.4 1.4 0.58 YJL113W 1.2 1.9 1.2 1.2 0.7 1.2 1.3 1.3 2.1 1.2 0.7 0.9 1.31.7 2.1 0.9 1.5 0.41 YJL146W 1.3 1.9 1.2 2.0 0.8 0.7 1.3 1.0 1.0 1.7−1.1 1.1 0.8 1.5 1.2 1.8 1.0 1.3 0.30 YJR019C 0.8 1.8 1.9 1.6 1.1 0.80.9 0.7 1.1 0.6 2.4 1.1 1.4 0.8 1.1 2.6 1.8 1.4 0.33 YJR049C 1.0 1.2 1.01.0 0.7 0.6 1.0 1.2 1.4 1.4 1.6 1.0 2.1 1.2 1.2 1.7 0.9 1.2 0.44 YLR078C0.9 1.1 0.7 1.4 0.8 1.2 1.1 0.8 1.1 2.9 1.0 0.8 1.2 0.6 2.2 1.2 1.2 1.02YNR037C 0.9 0.9 0.9 1.7 1.2 0.7 1.7 1.1 1.3 1.7 1.5 0.7 2.0 1.2 0.8 1.91.4 1.6 1.34 YOR028C 1.4 0.7 1.1 2.3 1.6 1.0 1.2 1.5 1.2 2.0 1.5 0.6 0.81.3 1.1 3.7 0.8 1.7 0.78

The tables show that the expressed mRNA of about 700 of 2400 unknownyeast genes was induced by any one of toxic chemical substances such asheavy metals, agricultural chemicals, surfactants (Table 1), as well asthe expressed mRNA of 167 mitochondria-located genes (Table 2), 52 DNArepair genes (Table 3), 161 energy genes (Table 4), 142 transportfacilitation genes (Table 5), 90 stress protein genes (Table 6), 142metabolism genes (Table 7), 60 detoxification genes (Table 8), and 507genes belonging to other category (Table 9). Here, when the value of thefollowing is 2 or more, then it is considered significant:

$\;{\frac{{The}{\mspace{11mu}\;}{level}\mspace{14mu}{of}\mspace{14mu}{expressed}\mspace{14mu}{mRNA}\mspace{14mu}{in}\mspace{14mu}{the}\mspace{14mu}{presence}{\;\;}{of}\mspace{14mu}{chemical}\mspace{14mu}{substance}}{{The}{\mspace{11mu}\;}{level}{\mspace{11mu}\;}{of}\mspace{14mu}{expressed}\mspace{14mu}{mRNA}\mspace{14mu}{in}\mspace{14mu}{the}\mspace{14mu}{presence}{\mspace{11mu}\;}{of}\mspace{14mu}{chemical}\mspace{14mu}{substance}}.}$

“Intensity” indicated in the rightmost column of Tables 1 to 9 is avalue of the level of expressed mRNA of each gene in control cells asdivided by the average level of the expressions of the whole genes. Whenthe intensity is low, the error of measurement may be possibly large.The detection is considered more precise when expression magnification(expressed mRNA in the presence of chemical substance/expressed mRNA inthe absence of chemical substance) is larger. Yeast gene as used in theprocesses according to the invention is selected, of which the intensityis preferably 0.3 or more, more preferably 0.5 or more, and of which theexpression magnification is preferably 3 or more, more preferably 5 ormore.

1. A process for detecting 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrilein a test material, which comprises contacting the test sample with acell comprising one or more yeast genes selected from the groupconsisting of YCR107W, YFL056C, YLL057C, YHR139C, YMR004W, YPR167C,YDL218W, YDL243C, YBL075C, YLL056C, YNL277W, YBR008C, YPL280W, YOL165C,YJR155W, YGR142W, YJR010W, YBR241C, YKL107W, YGR154C, YFL030W, YFR030W,YFL055W, YMR322C, YBL065W, YER103W, YBR256C, YGR197C, YLL062C, YDR253C,YJL163C, YLR216C, YNL117W, YLR092W, YBR213W, YPL196W, YHR112C, andYDR374C, and detecting an increase in mRNA, wherein at least a five-foldincrease in mRNA of one or more of the genes indicates the presence of2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile in the test material. 2.The process according to claim 1, which comprises: (1) adding a testmaterial to the cell, and incubating them; (2) extracting mRNA from thecell; (3) preparing cDNA from the mRNA via reverse transcription usinglabeled nucleotides; and (4) hybridizing the cDNA with polynucleotideshaving the nucleotide base sequences of the one or more genes as definedin claim
 1. 3. The process according to claim 1, wherein the mRNA isdetected by northern blotting.
 4. The process according to claim 3,which comprises: (1) adding a test material to the cell, and incubatingthe mixture; (2) extracting mRNA from the cell; and (3) hybridizing themRNA with polynucleotides having the nucleotide base sequences of theone or more of the genes.
 5. The process according to claim 4, whereinthe step (3) is conducted on a microarray containing a combination ofthe genes.
 6. The process according to claim 1, wherein an increase inmRNA of all of the genes in the plurality of yeast genes indicates thepresence of 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile in a testmaterial.
 7. The process according to claim 1 wherein said cell is aprokaryotic cell.
 8. A process for detecting2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile in a test material, whichcomprises contacting the test sample with a cell comprising one or moreyeast genes selected from the group consisting of YCR107W, YFL056C,YLL057C, YHR139C, YMR004W, YPR167C, YDL218W, YDL243C, YBL075C, YLL056C,YNL277W, YBR008C, YPL280W, YOL165C, YJR155W, YGR142W, YJR010W, YBR241C,YKL107W, YGR154C, YFL030W, YFR030W, YFL055W, YMR322C, YBL065W, YER103W,YBR256C, YGR197C, YLL062C, YDR253C, YJL163C, YLR216C, YNL117W, YLR092W,YBR213W, YPL196W, YHR112C, and YDR374C, and detecting an increase inmRNA, wherein an increase in mRNA of all of the genes indicates thepresence of 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile in a testmaterial, and the level of increase in mRNA is at least ten-foldcompared to the level of mRNA in the absence of2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile.
 9. The process accordingto claim 8, wherein the level of increase in mRNA in the presence of2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile is at least thirty-foldcompared to the level of mRNA in the absence of2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile.
 10. The process accordingto claim 1, wherein the level of increase in mRNA in one or more of thegenes in the presence of 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrileis at least ten-fold compared to the level of mRNA in the absence of2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile.
 11. The process accordingto claim 1, wherein the level of increase in mRNA in one or more of thegenes in the presence of 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrileis at least thirty-fold compared to the level of mRNA in the absence of2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile.